Can a collagen combo beat wrinkles better than one alone?
NCT ID NCT07473037
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether using both an oral collagen supplement and a topical collagen serum together reduces signs of skin aging more than using either product alone. It involves 165 women aged 45-60 with visible wrinkles and firmness loss. The main focus is on crow's feet wrinkles after 13 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- collagen (oral supplement and topical serum)
- What this could lead to
- If it works, this could show that using both oral and topical collagen together is more effective for reducing wrinkles than using either alone.
- What could go wrong
- This is a small, early-stage study (165 women) that hasn't started yet. Results may not apply to all skin types or ages, and the effect may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 165 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participant having signed an Informed Consent Form (ICF) before any trial related activity is carried out; * Female participant; * Participant with a Fitzpatrick skin type I to III; * Participant aged 45 to 60 years inclusive at the time of signing the ICF; * Participant with a BMI ≥20 and \< 29 kg/m²; * Participant presenting: * Cheek firmness score ≥3 and ≤6 on the 10-point scale; * Crow's feet wrinkle score ≥2 and ≤4 on the L'Oréal Atlas; * Global facial wrinkle score ≥3 and ≤6 on the 10-point scale. * Female participant of childbearing potential must use one of the reliable methods of contraception during the investigation and agree not to change it during the study; A woman is considered of childbearing potential unless she is: * Postmenopausal for at least 12 months prior to screening visit; * Without uterus and/or both ovaries; * Has been surgically sterile for at least 6 months prior to Screening visit. * Participant must agree to use only the designated products * Participant willing and able to comply with all study procedures, lifestyle and dietary restrictions, and complete the entire study period * Participant affiliated to a health social security system (according to French Law). Exclusion Criteria: * Participant who is pregnant or who is breast feeding; * Participant receiving hormone replacement therapy (HRT). * Participant who smokes more than two cigarettes per week; * Participant whose alcohol intake exceeds 2 drinks per week; * Participant with any uncontrolled diseases such as diabetes, hypertension, hyperthyroidism or hypothyroidism; * Presenting or having a history of eating disorder (e.g. anorexia, food allergy) or gastro-intestinal malabsorption such as celiac disease, Crohn's disease, lactose intolerance; * Participant with an history of sleeve or bypass; * Participant with skin abnormalities (e.g., scars, excessive hair, tattooing) or any dermatosis (e.g., psoriasis, eczema, acne vulgaris) on the face which could interfere with the study; * Participant with history of any severe disease or current condition which, in the opinion of the Investigator would put the participant at risk by participating in the study or would interfere significantly with the evaluation of study results * Participant with known or suspected hypersensitivity to any ingredient(s) of the investigational products; * Participants having undergone any aesthetic procedures (such as chemical peels, laser treatments, dermabrasions, injections, anti-ageing masks, hair implants, etc.) on the test areas within 6 months prior to the start of the study are excluded. * Participant who, in the opinion of the investigator, is unlikely to comply with the Clinical Study Protocol (e.g., alcoholism, drug dependency or psychotic state); * Participant having use systemic corticosteroids, immunosuppressive drugs, or retinoids (oral or topical) within 3 months prior to study enrollment; * Only for participants (20 in each group) who are willing to accept skin microbiopsies: The participant who has a contraindication to skin biopsies * Participant impossible to contact in case of emergency; * Participant with current participation in any other interventional clinical study, based on interview of the Participant; * Participant who is in an exclusion period in the National Biomedical Research Register of the French Ministry of Health at randomization; * Participant who has been deprived of their freedom by administrative or legal decision, or who is under care of a guardian or legal guardianship, or Participant hospitalized in a medical or social establishment for any reason.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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