Breast cancer

This trial tests whether MR-guided focused ultrasound can safely and effectively treat early breast cancer. The procedure uses MRI images to target and heat tumors with ultrasound waves, destroying them without surgery. Participants are women with a single small breast tumor that…

This early-phase study tested a personalized vaccine made from a patient's own immune cells, designed to target a protein called HER-2 found on some aggressive breast cancers. The goal was to see if the vaccine was safe and could train the immune system to prevent the cancer from…

Researchers are testing whether adding the immunotherapy drug tislelizumab to standard TAC chemotherapy helps shrink triple-negative breast cancer before surgery. The trial enrolls 36 women with newly diagnosed triple-negative breast cancer. Participants receive six cycles of tis…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested whether adding the drug nintedanib to standard chemotherapy (docetaxel) helps people with advanced HER2-negative breast cancer live longer without their disease getting worse. Fifty-one adults who had already received some treatment took part. The goal was to se…

Researchers are testing whether adding simvastatin, a widely used cholesterol-lowering drug, to zoledronic acid helps women with breast cancer that has spread to bone. Thirty-five women who have already received chemotherapy receive either simvastatin or a placebo alongside zoled…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin) helps people with metastatic triple-negative breast cancer live longer without their disease getting worse. About 78 participants with advanced cancer that has spread will rece…

This phase II trial tests whether giving a combination of inetetamab, pyrotinib, and nab-paclitaxel before surgery can eliminate cancer in women with HER2-positive early or locally advanced breast cancer. Participants receive four cycles of the drugs, then undergo surgery. The ma…

Researchers are testing whether a device called ExAblate MRgFUS can safely and completely destroy small breast cancers using focused ultrasound waves guided by MRI. The trial enrolls women with a single invasive breast tumor smaller than 2 centimeters who are already scheduled fo…

This phase III trial compares two radiation schedules for women with high-risk breast cancer who have had a mastectomy. One group receives hypofractionated radiation, which uses fewer but larger daily doses over a shorter period. The other receives conventional radiation, with sm…

This trial tests an experimental drug called zanidatamab, which targets HER2, a protein that fuels certain breast and stomach cancers. Researchers give zanidatamab alongside chemotherapy, and sometimes with the immunotherapy tislelizumab, to people with advanced HER2-positive bre…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests three different schedules of the chemotherapy drug nab-paclitaxel (Abraxane) in women with HER2-negative metastatic breast cancer. The goal is to find a schedule that allows patients to stay on treatment longer, potentially improving progression-free survival, wh…

This phase III trial tests whether taking letrozole continuously for five years is better than taking it in cycles with breaks, for postmenopausal women who have already had 4 to 6 years of hormone therapy for early-stage, hormone-receptor-positive breast cancer. Letrozole works …

This phase II trial tested the drug alisertib, alone or combined with fulvestrant, in 96 postmenopausal women with advanced breast cancer that no longer responds to hormone therapy. Alisertib blocks enzymes that help cancer cells grow, while fulvestrant blocks estrogen. The goal …

This study tests whether dietary nitrate from beetroot juice can disrupt the altered metabolism of breast cancer cells. Researchers will give a concentrated beetroot juice drink for five days to patients scheduled for breast cancer surgery. Using advanced MRI scans, they will mea…

This study tests whether giving 6 months of hormone therapy before surgery helps remove all cancer cells in women with early-stage, estrogen-positive breast cancer. It involves 8 postmenopausal women with low-risk, node-negative tumors. The goal is to see if this approach leads t…

This phase II trial is testing whether a combination of palbociclib (a targeted pill), hormone therapy, and HER2-targeted drugs can shrink early-stage breast tumors as effectively as standard chemotherapy before surgery. Postmenopausal women with hormone receptor-positive, HER2-p…

This study looked at whether shutting down the ovaries (ovarian suppression) combined with hormone therapy (tamoxifen or exemestane) could better prevent breast cancer from coming back in premenopausal women with hormone-sensitive breast cancer. Over 3,000 women who had surgery t…

This trial is testing whether combining palbociclib and fulvestrant can help postmenopausal women with a specific type of advanced breast cancer (ER+/HER2-) that has stopped responding to prior treatments. The study aims to see how long the cancer stays under control and to look …

This trial is testing whether adding an experimental drug called BYL719 to standard hormone therapy (letrozole) can better fight hormone receptor-positive metastatic breast cancer in post-menopausal women. BYL719 targets a protein that helps cancer cells grow, while letrozole blo…

This early-stage trial is testing an experimental drug called BEBT-209 in women with advanced HR+/HER2- breast cancer. The study aims to find the safest dose and see how well the drug works, both on its own and when combined with standard hormone therapies like letrozole or fulve…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This trial is testing whether choosing chemotherapy based on the genetic profile of a patient's breast tumor can improve treatment response compared to standard chemotherapy. Women with HER2-negative breast cancer that is not eligible for conservative surgery will be randomly ass…

This trial is testing whether a radioactive tracer, technetium Tc 99m sulfur colloid, can accurately locate sentinel lymph nodes in women with early-stage breast cancer. The sentinel node is the first lymph node cancer is likely to spread to, and finding it helps guide surgery. T…

This trial tests whether giving radiation to the nipple and areola after a nipple-sparing mastectomy is safe and feasible for women with early-stage breast cancer. The goal is to see if this extra radiation can reduce the risk of cancer returning in the preserved nipple area, all…

This phase III trial is investigating whether adding lapatinib to the standard combination of paclitaxel and trastuzumab before surgery can improve outcomes for patients with HER2-positive stage II or III breast cancer. The study aims to see if the three-drug regimen leads to a h…

This trial tests whether giving goserelin, a hormone-blocking drug, alongside chemotherapy can help preserve ovarian function and fertility in premenopausal women with breast cancer. Participants receive either chemotherapy plus goserelin or chemotherapy alone. Researchers will m…

This phase 2 trial compares three hormone therapies—fulvestrant, anastrozole, and tamoxifen—in women with invasive lobular breast cancer, a subtype that is often treated the same as more common breast cancers despite limited evidence. Participants take one of the drugs for about …

This phase III trial is testing whether a combination of docetaxel and cyclophosphamide works as well as or better than anthracycline-based chemotherapy (like doxorubicin) for women with HER2-negative breast cancer that has spread to lymph nodes or is high-risk. The study aims to…

This study tests whether a combination of ribociclib (a targeted pill) and hormone therapy can shrink tumors faster and more effectively than chemotherapy in women with a fast-growing type of advanced breast cancer (HR-positive, HER2-negative). Participants receive ribociclib plu…

This completed phase 3 trial tested whether a single, high-dose radiation boost (6 Gy in one session) is as good as the standard 5-session boost (10 Gy total) after whole-breast radiation in 132 breast cancer patients who had breast-conserving surgery. The main goal was to see if…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can eliminate all signs of cancer in people with early-stage triple-negative breast cancer before they have surgery. About 31 participants with small tumors (1 to 2.5 cm) that haven't sp…

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…

This study tests whether doing Pilates exercises three times a week for 12 weeks can improve bone density in breast cancer survivors aged 40-60 who are taking hormone therapy (aromatase inhibitors). These women are at higher risk for bone loss and osteoporosis. The trial will mea…

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This trial tests whether an accelerated radiation schedule of 5 sessions over 10-12 days works as well as the standard 15-session schedule for women who have had breast-conserving surgery for breast cancer. The study measures breast shape changes two years after treatment. If the…

This phase 2 trial is testing whether a combination of two chemotherapy drugs (nab-paclitaxel and cisplatin) plus an immunotherapy drug (camrelizumab) can help people with metastatic triple-negative breast cancer live longer without their disease getting worse. The study enrolls …

