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New hair loss drug shows promise in large global trial

NCT ID NCT04006457

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called PF-06651600 in over 1,000 adults and teenagers with alopecia areata, a condition that causes patchy or complete hair loss. The goal was to see if the drug is safe and helps hair grow back over the long term. A smaller group also checked how well the drug works with routine vaccines. The study is now complete.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,057 people

The number who actually took part.

Started

Jul 2019

Finished

Feb 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria- For de novo participants and participants from Study B7931005 and B7981015 with \>30 days between first visit in B7981032 and last dose in the prior study: * Clinical diagnosis of alopecia areata (AA) with no other cause of hair loss. Androgenetic alopecia coexistent with AA is allowed. * De novo participants \>=12 to \<18 years of age: \>=50% terminal hair loss of the scalp due to AA, including alopecia totalis and alopecia universalis * De novo participants \>=18 years of age and participants from Study B7931005 or B7981015 with \>30 days between first visit in B7981032 and last dose in the prior study: \>=25% terminal hair loss of the scalp due to AA, including alopecia totalis and alopecia universalis * No evidence of terminal scalp hair regrowth within 6 months (de novo only) * Current episode of terminal scalp hair loss \<=10 years (de novo only) Exclusion Criteria- For de novo participants and participants from Study B7931005 and B7981015 with \>30 days between first visit in B7981032 and last dose in the prior study: * Hearing loss with progression over previous 5 years, or sudden hearing loss, or middle or inner ear disease, or other auditory condition that is considered acute, fluctuating or progressive * History of or current malignancies with the exception of adequately treated or excised non metastatic basal cell or squamous cell cancer of the skin or cervical carcinoma in situ * History of a single episode of disseminated herpes zoster or disseminated herpes simplex, or a history of more than one episode of localized, dermatomal herpes zoster * Infection requiring hospitalization, or parenteral antimicrobial therapy within 6 months prior to Day 1 Exclusion criteria for all participants: \- Participants who have previously taken Janus kinase (JAK) inhibitors other than PF-06651600 must have received the last dose \>12 weeks prior to the screening visit

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Conditions

The condition(s) this trial relates to.

alopecia alopecia areata alopecia universalis congenita

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alopecia areata

Contacts and locations

Locations

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050, China

  • CINME Centro de Investigaciones Metabolicas

    CABA, Buenos Aires, C1027AAP, Argentina

  • Centermed Krakow Sp.z o.o.

    Krakow, 31-530, Poland

  • Centre de Recherche Dermatologique du Quebec metropolitain (CRDQ)

    Québec, Quebec, G1V 4X7, Canada

  • Centro Internacional de Estudios Clinicos - CIEC

    Santiago, Recoleta, 8420383, Chile

  • Centro Medico Skin Med

    Santiago, LAS Condes, 7580206, Chile

  • Centro de Investigacion en Reumatologia y Especialidades Medicas S.A.S, CIREEM S.A.S

    Bogota D.C., 110221, Colombia

  • Centrum Medyczne OPOROW

    Wroclaw, 52-416, Poland

  • Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301, Taiwan

  • Chang Gung Medical Foundation Linkou Chang Gung Memorial Hospital

    Taoyuan City, 333, Taiwan

  • Chung-Shan Medical University Hospital

    Taichung, R.o.c., 40201, Taiwan

  • Cityclinic Przychodnia Lekarsko Psychologiczna Matusiak Spółka Partnerska

    Wroclaw, 50-566, Poland

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Clinica Dermacross S.A.

    Santiago, Vitacura, 7640881, Chile

  • Clintrial s.r.o.

    Prague, 100 00, Czechia

  • DERMAMEDICA s.r.o.

    Náchod, 547 01, Czechia

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana, 46250, United States

  • Dermatology Specialists Inc.

    Murrieta, California, 92562, United States

  • Dermedic Jacek Zdybski

    Ostrowiec Świętokrzyski, 27-400, Poland

  • Dermoklinika Centrum Medyczne s.c. M.Kierstan, J. Narbutt, A. Lesiak

    Lodz, 90-436, Poland

  • EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej we Wroclawiu

    Wroclaw, 50-220, Poland

  • ETG Warszawa

    Warsaw, 02-793, Poland

  • Eastern Canada Cutaneous Research Associates Ltd.

