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Can a collagen combo beat wrinkles better than one alone?

NCT ID NCT07473037

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether using both an oral collagen supplement and a topical collagen serum together reduces signs of skin aging more than using either product alone. It involves 165 women aged 45-60 with visible wrinkles and firmness loss. The main focus is on crow's feet wrinkles after 13 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
collagen (oral supplement and topical serum)
What this could lead to
If it works, this could show that using both oral and topical collagen together is more effective for reducing wrinkles than using either alone.
What could go wrong
This is a small, early-stage study (165 women) that hasn't started yet. Results may not apply to all skin types or ages, and the effect may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 165 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 60 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant having signed an Informed Consent Form (ICF) before any trial related activity is carried out; * Female participant; * Participant with a Fitzpatrick skin type I to III; * Participant aged 45 to 60 years inclusive at the time of signing the ICF; * Participant with a BMI ≥20 and \< 29 kg/m²; * Participant presenting: * Cheek firmness score ≥3 and ≤6 on the 10-point scale; * Crow's feet wrinkle score ≥2 and ≤4 on the L'Oréal Atlas; * Global facial wrinkle score ≥3 and ≤6 on the 10-point scale. * Female participant of childbearing potential must use one of the reliable methods of contraception during the investigation and agree not to change it during the study; A woman is considered of childbearing potential unless she is: * Postmenopausal for at least 12 months prior to screening visit; * Without uterus and/or both ovaries; * Has been surgically sterile for at least 6 months prior to Screening visit. * Participant must agree to use only the designated products * Participant willing and able to comply with all study procedures, lifestyle and dietary restrictions, and complete the entire study period * Participant affiliated to a health social security system (according to French Law). Exclusion Criteria: * Participant who is pregnant or who is breast feeding; * Participant receiving hormone replacement therapy (HRT). * Participant who smokes more than two cigarettes per week; * Participant whose alcohol intake exceeds 2 drinks per week; * Participant with any uncontrolled diseases such as diabetes, hypertension, hyperthyroidism or hypothyroidism; * Presenting or having a history of eating disorder (e.g. anorexia, food allergy) or gastro-intestinal malabsorption such as celiac disease, Crohn's disease, lactose intolerance; * Participant with an history of sleeve or bypass; * Participant with skin abnormalities (e.g., scars, excessive hair, tattooing) or any dermatosis (e.g., psoriasis, eczema, acne vulgaris) on the face which could interfere with the study; * Participant with history of any severe disease or current condition which, in the opinion of the Investigator would put the participant at risk by participating in the study or would interfere significantly with the evaluation of study results * Participant with known or suspected hypersensitivity to any ingredient(s) of the investigational products; * Participants having undergone any aesthetic procedures (such as chemical peels, laser treatments, dermabrasions, injections, anti-ageing masks, hair implants, etc.) on the test areas within 6 months prior to the start of the study are excluded. * Participant who, in the opinion of the investigator, is unlikely to comply with the Clinical Study Protocol (e.g., alcoholism, drug dependency or psychotic state); * Participant having use systemic corticosteroids, immunosuppressive drugs, or retinoids (oral or topical) within 3 months prior to study enrollment; * Only for participants (20 in each group) who are willing to accept skin microbiopsies: The participant who has a contraindication to skin biopsies * Participant impossible to contact in case of emergency; * Participant with current participation in any other interventional clinical study, based on interview of the Participant; * Participant who is in an exclusion period in the National Biomedical Research Register of the French Ministry of Health at randomization; * Participant who has been deprived of their freedom by administrative or legal decision, or who is under care of a guardian or legal guardianship, or Participant hospitalized in a medical or social establishment for any reason.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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