This phase 3 trial compares two treatment approaches for women aged 70 and older with estrogen-receptor-positive, HER2-negative breast cancer. Participants receive either hormone therapy alone for five years or chemotherapy followed by hormone therapy. The study aims to see if ad…

This study tests whether a program of motivational counseling to follow diet and exercise guidelines helps women newly diagnosed with breast cancer complete their chemotherapy and hormone therapy as planned. About 173 women scheduled for chemotherapy will be randomly assigned to …

This trial tests a new way to deliver radiation after breast cancer surgery. Instead of using a single treatment plan for the whole course, the Ethos system creates a new plan each day based on the patient's current anatomy. The goal is to avoid delays caused by changes in breast…

This trial tests a device called SELENE that gives surgeons a detailed view of the tissue removed during breast-conserving surgery. The goal is to see if using this imaging helps surgeons remove all cancer cells the first time, reducing the chance that a patient needs another ope…

This trial investigates whether a structured exercise program can improve fitness and lower risk factors for heart disease, stroke, and type 2 diabetes in Latina women who have had breast cancer. Participants are randomly assigned to either an 8-month progressive exercise program…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This study tested the safety of combining two drugs, alpelisib and fulvestrant, in 40 men and post-menopausal women with a certain type of advanced breast cancer (HR+, HER2-, with a PIK3CA mutation) that had worsened after hormone therapy. The goal was to track side effects. The …

This trial tests a surgical technique for breast reconstruction that uses a tiny camera (endoscope) to help the surgeon harvest muscle and skin from the back through a smaller cut. The goal is to rebuild the breast after cancer or burn injuries while leaving a less noticeable sca…

This trial tests an experimental drug called TQB2102 for people with HER2-positive breast cancer that has returned or spread to other parts of the body. TQB2102 is an antibody-drug conjugate—a targeted therapy that binds to HER2 on cancer cells and releases a potent chemotherapy …

This study tested whether a single dose of the bone drug zoledronate works as well as doses given every six months for three years in women with early-stage breast cancer. The goal was to see if a simpler schedule is feasible and could reduce side effects. The trial enrolled 211 …

This trial tests whether freezing a small, low-risk breast tumor (cryoablation) can control the cancer as well as surgical removal. About 200 women with invasive ductal breast cancer tumors 1.5 cm or smaller will receive cryoablation and be followed for 5 years to check for local…

This study follows 66 women with stage II/III breast cancer who received a natural supplement called PG2 (from astragalus root) alongside their standard chemotherapy. Researchers want to see if PG2 helps delay cancer recurrence or spread, and whether it improves survival. The goa…

This trial investigates whether adding everolimus (RAD001) to trastuzumab (Herceptin) can help people with a specific type of advanced breast cancer that has stopped responding to trastuzumab alone. The study includes people with HER2-positive, PTEN-deficient metastatic breast ca…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tested whether Naderin, an immune-boosting drug, could prevent low white blood cell counts in 79 women with breast cancer receiving first-line chemotherapy. Participants either received Naderin alongside chemotherapy or chemotherapy alone. The results showed that only …

This Phase 2 trial tested whether disulfiram (Antabuse), a drug used for alcoholism, combined with copper supplements could help people with metastatic breast cancer who had run out of standard options. Only 9 patients took part, and researchers measured tumor response and surviv…

This large phase III trial tests which of three chemotherapy drugs—paclitaxel, nab-paclitaxel, or ixabepilone—works best, with or without the targeted drug bevacizumab, for people with stage IIIC or IV breast cancer that has returned or spread. The study aims to find the most eff…

This trial investigates whether structured exercise—either aerobic cycling or resistance training—can improve health-related biomarkers in women with breast cancer undergoing neoadjuvant therapy (chemotherapy or endocrine therapy before surgery). The main focus is on changes in K…

This study tested whether atorvastatin, a cholesterol-lowering drug, can protect the heart in breast cancer patients receiving doxorubicin-based chemotherapy. 44 women with newly diagnosed breast cancer took atorvastatin daily for 3 months alongside their chemo. Researchers measu…

This Phase 1 trial tested an investigational oral drug called CFI-402257 in 52 people with advanced solid tumors, including breast cancer, that had stopped responding to standard treatments. The main goal was to find a safe dose and check how the drug moves through the body. It w…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This phase II trial tested whether combining the immunotherapy drug pembrolizumab (Keytruda) with the chemotherapy carboplatin could help people with HER2-negative metastatic breast cancer that has spread. The 12 participants had cancer cells in their blood and had already tried …

This study tested whether dapagliflozin (Farxiga), a drug used for diabetes and heart failure, can prevent heart damage caused by anthracycline chemotherapy. 94 adults with cancer took either dapagliflozin or a placebo daily for four months alongside their chemo. Researchers meas…

This trial compares a standard mastectomy closure to a technique that adds padding stitches between the skin and chest muscle, aiming to reduce lymphoceles (painful fluid pockets). About 90 women with breast cancer undergoing mastectomy will be randomly assigned to one of the two…

This phase II trial tested a combination of two targeted antibodies (pertuzumab and trastuzumab) plus a chemotherapy drug (nab-paclitaxel) in 63 patients with HER2-positive advanced breast cancer. The goal was to see how well the drugs work together to stop tumor growth and impro…

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This trial studies whether breast-conserving surgery (lumpectomy) followed by radiation is a safe and effective option for women aged 40 and older who have two or more breast cancer tumors in the same breast. The goal is to see if this less invasive approach can control the cance…

This early-phase trial tested whether using mathematical models to schedule chemotherapy drugs docetaxel and epirubicin could reduce severe side effects in 17 patients with metastatic breast cancer. The goal was to find the safest dose and schedule while still giving six cycles o…

This study looked at whether a special needle device (vacuum-assisted biopsy) can completely remove small breast cancers using ultrasound guidance, instead of traditional surgery. 45 women with small, early-stage breast cancers participated. The goal was to see if this less invas…

This study tested whether taking oral chemotherapy pills (vinorelbine or capecitabine) along with the targeted drug trastuzumab can help prevent breast cancer from coming back in women with small, HER2-positive tumors that have not spread to lymph nodes. The 182 participants took…

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This phase 2 trial tested a drug called patritumab deruxtecan (HER3-DXd) in 63 patients with breast cancer, lung cancer, or other solid tumors that had spread to the brain or the lining of the brain and spinal cord. The drug is designed to seek out and destroy cancer cells carryi…

This study tested a new surgical method for immediate breast reconstruction after preventive mastectomy in women at high genetic risk for breast cancer. Instead of a scar on the breast, surgeons used a single-port endoscope through the armpit to place the implant under the skin, …

This study tested whether a single, precise dose of radiation from a CyberKnife robot could replace multiple standard boost treatments after whole-breast radiation in 29 women with early-stage breast cancer. The goal was to reduce skin side effects like redness and swelling while…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy (bevacizumab and paclitaxel) helps people with a certain type of advanced breast cancer (HR-positive, HER2-negative). The trial enrolled 281 participants whose cancer had spread or could…

This study tested a type of breast cancer surgery called nipple-sparing mastectomy, where the breast tissue is removed but the nipple and skin are kept. It involved 450 women with early-stage breast cancer who needed a full mastectomy. The goal was to see if this surgery keeps th…

This trial tests an experimental drug called ARV-471, alone or with another drug (palbociclib), in 217 people with advanced ER+/HER2- breast cancer that has stopped responding to standard treatments. The goal is to see if it is safe and can shrink tumors or slow the disease. The …