    Halifax, Nova Scotia, B3H 1Z2, Canada

  • Emovis GmbH

    Berlin, 10629, Germany

  • FSBEI HE Russian University of Medicine of the MoH of Russia

    Moscow, 111398, Russia

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455, Germany

  • Fakultni nemocnice Olomouc

    Olomouc, 779 00, Czechia

  • Federal State Autonomous Institution "National Medical Research Centre of Children's' Health"

    Moscow, 119991, Russia

  • ForCare Clinical Research

    Tampa, Florida, 33613, United States

  • Fundacion Centro de Investigacion Clinica CIC

    Medellín, Antioquia, 050001, Colombia

  • Fundacion Hospitalaria San Vicente de Paul

    Medellín, Antioquia, 050010, Colombia

  • Guenther Research Inc

    London, Ontario, N6A 3H7, Canada

  • Guy's and St Thomas Hospitals NHS Foundation Trust, St Thomas Hospital

    London, SE1 7EH, United Kingdom

  • Guy's and St Thomas' Hospitals NHS Foundation Trust, Guy's Hospital

    London, SE1 9RT, United Kingdom

  • Guy's and St Thomas' Hospitals NHS Foundation Trust, St Thomas' Hospital

    London, SE1 7EH, United Kingdom

  • Hamamatsu University Hospital

    Hamamatsu, Shizuoka, 431-3192, Japan

  • Hospital D Maria

    Veracruz, 91910, Mexico

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Hospital Universitario Infanta Leonor

    Madrid, 28031, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario La Paz: Servicio de Farmacia

    Madrid, 28046, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario y Politecnico La Fe

    Valencia, 46026, Spain

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Innovaderm Research Inc.

    Montreal, Quebec, H2X 2V1, Canada

  • Juntendo Tokyo Koto Geriatric Medical Center

    Koto-ku, Tokyo, 136-0075, Japan

  • Kaiser Permanente Clinical Trials Unit

    San Francisco, California, 94118, United States

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807, Taiwan

  • Kyorin University Hospital

    Mitaka-shi, Tokyo, 181-8611, Japan

  • Limited Liability Company "Centre Vitiligo" ("Centre Vitiligo" LLC)

    Saint Petersburg, 191123, Russia

  • Limited Liability Company "Pierre Volkenshtein Skin Diseases Clinic"

    Saint Petersburg, 191123, Russia

  • Lynderm Research Inc.

    Markham, Ontario, L3P 1X3, Canada

  • Magdalena Opadczuk Carpe Diem Centrum Medycyny Estetycznej

    Warsaw, 02-661, Poland

  • Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS)

    Boston, Massachusetts, 02114, United States

  • McBk S.C.

    Grodzisk Mazowiecki, 05-825, Poland

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical Skin Center

    Viña del Mar, 2542577, Chile

  • Medstar Georgetown University Hospital - Department of Dermatology

    Chevy Chase, Maryland, 20815, United States

  • Medstar Georgetown University Hospital - Department of Otolaryngology

    Washington D.C., District of Columbia, 20007, United States

  • Medstar Georgetown University Hospital - Department of Pediatrics

    Washington D.C., District of Columbia, 20016, United States

  • Medstar Georgetown University Hospital-Dept of Otolaryngology

    Washington D.C., District of Columbia, 20007, United States

  • Mosaic Dermatology

    Beverly Hills, California, 90211, United States

  • NHS Greater Glasgow and Clyde, Queen Elizabeth University Hospital

    Glasgow, G51 4TF, United Kingdom

  • NYU School of Medicine, The Ronald O. Perelman Department of Dermatology

    New York, New York, 10016, United States

  • Nagoya City University Hospital

    Nagoya, Aichi-ken, 467-8602, Japan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • NorthShore University HealthSystem Dermatology Clinical Trials Unit

    Skokie, Illinois, 60077, United States

  • Northwestern Medical Group

    Chicago, Illinois, 60611, United States

  • Northwestern Medicine

    Chicago, Illinois, 60611, United States

  • Northwestern Medicine Diagnostic Testing Center

    Chicago, Illinois, 60611, United States

  • Northwestern Memorial Hospital Investigational Drug Service Pharmacy

    Chicago, Illinois, 60611, United States

  • Oregon Medical Research Center

    Portland, Oregon, 97201, United States

  • Osaka Metropolitan University Hospital

    Osaka, 545-8586, Japan

  • Park Avenue Dermatology

    Orange Park, Florida, 32073, United States

  • Peking University Third Hospital

    Beijing, Beijing Municipality, 100191, China

  • Premier Specialists Pty Ltd

    Kogarah, New South Wales, 2217, Australia

  • Psoriahue Medicina Interdisciplinaria

    CABA, C1425DKG, Argentina

  • Pura Dermatology (in c/o TrialSpark, Inc)

    New York, New York, 10018, United States

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • RCMed Oddzial Warszawa

    Warsaw, 00-892, Poland

  • Research Toronto

    Toronto, Ontario, M4W 2N4, Canada

  • Royal Melbourne Hospital

    Parkville, Victoria, 3050, Australia

  • Royalderm Agnieszka Nawrocka

    Warsaw, 02-962, Poland

  • Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine

    Shanghai, Shanghai Municipality, 200025, China

  • SKiN Centre for Dermatology

    Peterborough, Ontario, K9J 5K2, Canada

  • Saint Petersburg State Budgetary Healthcare Institution "Dermatovenerologic Dispensary No. 10 -

    Saint Petersburg, 194021, Russia

  • Sanatorium profesora Arenbergera

    Prague, 110 00, Czechia

  • Schweiger Dermatology, P.C.

