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Can a cream with good bacteria fix sensitive skin?

NCT ID NCT07454525

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether a facial cream containing postbiotics (beneficial bacteria byproducts) can improve the skin microbiome and appearance in 45 women aged 40-60 with sensitive skin. Participants will use a placebo cream for 6 weeks, then the active cream for 8 weeks. Researchers will track changes in skin bacteria and take photos to see if skin looks healthier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Facial cream with postbiotics from Bifidobacterium and Pediococcus
What this could lead to
If it works, this could point toward a skincare product that improves skin health and appearance by supporting the skin microbiome.
What could go wrong
This is a small, early-stage study with only 45 participants and no blinding. It measures microbiome changes, not clinical outcomes, so results may not translate to real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 60 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 40-60 among all ethnicities and Fitzpatrick scale. * With self-assessed sensitive skin (SS10 \> 13) and self-reported mild to moderate fine lines and wrinkles. * Must spend minimum 1 hour outside from 10am-4pm at least 5 times per week. * Residing within the same country on the mid to west coast (California, Nevada, Utah, Arizona, Colorado, New Mexico, Kansas, Oklahoma, Texas, Illinois, Kansas, Idaho, Nebraska, Montana). * Consider themselves to be in good health. * Willing to continue to use their current cosmetic products (foundation, blush, eyeshadow, sunscreen, etc.) and with the same routine/frequency if they do not contain anti-aging ingredients. * Willing to refrain from using AHA, other peeling acids (PHA, BHA), prescription products such as retinoids or hydroquinone etc. during the study. * Willing to take skin swabs to support measures of the skin microbiome. * Must understand their role in the study, provide written informed consent, and fully participate over the 14-week period. * Willing to use the products provided within the study as instructed. Willing to change their current skincare routine and replace it with the given regimen for 14 weeks. * Willing to maintain diet and lifestyle (including physical exercise) during study period. Exclusion Criteria: * Used any of the products to be tested in the claim study in the past 3 months. - Participation in a similar skin study within the past 30 days. * Have active skin disorders such as psoriasis, eczema, allergies, wounds, scars, or severe acne on their forehead. * Regular use of probiotic supplements * Consumption of fermented foods (including kefir, probiotic containing yoghurt, kombucha or other) for more than 5 times a week * Are orally or topically using or have used in the past 6 months: antibiotics, NSAIDS, antihistamines, immuno-suppressants, corticosteroids, prescription products such as retinoids, hydroquinone, or strong AHA treatments. * Have started hormonal treatment (e.g., contraceptives, fertility treatments, or HRT for menopause) within the past 3 months or in case they are on a treatment for more than 3 months they are unwilling to maintain a stable regimen for the duration of the study. * Pregnant or breastfeeding. * Any history of significant disease or medical condition to alter skin appearances such as type 2 diabetes, cancer, renal disorders or hepatic dysfunction. * Individuals who have had medical procedures in their face such as laser resurfacing (or any type of laser treatment ex. photo depilation), plastic surgery (including Botox) within the last 12 months or history of UV radiation (tanning and facial lamps) within the last 3 months. * Active Vitiligo or any other chronic skin conditions. * Individuals with any history that, in the investigator's opinion, indicates potential harm to the subject or could jeopardize the validity of the study. * History of poor cooperation, non-compliance, unreliability, or unwillingness to follow the research protocol and timeline.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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How to take part

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  1. The official record

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