This study tested a new two-drug combination (samuraciclib and elacestrant) in 49 adults with a common type of advanced breast cancer (HR+/HER2-). The goal was to find a safe dose and see if it can slow the cancer's growth. Participants had already tried other treatments and thei…

This study tested whether a device that uses focused ultrasound can safely and temporarily open the blood-brain barrier in people with HER2-positive breast cancer that has spread to the brain. Eight participants received the procedure, and researchers checked for side effects and…

This study tested a new drug called giredestrant against the standard drug tamoxifen in 92 premenopausal women with a common type of early breast cancer. Participants took the medication for 15 days before their planned surgery. The goal was to see how well each drug slowed tumor…

This early-phase trial tested a new drug, ipatasertib, added to two existing breast cancer medicines (trastuzumab and pertuzumab) in 17 people with advanced HER2-positive breast cancer that has a specific genetic change (PIK3CA mutation). The main goal was to find the safest dose…

This study looked at whether a test called RAD51-foci can predict how well the drug olaparib works in people with advanced HER2-negative breast cancer who have certain gene mutations (BRCA1, BRCA2, PALB2, RAD51C, or RAD51D). About 65 participants received olaparib, and researcher…

This first-in-human trial tested personalized RNA vaccines designed to target each patient's unique tumor mutations in triple negative breast cancer (TNBC). 42 participants received two custom-made vaccines to stimulate their immune system. The main goal was to check safety and t…

This study tested whether giving vitamin D based on a patient's deficiency level works better than a standard dose. 215 breast cancer patients on chemotherapy received either a fixed daily supplement or a tailored dose. The goal was to see which method normalizes vitamin D levels…

This study tested whether adding a low-dose chemotherapy pill (capecitabine) to standard hormone therapy (aromatase inhibitor) helps women with a common type of advanced breast cancer live longer without the disease getting worse. The trial involved 263 women who had not received…

This study looked at whether adding focused radiation to the cancer spots (metastases) can help people with breast cancer that has spread to a few places (up to 5 spots). 87 participants received either standard drug therapy alone or standard therapy plus radiation. The goal was …

This study tested a new drug called giredestrant, alone or with triptorelin, against a standard treatment (anastrozole plus triptorelin) in 231 premenopausal women with early-stage, hormone-sensitive breast cancer. The goal was to see how well the drugs slow tumor growth before s…

This study tested a breast reconstruction method for women who had a mastectomy, with or without radiation. Surgeons first used fat grafting to prepare the chest wall, then placed a breast implant just under the skin (not under the muscle) to reduce pain and animation. The study …

This Phase 3 trial compared the pill olaparib to standard chemotherapy in 302 people with metastatic breast cancer who have inherited BRCA1 or BRCA2 mutations. The goal was to see if olaparib could slow cancer growth better than chemo. Participants took olaparib twice daily or re…

This early-stage study tested the drug palbociclib (combined with letrozole) in 26 postmenopausal Chinese women with a specific type of advanced breast cancer (ER+, HER2-). The main goal was to see how the drug moves through the body and to check for safety. The study is complete…

This study looked at two different hormone therapy combinations for premenopausal women with a type of breast cancer that grows in response to hormones. Over 2,600 women who had surgery to remove their cancer were randomly assigned to receive either exemestane plus triptorelin or…

This study looked at how well the drug ribociclib works in real-world settings for Indian women with a common type of advanced breast cancer (HR+, HER2-). Researchers reviewed medical records of 335 patients treated across 18 sites in India. The goal was to measure how long the d…

This study tested a drug called alpelisib combined with hormone therapy (fulvestrant or letrozole) in 383 people with advanced breast cancer that has a specific genetic change (PIK3CA mutation). The goal was to see how many patients were alive without their cancer getting worse a…

This phase II trial tested a 9-day course of whole breast radiation (hypofractionated radiotherapy) in 102 patients with early-stage breast cancer (stage 0-IIB). The goal was to see if a shorter treatment time could maintain effectiveness while reducing side effects. Researchers …

This study tested whether adding the experimental drug samuraciclib to standard hormone therapy (fulvestrant) works better than fulvestrant alone for people with advanced HR+/HER2- breast cancer. The trial enrolled 60 adults whose cancer had worsened despite prior treatment. Rese…

This study tested giving a single, targeted dose of radiation directly to the tumor site during breast cancer surgery, followed by standard radiation. Over 1,100 patients with small tumors were followed for years to see if the cancer came back. The goal was to improve local contr…

This study tested two treatment plans for people with advanced HR-positive, HER2-negative breast cancer that is aggressive. One group received a drug called abemaciclib plus hormone therapy. The other group started with a short course of chemotherapy, then switched to abemaciclib…

This completed study tested whether a shorter, more intense course of radiation (1 week) works as well as the standard 3-week course for women with early breast cancer after lumpectomy. Sixty women were split into two groups to compare side effects, cosmetic results, and cancer c…

This early-phase trial tested a personalized immunotherapy for people with advanced solid tumors. Doctors removed a sample of each patient's tumor, grew the immune cells (TILs) in a lab, and then infused them back along with another drug. The goal was to see if this approach is s…

This phase 2 trial tested whether adding loperamide (Imodium) and a white blood cell booster (G-CSF) could reduce severe diarrhea and low white blood cell counts caused by the drug Trodelvy in people with advanced breast cancer. Fifty patients with metastatic triple-negative or l…

This early-phase trial tested a new drug called CyPep-1, injected directly into tumors, combined with the immunotherapy pembrolizumab (Keytruda) in 6 people with advanced head and neck cancer, melanoma, or triple-negative breast cancer. The main goal was to check safety and side …

This study tested whether adding the drug pertuzumab to standard chemotherapy and trastuzumab could help prevent breast cancer from returning after surgery. About 4,800 people with HER2-positive breast cancer took part. The results showed that the three-drug combination improved …

This early-stage trial tested the drug olaparib (a PARP inhibitor) given alongside radiation therapy for people with triple-negative breast cancer that is advanced or has come back. The main goal was to find the safest dose of olaparib when used with radiation, and to watch for s…

This study tested a new way to give the drug trastuzumab (Herceptin) to women with HER2-positive breast cancer that had spread to the lining of the brain. Instead of through a vein, the drug was injected directly into the spinal fluid via a lumbar puncture or a special reservoir.…

This study tested a new strategy for people with a common type of advanced breast cancer (ER+, HER2-). It used a blood test to look for a gene change (ESR1 mutation) that can make cancer stop responding to the first hormone therapy. When the mutation appeared, some patients switc…

This early-phase study tested a new drug called LY3484356 in 87 postmenopausal women with early-stage, hormone-receptor-positive breast cancer. The goal was to see if the drug is safe and how it affects cancer cells before the participants had surgery. The study lasted up to 2.5 …

This study tested a lower starting dose (400 mg) of the targeted drug ribociclib combined with standard hormone therapy (letrozole or anastrozole) in 376 women with advanced hormone receptor-positive, HER2-negative breast cancer. The goal was to see if the lower dose could contro…

This early-phase study tested whether the heart medication carvedilol could safely protect breast cancer patients from heart damage caused by chemotherapy drugs like doxorubicin and trastuzumab. 68 women with early-stage breast cancer were assigned to either receive carvedilol or…

This study tested a procedure called radiofrequency ablation, which uses heat from a needle to destroy breast tumors, combined with hormone therapy. It included 21 elderly patients (over 70) who either declined or were not candidates for surgery. The main goal was to see if the c…

This study tested whether a program of regular geriatric checkups, nutrition support, and weekly Tai Chi classes could help women over 70 with breast cancer stay on their hormone therapy. The 12 participants had their blood tested over 3 years to see if they were taking their med…

