Can a lower dose of acne drug work just as well with fewer side effects?
NCT ID NCT07639073
First seen Jun 14, 2026 · Last updated Jun 21, 2026 · Updated 2 times
Summary
This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne improvement and any side effects over the treatment period.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Pakistan Institute of Medical Sciences(PIMS)
Islamabad, Pakistan
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isotretinoin (also known as Accutane or Roaccutane)
What this could lead to
If successful, this could show that a lower dose of isotretinoin works just as well as the standard dose but with fewer side effects like dry skin and chapped lips.
What could go wrong
This is a small, early-phase trial (164 participants) in one country, so results may not apply to everyone. Lower doses might not clear acne as effectively, and side effects could still occur.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.