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Can a simple blood test spot hidden heart trouble during High-Pressure oxygen treatment?

NCT ID NCT07492030

Diagnosis Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central venous and arterial blood) can accurately diagnose low cardiac output in patients with septic shock from severe skin infections. About 74 adults will be monitored during hyperbaric oxygen therapy. The goal is to see if this test works under high-pressure conditions, helping doctors detect heart problems faster.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients diagnosed with necrotizing dermo-hypodermitis who are receiving OHB treatment for the first time at the Regional Hyperbaric Oxygen Therapy Center at Lille University Hospital, a tertiary referral center where complementary hyperbaric oxygen therapy treatment for necrotizing dermo-hypodermitis in the Hauts-de-France region is centralized.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of necrotizing fasciitis complicated by septic shock as defined by the Surviving Sepsis Campaign * Indication for HBOT according to the criteria of the 2016 European Consensus Conference * Patient intubated and ventilated prior to the HBOT session, receiving intravenous sedation at doses sufficient to be in a passive ventilation state * Patient equipped with a central venous line in the superior vena cava allowing central venous blood gas analysis * Patient with an arterial catheter allowing arterial blood gas analysis Exclusion Criteria: * \- Minors * Pregnant women * Persons deprived of their liberty (prisoners, persons under guardianship or trusteeship) * Persons not affiliated with or not covered by a social security system * Patients on spontaneous ventilation * Patients without an echocardiographic assessment window (anechoic) * Severe ARDS according to the Berlin classification * Technical impossibility of sampling central arterial or venous blood * Absolute contraindication to hyperbaric oxygen therapy (undrained pneumothorax, unstable angina or acute myocardial infarction, severe asthma attack) * Relative contraindication to hyperbaric oxygen therapy * Respiratory: Chronic respiratory failure, severe pulmonary emphysema * Circulatory: Rhythm or conduction disorders * Neurological: uncontrolled epilepsy * ENT: sinusitis, otitis, chronic rhinitis; laryngocele; acute otitis media; osteospongiosis * Ophthalmic: retinal detachment

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Conditions

The condition(s) this trial relates to.

cellulitis necrotizing fasciitis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cellulitis Necrotizing fascitis Septic shock

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Centre d'Oxygénothérapie Hyperbare du CHU de Lille

    Lille, 59037, France

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