This early-phase trial tested a new combination of two drugs (ARV-471 and everolimus) in 32 people with a common type of advanced breast cancer (ER+/HER2-). The main goals were to find the safest dose and check for side effects. Researchers also looked at whether the tumors shran…

This study looked at combining the drug abemaciclib with standard hormone therapy as a first treatment for women with metastatic breast cancer that has spread to organs or has a high tumor burden. The goal was to see how many patients' tumors shrank or disappeared. The study enro…

This Phase 3 trial compares a new hormone therapy pill called elacestrant to standard treatments (fulvestrant or aromatase inhibitors) in 478 people with ER+/HER2- advanced breast cancer that worsened after prior CDK4/6 inhibitor therapy. The study measures how long the cancer st…

This completed Phase 2 trial tested whether adding atorvastatin (a cholesterol-lowering drug) to standard hormone therapy (letrozole or fulvestrant) could improve outcomes in 126 women with advanced, hormone-receptor-positive breast cancer. The main goal was to see if the combina…

This early study tested a combination of a modified herpes virus (T-VEC) and an immunotherapy drug (atezolizumab) in 28 women with aggressive breast cancer that did not fully disappear after standard chemotherapy. The virus was injected directly into tumors to kill cancer cells a…

This study tests whether contrast-enhanced mammography (CEM) can safely reduce the number of breast biopsies for women with breast findings that are suspicious but not highly suspicious (BI-RADS 4A or 4B). About 2,100 women scheduled for a biopsy will first get a CEM. The goal is…

This study is testing whether an artificial intelligence program called Mirai can better identify women at high risk for breast cancer compared to traditional risk models. Researchers will invite 200 women flagged as high-risk by Mirai to receive an additional breast MRI. The goa…

Researchers are testing whether a standard MRI scanner can be used to create detailed 3D maps of fat molecules in the breast. The idea is that changes in fat composition may appear before cancer develops, so this could help detect very early breast cancers. The study will compare…

Researchers are testing whether a special MRI technique that maps fat composition in breast tissue can improve early detection of breast cancer. The study compares women with a BRCA1/2 or TP53 gene mutation, who are at high risk, with women who already have invasive ductal carcin…

This trial is testing whether contrast enhanced mammography (CEM) can find additional breast cancers that standard imaging might miss in women already recalled for further testing after a screening mammogram. Women with a suspicious finding will receive an extra CEM scan alongsid…

This trial is testing whether a new PET imaging agent called NeoB can more accurately detect the spread of a certain type of breast cancer (ER/PR positive, HER2 negative) compared to conventional scans like CT, bone scans, and FDG PET/CT. The study will enroll 20 women with metas…

This study investigates whether a protein called FGF19, normally found in the intestine and gallbladder, appears at higher levels in the blood of people with breast or colorectal cancer compared to healthy individuals. Researchers will measure FGF19 and related markers in fasting…

This study tested a new radioactive tracer called 99mTc-ZHER2:41071 in 30 women with breast cancer. The tracer is designed to attach to HER2 proteins on cancer cells, allowing doctors to see them on a SPECT scan. The goal was to see how the tracer spreads in the body, how safe it…

This completed phase 1 trial tested a radioactive imaging agent called [99mTc]Tc-DB8 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help detect tumors using SPECT scans. Researchers also checked for safety and…

This completed study tested a new radioactive imaging agent called 99mTc-ADAPT6 to see if it can detect HER2 protein in breast cancer tumors using SPECT scans. Sixteen women with primary breast cancer received a single injection, followed by scans over six hours. The goal was to …

This completed phase 1 study tested a new radioactive imaging agent called 99mTc-RM26 in 10 people with prostate or breast cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors using SPECT scans. Researchers also checked for safety and …

This completed Phase 1 trial tested a new radioactive tracer called 99mTc-HE3-G3 to see if it can safely and accurately detect HER2 protein in breast cancer tumors using SPECT imaging. Thirty adults with primary breast cancer received one injection of the tracer, followed by scan…

This study tested a new imaging method that uses a radioactive tracer to detect HER2 protein in breast cancer tumors and nearby lymph nodes. 24 women with primary breast cancer received one injection followed by a scan. The goal was to see if the scan results matched standard tis…

This study tested a new imaging agent called 99mTc-ADAPT6 in 30 women with breast cancer that had spread to lymph nodes. The agent is designed to attach to HER2 proteins on cancer cells, allowing doctors to see them on a SPECT scan. The goal was to see if the scan results matched…

This study tested a new radioactive imaging agent that binds to the HER2 protein, which is important for guiding breast cancer treatment. Ten women with known HER2-positive or HER2-negative breast cancer received one injection of the agent, followed by several SPECT scans over 24…

This early study tested a new radioactive imaging agent, called [123I] I-(HE)3-G3, to see if it can safely detect HER2 protein in breast cancer tumors using SPECT scans. Ten people with either HER2-positive or HER2-negative breast cancer received one injection and were scanned ov…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether a gene test called MammaPrint can help doctors decide which breast cancer patients need chemotherapy before surgery. The goal is to shrink tumors enough so that patients can have less invasive surgery, like a lumpectomy instead of a mastectomy. The study…

This pilot study tested a new radioactive tracer called 89Zr-DFO*-trastuzumab in 6 people with HER2-positive breast or gastric cancer. The tracer is designed to attach to HER2 proteins on cancer cells and show up on PET scans. Participants received one injection and had up to 4 P…

This study looked at whether a special type of mammogram called contrast-enhanced mammography (CEM) can be used instead of MRI to screen for breast cancer in women at high risk. The study included 615 women who could not have an MRI due to reasons like claustrophobia or implants.…

This study aimed to create easy, non-invasive tests using blood and saliva to find markers of certain cancers, like breast and lung cancer. Researchers worked with 250 adults who had these cancers but hadn't started treatment yet. The goal was to improve early detection and monit…

This study tested a new way to tell breast cancer types apart using a special ultrasound, instead of a tissue biopsy. Researchers looked at blood vessel patterns in tumors from 94 patients and built a tool to predict whether the cancer was luminal or non-luminal. The goal is to h…

This study tested whether using contrast-enhanced mammography to guide breast biopsies is more accurate than the standard X-ray-guided method for suspicious calcifications. About 184 women with suspicious calcifications (BIRADS R3-R5) were randomly assigned to one of the two biop…

This completed study tested a special dye called TTP-ICG that sticks to breast cancer cells. After removing tissue, doctors soaked it in the dye and used a special camera to see if cancer cells were left at the edges or in lymph nodes. The goal was to help surgeons know right awa…

This study looked at whether a small, portable ultrasound device can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) breast lumps in women who had a positive clinical breast exam. Researchers tested the device on 150 women, using standard i…

This large study tested whether artificial intelligence (AI) can make mammography screening better. Over 100,000 women were randomly assigned to have their mammograms read with AI assistance or by the usual two radiologists. The goal was to see if AI could catch more cancers, red…

This study tested a new, noninvasive method called SAVE to help classify breast masses as benign or malignant. Researchers at Mayo Clinic enrolled 266 women with breast lesions to see how well the SAVE method could tell cancerous from non-cancerous masses. The goal is to provide …

This study tested whether a special PET scan (called 18F-DOPA PET-CT) can find brain metastases as well as or better than standard MRI in people with lung cancer, breast cancer, or melanoma. 32 adults with untreated brain metastases took part. The goal was to see if this PET meth…

This study tested an artificial intelligence (AI) tool called Carebot AI MMG to see how well it can find breast lesions and measure breast density from mammograms. Researchers compared the AI's accuracy to that of human doctors using 122 mammogram studies. The goal was to see if …