    Verona, New Jersey, 07044, United States

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Sinclair Dermatology

    East Melbourne, Victoria, 3002, Australia

  • Siperstein Dermatology Group

    Boynton Beach, Florida, 33472, United States

  • Skin Health Institute

    Carlton, Victoria, 3053, Australia

  • Skin Specialists, PC (Schlessinger MD)

    Omaha, Nebraska, 68144, United States

  • Sociedad de Metabolismo y Corazon S.C.

    Veracruz, 91900, Mexico

  • Southern California Dermatology, Inc.

    Santa Ana, California, 92701, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • St George Dermatology & Skin Cancer Centre

    Kogarah, New South Wales, 2217, Australia

  • State Autonomous Healthcare Institution of the Yaroslavl Region "Clinical Emergency Hospital

    Yaroslavl, 150003, Russia

  • State Budgetary Healthcare Institution "Chelyabinsk Regional Clinical Dermatovenerologic Dispensary"

    Chelyabinsk, 454092, Russia

  • State Budgetary Institution of the Rostov Region "Dermatovenerologic Dispensary"

    Rostov-on-Don, 344002, Russia

  • Sudbury Skin Clinique

    Greater Sudbury, Ontario, P3C 1X8, Canada

  • Summit Dermatology and Aesthetic Surgery (in c/o TrialSpark, Inc)

    Oakbrook Terrace, Illinois, 60181, United States

  • Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare

    New Taipei City, 23561, Taiwan

  • Tamjidi Skin Institute (in c/o TrialSpark, Inc)

    Vienna, Virginia, 22182, United States

  • The Centre for Clinical Trials

    Oakville, Ontario, L6J 7W5, Canada

  • The First Affiliated Hospital of College of Medicine, Zhejiang University

    Hangzhou, Zhejiang, 310003, China

  • The First Affiliated Hospital with Nanjing Medical University

    Nanjing, Jiangsu, 210029, China

  • The First Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 510080, China

  • The Skin Centre

    Benowa, Queensland, 4217, Australia

  • The University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • The University of Alabama at Birmingham Hosptial Outreach Lab

    Birmingham, Alabama, 35233, United States

  • The University of Alabama at Birmingham, Department of Dermatology

    Birmingham, Alabama, 35294, United States

  • The University of Hong Kong - Shenzhen Hospital

    Shenzhen, Guangdong, 518053, China

  • The University of Texas Health Science Center at Houston

    Bellaire, Texas, 77401, United States

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574, Japan

  • Tokyo Medical University Hospital

    Tokyo, 160-0023, Japan

  • Twoja Przychodnia SCM

    Szczecin, West Pomeranian Voivodeship, 71-500, Poland

  • UNC CTRC

    Chapel Hill, North Carolina, 27514, United States

  • UNC Dermatology and Skin Cancer Center

    Chapel Hill, North Carolina, 27516, United States

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • Univ of California, Irvine, Dermatology Clinical Research Center

    Irvine, California, 92697, United States

  • Universitaetsklinikum Erlangen

    Erlangen, 91054, Germany

  • University Clinic of Kirov SMU

    Kirov, 610035, Russia

  • University Hospital Frankfurt

    Frankfurt am Main, 60590, Germany

  • University Hospital Muenster

    Münster, 48149, Germany

  • University Hospital Schleswig-Holstein

    Lübeck, 23538, Germany

  • University Hospital Southampton NHS Foundation Trust

    Southampton, Hampshire, SO14 0YG, United Kingdom

  • University Hospital Southampton NHS Foundation Trust

    Southampton, Hampshire, SO16 6YD, United Kingdom

  • University Hospitals Sussex NHS Foundation Trust (UHSussex)

    Brighton, BN2 1ES, United Kingdom

  • University of California, San Francisco

    San Francisco, California, 94115, United States

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • University of Colorado Hospital Clinical and Translational Research Center

    Aurora, Colorado, 80045, United States

  • University of Colorado Hospital Outpatient Pavilion

    Aurora, Colorado, 80045, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Minnesota Clinical Research Unit (CRU)

    Minneapolis, Minnesota, 55455, United States

  • University of Minnesota Lillehei Clinical Research Unit (LCRU)

    Minneapolis, Minnesota, 55455, United States

  • University of Minnesota Medical Center, Investigational Drug Services Attn: Darlette Luke

    Minneapolis, Minnesota, 55455, United States

  • Velocity Clinical Research - Boise

    Meridian, Idaho, 83642, United States

  • Veracity Clinical Research Pty Ltd

    Woolloongabba, Queensland, 4102, Australia

  • Vital Prospects Clinical Research Institute, P.C.

    Tulsa, Oklahoma, 74136, United States

  • Wiseman Dermatology Research Inc.

    Winnipeg, Manitoba, R3M 3Z4, Canada

  • Yale School of Medicine, Yale Center for Clinical Investigations

    New Haven, Connecticut, 06519, United States

  • York Dermatology Clinic and Research Centre

    Richmond Hill, Ontario, L4C 9M7, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.