This study looked at how many tissue samples are needed when doing a special type of breast biopsy called contrast-enhanced stereotactic biopsy (CESB). The biopsy is used for breast lesions that only show up on contrast-enhanced mammography. Researchers studied 77 women to find t…

This study tested an AI system called Carebot AI MMG to see if it can detect breast cancer from mammograms as accurately as human radiologists. Researchers looked at 222 past mammograms from four screening centers. The AI classified each exam as low, medium, or high risk, and its…

This study tested whether a special 3D ultrasound technique, called shear wave elastography, can predict how well breast cancer responds to chemotherapy before surgery. Researchers measured tumor stiffness in 140 women with locally advanced breast cancer at several points during …

This study looked at whether an MRI can detect breast cancer in women who have abnormal nipple discharge but normal mammograms and ultrasounds. 70 women with single-pore, non-milky, non-green discharge were given an MRI. The goal was to see how often a normal MRI meant no cancer …

This study tested whether a fluorescent dye called indocyanine green (ICG) can help surgeons locate small, non-palpable breast tumors during surgery. Ten women with early-stage breast cancer received both the dye and a standard radioactive seed, and doctors compared how well each…

This study explored whether breast cancer has a unique smell that can be detected. Researchers used a special polymer (Sorbstar®) and trained dogs to sniff samples from 35 women before and after tumor removal. The goal was to see if a distinct scent signature exists, which could …

Researchers are testing three ways to deliver the same breast cancer and early-detection education to adult women: a private Instagram account, a dedicated website, and an electronic brochure sent through WhatsApp. A fourth group receives no education. The study measures whether …

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

This trial tests whether a simple, non-invasive abdominal massage can prevent constipation in breast cancer patients undergoing chemotherapy. Constipation is a common and distressing side effect of chemo, affecting up to 90% of patients. The study will compare patients who receiv…

This trial tests whether memantine, a drug used for Alzheimer's disease, can prevent the chronic nerve pain that sometimes develops after breast cancer surgery. Half of the participants receive memantine for four weeks, starting two weeks before their operation, while the other h…

This trial investigates whether sulindac, an NSAID, can reduce breast density in postmenopausal women at elevated risk for breast cancer. High breast density is a known risk factor for the disease. Participants take sulindac or a placebo daily for 12 months, and changes in breast…

This study tests whether simple nudges—like text message reminders for patients and automatic mammogram orders for doctors—can increase breast cancer screening among women aged 40 to 74 who are overdue for a mammogram. The trial involves over 21,000 women at two health systems. S…

This pilot study tested whether a diet designed to lower insulin levels could reduce breast cancer risk in 34 high-risk women. The diet is rich in fruits, vegetables, whole grains, and plant protein, and low in animal protein and fat. The main goal was to see if women could stick…

This small pilot study tested whether an ice plant cream could prevent hand-foot syndrome (pain, redness, peeling on hands and feet) in 15 breast cancer patients receiving doxorubicin or docetaxel chemotherapy. The main goal was to see if a larger study is possible, not to prove …

This study looked at whether teaching women simple self-massage and stretching exercises before and after breast cancer surgery could prevent long-term pain. 143 women took part. Half received standard care, and the other half also attended workshops to learn these techniques and…

This study looked at whether time-restricted eating (eating only during a set window each day) can lower biological and behavioral risk factors for breast cancer. It involved 178 women aged 50 or older with metabolic issues like prediabetes or type 2 diabetes. Participants follow…

Researchers are testing an 8-session mindfulness-based self-compassion program for women diagnosed with breast cancer. The program combines meditation, yoga, and homework to help participants focus on the present moment. The trial measures changes in self-esteem and spiritual wel…

This study follows 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life over time. Researchers want to understand how well patients tolerate this treatment and how it affects t…

This study looked at whether giving a specific type of numbing medicine (called PECS) during mastectomy surgery can lower the chance of having chronic pain 6 months later. It included 194 women having a breast removed, with or without lymph node removal or reconstruction. The goa…

This trial tests whether an 8-week behavioral activation program can reduce cancer-related fatigue in women who have had surgery for stage I-III breast cancer. Participants are randomly assigned to receive the program plus usual care, or usual care alone. The study measures fatig…

Researchers compare two ultrasound-guided nerve block techniques to see which controls pain better after modified radical mastectomy, a common breast cancer operation. The study enrolls 86 adults scheduled for the surgery. One group receives an erector spinae plane block, the oth…

This study tested whether a web-based exercise program could reduce nerve pain and improve quality of life in breast cancer patients receiving chemotherapy. 90 patients with stage II-III breast cancer and neuropathy symptoms took part. The program was guided by a physiotherapist …

Researchers are testing whether an ultrasound-guided paravertebral nerve block, given before general anesthesia, reduces the amount of opioid painkiller needed during a mastectomy. The study enrolls 40 women with breast cancer who are scheduled for unilateral mastectomy, with or …

Researchers are testing three non-drug approaches for nerve pain caused by paclitaxel, a common chemotherapy for breast cancer. The trial enrolls 140 women receiving weekly paclitaxel who develop mild nerve symptoms. Participants are assigned to TENS, compression, cryotherapy, or…

This study tests whether a program of specific shoulder exercises can improve muscle function and reduce pain in women who have had a mastectomy. Sixty women aged 35-55 with shoulder problems will be enrolled. The exercises focus on strengthening and stabilizing the shoulder blad…

This trial compares two ultrasound-guided pain relief techniques for women undergoing breast-conserving surgery for cancer: a serratus anterior plane block and a thoracic epidural. Both use the local anesthetic bupivacaine to numb nerves and reduce post-operative pain. The study …

This study tested three different nerve block methods to manage pain after a double mastectomy with immediate reconstruction. Over 1,500 women received either a paravertebral block, a serratus+PECS-1 block, or a combination. The goal was to see which approach reduces the need for…

This trial tests whether a single 600 mg dose of gabapentin, taken one hour before breast cancer surgery, reduces the amount of morphine needed for pain afterward. Sixty women scheduled for elective breast surgery will be randomly assigned to receive either gabapentin or a placeb…

This trial tests two types of nerve blocks for pain after breast cancer surgery. One method targets a deeper layer of muscle, while the other combines both superficial and deep layers. The goal is to see which approach better reduces pain, cuts down on opioid use, and improves co…

This trial tests whether a self-management program can reduce lymphedema symptoms and improve quality of life in women with breast cancer who have developed arm swelling after mastectomy. Participants will learn exercises and receive education on lymphedema care, such as skin pro…

This trial compares two anesthesia approaches for women having a mastectomy for breast cancer. One group receives opioid-free anesthesia with a pectoral nerve block, while the other receives standard opioid-based anesthesia with fentanyl. Researchers measure CD4+ T-cell counts be…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This pilot trial tests whether a brief virtual reality (VR) experience can help breast cancer patients feel calmer in the waiting period just before surgery. Sixty women scheduled for breast cancer surgery will be randomly assigned to either an 8-minute guided mindfulness meditat…

This trial compares two ultrasound-guided nerve block techniques for pain relief after breast cancer surgery. It aims to see which method better controls pain, reduces opioid use, and improves recovery in women undergoing a mastectomy. Participants will receive one of the two blo…

This trial tests whether a gentle, non-invasive device called mindvybe can improve wellbeing in people who have had breast cancer. The device delivers mild electrical stimulation near the vagus nerve on the ears and neck, plus specific earlobe points. About 60 adults who finished…

This study tests whether a conversation game called 'Hello' can help people with cancer and their loved ones discuss advance care planning—decisions about future medical care. Participants will play either the Hello game or a similar conversation game, complete questionnaires, an…

This study tests an 8-week telehealth occupational therapy program designed to help breast cancer survivors increase physical activity after breast-conserving surgery or mastectomy. The program is delivered via Zoom and focuses on each survivor's preferred activities. Researchers…

This pilot study explores whether cancer patients are willing to complete a quick self-screening for insomnia during clinic visits, and whether a video-based cognitive behavioral therapy (CBT-I) could help them sleep better. The study involves adults with breast, colorectal, lung…

This early-stage trial is testing whether a topical solution containing calcitriol, a form of vitamin D, can safely reduce hair loss in adults receiving taxane-based chemotherapy for breast, gynecologic, or other solid tumors. Participants apply the solution to their scalp twice …

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This study looks at a breast reconstruction method that uses only a small part of a back muscle, aiming to reduce shoulder pain and stiffness. Researchers will compare this technique to standard implant reconstruction in about 190 women. The goal is to see which approach gives be…

This trial tests whether a cream made with mushroom extracts can help protect the skin of women undergoing radiation therapy for breast cancer. Participants use the cream or a standard moisturizer on the treated breast twice daily, starting before radiation and continuing for a m…

This study tests whether using virtual reality glasses or doing breathing exercises during chemotherapy can help reduce anxiety in breast cancer patients. Participants will be divided into three groups: one using VR glasses, one doing guided breathing exercises, and one receiving…

This trial tests whether myofascial chain release techniques—gentle manual therapy targeting the connective tissue around muscles—can improve shoulder range of motion in women who have had a mastectomy for breast cancer. Participants will receive either standard physiotherapy or …

This trial tests whether applying a hyaluronic acid gel (Endotra Gel) to the breathing tube before general anesthesia can reduce sore throat, hoarseness, and coughing after breast cancer surgery. About 132 adults undergoing breast cancer surgery will be randomly assigned to recei…

This trial tests whether a web-based education program can improve body image, self-esteem, and quality of life in women with breast cancer who lose their hair during chemotherapy. The program provides information on hair loss, scalp care, wigs, and emotional coping strategies. R…

This trial tests whether a four-week mindfulness program, delivered by a nurse, can reduce psychological distress and increase hope and mindfulness in women with breast cancer receiving radiotherapy. One hundred women who had mastectomy and are now undergoing radiotherapy are ran…

This trial tests whether practicing Tai-Chi can help reduce fatigue in breast cancer patients receiving chemotherapy. Participants are randomly assigned to either routine care alone or routine care plus Tai-Chi practice five times a week for three weeks. Fatigue levels are measur…

This study tests whether a 12-week community program combining supervised physical exercise (Nordic walking and Tai Chi) with health education workshops can improve quality of life and reduce fatigue in women with metastatic breast cancer who are receiving active treatment. Parti…

This trial investigates whether a supervised program of aerobic and strength exercises can improve or prevent lymphedema—a painful arm swelling—in women who have had breast cancer treatment. Participants are assigned to either an exercise group or a no-exercise control group. Res…

This trial tests a digital application designed to help surgeons explain breast cancer surgery to patients. The goal is to see if using the app during the first consultation makes patients feel their doctor is more empathetic and empowers them in decision-making. The study involv…

This study explores whether a tablet-based cognitive stimulation program called HAPPYNeuron® is practical for breast cancer patients aged 70 and older. Cancer treatments, especially chemotherapy, can cause memory and thinking problems, and older patients may be at higher risk. Th…

This study tested a device called Papillon +TM that delivers a single dose of radiation directly to the tumor site during breast cancer surgery. 28 women aged 60 and older with early-stage breast cancer took part. The main goal was to see if the technique was feasible and safe, n…

This study explores whether a 12-week program combining cognitive stimulation sessions and adapted physical activity, done at home with remote supervision, is feasible for women who have cognitive difficulties after breast cancer treatment. The study includes 20 women with locali…

This trial tests whether a nurse-led communication support program delivered via mobile health tools can improve quality of life and reduce anxiety and depression in women with early-stage breast cancer starting chemotherapy. Participants are randomly assigned to receive either t…

This Phase 3 trial tested whether Nuvastatic, a plant extract, can reduce cancer-related fatigue in 180 women with breast cancer undergoing chemotherapy. Participants took Nuvastatic or a placebo three times daily for three chemo cycles. The study measured fatigue levels and qual…

This study looked at whether e-health tools—like a phone call from a specialist or a self-report app—can help manage pain and anxiety after a breast biopsy. About 193 women took part. The goal was to see if these check-ins lead to less pain and better well-being compared to stand…

This study tested whether EMDR (a therapy using guided eye movements) could help reduce anxiety and depression in women with breast cancer. Fifteen women who had mastectomy for invasive breast cancer received up to 8 sessions of EMDR during their cancer treatment. The main goal w…

This study tested whether a 20-minute virtual reality session before a planning CT scan could lower anxiety in 256 breast or pelvic cancer patients starting radiotherapy. Patients were randomly assigned to either the VR session or usual care. The goal was to see if VR could reduc…

This study tested whether an 8-week online positive psychology program could help women who finished breast cancer treatment feel less afraid of the cancer coming back. 38 women took part, with half attending weekly group sessions on gratitude, optimism, and savoring good moments…

This study tests whether PG2, a compound from the astragalus root, can reduce fatigue and low white blood cell counts caused by chemotherapy in women with stage II or III breast cancer. Participants receive either PG2 or a placebo alongside their standard chemotherapy. The goal i…

This study compared two ways to manage pain during breast cancer surgery: a nerve block (erector spinae plane block) and a lidocaine drip given through a vein. Researchers measured inflammation markers and pain levels in 40 women undergoing surgery. The goal was to see which meth…

This study tested whether a 12-week music listening program could help breast cancer patients with memory and thinking problems caused by chemotherapy. 90 women took part, with half listening to self-chosen music daily for at least 20 minutes plus usual care, and the other half r…

This study tested whether a structured educational program could help women with breast cancer improve their sexual function and better follow their medication plans. Sixty-two women took part, attending sessions about their disease, treatments, side effects, and the importance o…

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study looked at whether fencing can help women who had surgery for breast cancer. Thirty patients took fencing lessons and were checked for improvements in arm function and quality of life. The results were encouraging, suggesting fencing may be a fun way to aid recovery.

This pilot study tested whether a self-management program combining exercise classes and group discussions could relieve joint pain caused by aromatase inhibitors (AI) in older breast cancer survivors. Twelve women aged 60 and older who were starting AI medication took part. The …

This study tested whether wearing special light glasses for 30 minutes each morning could help breast cancer patients feel less tired, sleep better, and think more clearly during treatment. The trial included 260 women with early-stage breast cancer, plus a healthy comparison gro…

This study looked at whether walking, with or without a grounding stick, can reduce pain, fatigue, and improve sleep in women with breast cancer. Fifty-five women who were on chemotherapy took part. They walked for 30 minutes at least three times a week for eight weeks. The goal …

This study looked at 157 women with breast cancer who had a mastectomy. It compared two ways to drain fluid after surgery: active drainage (using suction) and passive drainage (gravity). The goal was to see which method led to less fluid buildup (seroma), shorter drain time, and …

This study tested a hybrid (online and in-person) group education program based on psychodynamic nursing theory for women who had a mastectomy. The goal was to see if it could improve how they value their bodies, reduce anxiety about their appearance, and enhance their sexual qua…

This study tested whether Daflon, a medication usually used for vein problems, can reduce seroma — a common fluid buildup after breast cancer surgery. 190 patients took Daflon or a placebo for four weeks after surgery. The goal was to see if it lowers the chance of seroma forming…

This study tested two non-drug treatments—kinesio taping and low-level laser therapy—on 66 women with arm swelling (lymphedema) after mastectomy for stage II breast cancer. The goal was to see which method better reduced arm size, improved hand grip strength, and eased shoulder p…

This study looked at whether adding nerve mobilization (gentle stretching exercises for nerves) to early physical therapy can reduce long-term shoulder disability in women after breast cancer surgery. 140 women who had surgery for breast cancer took part. The results help underst…

This study looked at whether taking omega-3 fatty acid supplements can reduce joint pain and stiffness caused by aromatase inhibitors, a common hormone therapy for breast cancer. 77 postmenopausal women with early-stage breast cancer or at high risk took omega-3 supplements soon …

This study tested whether a capsaicin skin patch (made from chili peppers) works better than oral pregabalin for treating nerve pain that starts soon after breast cancer surgery. 140 women who had surgery for breast cancer and developed nerve pain within 2 months were enrolled. T…

This study tested whether two nurse phone calls during the first three cycles of chemotherapy could improve the emotional state and quality of life of patients with breast, colon, or rectal cancer. 274 patients were randomly assigned to receive either standard care or standard ca…

This study tested a new type of training called ADIE Therapy for breast cancer survivors who often feel anxious even after treatment ends. The training teaches people to better notice their own heartbeat and other body signals. 21 survivors took part in six sessions to see if the…

This study tested whether Coenzyme Q10, a dietary supplement, can reduce nerve damage, fatigue, and pain in women with newly diagnosed breast cancer receiving paclitaxel chemotherapy. Fifty women took either CoQ10 plus chemotherapy or chemotherapy alone for twelve weeks. Research…

This study tested a program called Maximizing Energy to help women who finished breast cancer treatment manage their fatigue. Fifteen women took part, either in the program or a general health education group, over six online sessions. Researchers checked if women stayed in the s…

This completed study tested a culturally adapted program to help breast cancer patients manage joint and muscle pain caused by hormone therapy. 289 women on aromatase inhibitors received either the tailored program (health education, monitoring, and nursing guidance) or standard …

This study tested whether a personalized telephone-based weight loss program could help reduce fatigue in overweight or obese breast cancer survivors. 220 participants who had finished active treatment for early-stage breast cancer were enrolled. The program provided motivational…

This study tested whether using virtual reality (VR) and music during chemotherapy sessions is practical and helpful for breast cancer patients. Sixty patients were offered VR headsets with calming music and videos while receiving chemo. The goal was to see if patients would use …

This study tested whether personalized remote exercise coaching, using a digital platform and a connected watch, could improve quality of life in 824 breast cancer survivors. Participants were randomly assigned to receive either the coaching or standard advice. The study measured…

This study tested whether a technique called ischemic preconditioning, which is used to protect organs during transplants, could reduce fat tissue damage after breast reconstruction surgery. 18 women who had breast reconstruction using their own belly fat were included. The appro…

This study looked at whether an 8-week virtual program focused on healthy eating and exercise could reduce stress and improve quality of life for breast cancer survivors. Twenty-two adults who had been diagnosed with breast cancer took part in weekly 90-minute online sessions. Re…

This study tested whether a specific meditation technique, Twin Hearts Meditation, could reduce nausea and vomiting caused by chemotherapy in women with breast cancer. 102 women were split into two groups: one practiced meditation for 30 minutes at least three times a week, while…

This study tested whether a 7-day supervised fast (max 350 calories per day) could reduce muscle and joint pain in 54 breast cancer patients taking aromatase inhibitors. The goal was to see if fasting is feasible and improves physical well-being and quality of life. Researchers a…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study tested whether acupuncture can help prevent or reduce nerve pain, numbness, and tingling caused by chemotherapy in people with early-stage breast cancer. 89 participants were split into two groups: one received acupuncture, the other watched nature videos and did relax…

This study looked at whether giving a lower dose of the steroid dexamethasone before the chemotherapy drug docetaxel can prevent allergic reactions with fewer side effects. The standard high dose can cause problems like high blood sugar, mood changes, and weakened immunity. Resea…

This study looked at side effects from a special radiotherapy technique called simultaneous integrated boost (SIB) given after breast-conserving surgery for breast cancer. 93 women were followed to see how well they tolerated the treatment. The goal was to compare side effects wi…

This pilot study looked at whether a supervised or distance-supervised brisk walking program could help manage fatigue in breast cancer patients currently on hormone therapy. Seventeen women who had completed chemotherapy and/or radiation took part in a 6-week program, walking tw…

This study tested whether adding dexmedetomidine (a sedative) to a standard numbing medicine (bupivacaine) in a chest nerve block could improve pain control after breast cancer surgery. Sixty women received either the standard block or the block with added dexmedetomidine. The ma…

This study looked at breast reconstruction using only a patient's own fat (lipomodulin) after mastectomy for breast cancer. Researchers wanted to see how often the procedure works, how the breast looks afterward, and how it affects quality of life. The study included 118 women wh…

This study tested a virtual reality program to help breast cancer patients who have memory or concentration problems after treatment. 23 patients used the VR program for 10-15 minutes each week for 6 weeks. The goal was to see if patients would stick with the program and if it co…

This study looked at whether people with early or locally advanced HER2-positive breast cancer prefer receiving their medication (a combination of pertuzumab and trastuzumab) at home versus in the hospital. About 346 participants were randomly assigned to receive the drug at home…

This study tested whether a mobile app exercise program is practical and helpful for 32 women with breast cancer undergoing chemotherapy. The program included guided exercises and education to improve arm function, fitness, and quality of life. Results will show if this approach …

This study tested whether a combination of slow, guided breathing (called cardiac coherence) and a hypnosis session could help women feel less anxious before breast or gynecologic cancer surgery. Fifty-three women participated, practicing the breathing technique several times a d…

This study tested two types of nerve blocks to control pain after breast cancer surgery. 32 women received one of two ultrasound-guided injections before surgery. The serratus anterior plane block provided better pain relief, lasted longer, and caused fewer side effects like naus…

This study tested whether a yoga program done at home and in group sessions is practical for breast cancer patients on hormone therapy who have joint pain. 24 patients were asked to follow daily home yoga and attend 6 sessions with a therapist. The goal was to see if patients wou…

This study tested two methods for marking non-palpable breast tumors before surgery: a tiny iodine seed versus a standard metal wire. 350 women with early-stage breast cancer took part. The goal was to see if the seed method leads to cleaner surgical margins, potentially reducing…

This study looked at whether a special 'remission' consultation with a psychotherapist can improve quality of life for women who have finished treatment for localized breast cancer. Fifty women who completed chemotherapy or radiotherapy in the last six months were offered this ta…

This study tested a program that teaches couples communication skills when one partner has advanced cancer. About 440 patients and their partners took part, with half receiving the training and half getting general healthy living information. The goal was to see if the training c…

This pilot study tested an online program called THRIVE, based on Positive Affect Training, to help breast cancer survivors feel better about taking their anti-hormonal medication. The goal was to see if the program was acceptable and feasible for women who struggle with side eff…

This study tests whether craniosacral therapy, a gentle hands-on technique, can improve quality of life in women who have finished breast cancer treatment. 102 survivors with reduced well-being are randomly assigned to one-on-one therapy, group self-help training, or a waiting li…

This study tested a special dressing coated with a substance that binds bacteria (DACC-coated hydrogel) to treat skin burns caused by radiation therapy in 18 women with breast cancer. The goal was to see if it could reduce pain and help heal the skin. The study is already complet…

This study tested a manual acupressure technique called Energy Resonance by Cutaneous Stimulation (RESC) to see if it could lower anxiety in 57 women about to undergo a breast macrobiopsy. Participants received a RESC session before the procedure, and their anxiety was measured u…

This study tested whether an online program combining nutrition counseling and resistance training could improve physical function in older adults (65+) who finished treatment for breast, colorectal, or prostate cancer. 75 participants received virtual sessions with dietitians an…

This study looked at whether a structured exercise program (adapted physical activity) could improve thinking and quality of life in women treated for locally advanced breast cancer. 37 women who had chemotherapy and reported memory or concentration problems took part. Half start…

This study tested whether physical therapy and education before breast cancer treatment can help prevent or reduce side effects like joint pain, muscle weakness, and fatigue. 75 newly diagnosed patients were randomly assigned to either the MOve-ABC program (physical therapy, home…

This study looked at whether adding a mindfulness-based stress reduction program to an 8-week exercise plan could improve fitness and quality of life in women with breast cancer. 100 women who had finished chemotherapy and were undergoing radiotherapy or hormone therapy took part…

This study looked at whether ear acupuncture can ease hot flashes in women with breast cancer who are taking hormone-blocking pills. 107 women took part, comparing two types of ear acupuncture. The goal was to see if this simple treatment could improve their daily comfort and qua…

This study tested a mobile health program to help breast cancer patients in medically underserved areas manage pain and disability. 180 women with breast cancer and persistent pain took part in four video-conferencing sessions over eight weeks, learning coping skills from a remot…

This study tested whether telemedicine and connected watches can help monitor symptoms and improve quality of life for women with advanced breast cancer who live far from their cancer center. Fifteen patients reported symptoms weekly on a tablet, while a smartwatch tracked their …

This study tested a 6-week online pain management program for breast cancer survivors who still have bothersome pain after treatment. The program included education, exercises, and psychological strategies to cope with pain. Researchers wanted to see if it helps reduce pain's imp…

This study looked at whether starting a personalized exercise program before breast cancer surgery helps women recover better. Thirty female survivors followed the program for 12 months. The goal was to improve shoulder motion, reduce pain, and enhance daily function and quality …

This study looked at whether a tailored exercise program, done either before or during standard breast cancer treatment, could reduce side effects like heart damage and muscle loss. One hundred women with early-stage breast cancer participated. The goal was to see if exercising b…

This study tested whether a program of therapeutic exercise and relaxation techniques (called ATENTO) could prevent nerve damage (neurotoxicity) in women newly diagnosed with breast cancer. 42 women were split into two groups: one started the program before cancer treatment, the …

This study tested a remote coaching program called PRISM to help women with breast cancer build resilience and improve their quality of life. 43 women with early-stage or metastatic breast cancer took part. The program focused on stress management, goal-setting, and positive thin…

This study tested whether a brief mindfulness program could improve emotional well-being and quality of life in women with early-stage breast cancer. 42 women watched educational videos, listened to guided meditations, and wrote reflections before and after surgery. Researchers m…

This pilot study tested a collagen-based food supplement (Tenflex®) in 30 women with breast cancer who had joint pain from hormone therapy (aromatase inhibitors). The goal was to see if pain levels improved over 12 weeks. The supplement is already sold as a food product, so this …

This study tested whether watching 360° virtual reality movies can reduce fear and anxiety in cancer patients about to start radiation therapy. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched a VR movie and then filled …

This study tested whether a surgical glue called Ifabond can reduce seroma—painful fluid collections—after breast cancer surgery. 104 women having partial mastectomy with or without lymph node removal were randomly assigned to receive standard surgery plus the glue or standard su…

This study tested two skin treatments—a hydrogel dressing and a water spray—for women with breast cancer who developed skin irritation from radiotherapy. The goal was to see which one better prevented treatment delays or the need to switch care. 278 women with mild to moderate sk…

This study tested whether a nerve block using ropivacaine could reduce pain after breast cancer surgery compared to a placebo. 182 women having breast-conserving surgery with sentinel lymph node biopsy took part. The goal was to see if fewer patients needed strong painkillers in …

This study looked at whether giving ketamine during anesthesia can reduce the need for morphine and lower pain after breast cancer surgery. About 230 adults having a mastectomy or lumpectomy took part. The goal was to see if ketamine helps avoid morphine's side effects.

This study tested whether a newer nerve block called ESP works as well as the standard PVB block for pain after breast cancer surgery. 292 women received one of the two blocks before surgery. The main goal was to see how many needed morphine in the first two hours after surgery. …

This study tested whether using augmented virtual reality (AVR) during chemotherapy can help reduce pain, stress, and anxiety while boosting self-confidence. 150 adult cancer patients in the West Bank were split into two groups: one received standard care, and the other used AVR …

This study tested whether auriculotherapy (a form of ear acupuncture) can reduce muscle and joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. 197 postmenopausal women with breast cancer who had pain for at least 3 months were randomly assigned…

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast cancer had a PET scan before and after their first chemo cycle. The goal was to see if the scan could tell responders from non-resp…

This completed study looked at blood and tumor samples from 66 women with breast cancer who were about to receive chemotherapy before surgery. Researchers searched for unique protein patterns that might show whether the tumor would shrink with treatment. The goal was to find a wa…

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast c…

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three yea…

Researchers at Centre Oscar Lambret are studying how immune cells get inside breast and colon tumors. They will analyze stored tumor samples from about 70 patients treated between 2005 and 2007, looking at genes and proteins on blood vessel cells that may control this process. Th…

Researchers want to know how common a BRCA2 gene mutation is among people diagnosed with breast cancer on Reunion Island. Earlier work found that more than half of patients there with a BRCA mutation carry a variant specific to the island's population. This study collects blood s…

This completed study looked at why some women reject personalized breast cancer risk estimates. Researchers gave 781 Black or African American women aged 39-74 a personal risk score based on the Gail Model and asked if they agreed with it. The goal was to understand risk rejectio…

Breast cancer surgery often involves removing lymph nodes from the armpit, which can lead to lasting arm swelling and reduced arm function. This study follows 258 breast cancer patients who have this node removal and compares two groups: those whose surgeons preserve small vein b…

This study looked at how common BRCA1 and BRCA2 gene mutations are in Hispanic/Latino women with breast cancer. Researchers collected saliva samples and medical history from 266 participants to better understand these mutations in this group. No treatment was given; the goal was …

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This completed study looked at how women ages 39-49 make decisions about breast cancer screening. Participants read a decision aid explaining the pros and cons of mammograms and then answered surveys about their reactions, knowledge, and screening plans. The goal was to understan…

This study looks back at the records of 461 women in Brazil who received a short, high-dose radiation schedule after breast cancer surgery. The schedule, called extreme hypofractionation, delivers 5 doses of 5.2 Gy instead of many smaller doses. Researchers want to see how well t…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This study looks at how the adrenal glands work in people who are critically ill, such as those with sepsis. Adrenal insufficiency may affect up to 77% of ICU patients, but current tests are not reliable. Researchers will measure hormone levels in 225 participants, including heal…

This study tested a new cone-beam CT scanner that takes clearer pictures during radiation therapy for lung, liver, and breast cancers. 31 people participated to see if the new scanner reduces image blurring and improves accuracy. The goal is to help doctors target tumors more pre…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study observed over 2,400 women in Russia with advanced HR+/HER2- breast cancer to see how well different treatments work in everyday medical practice. Researchers tracked how long patients stayed on their therapy before it stopped working or caused side effects. The goal wa…

This trial is testing whether contrast-enhanced ultrasound (CEUS) can reliably measure tumor blood flow in people with metastatic cancers like GIST, breast, kidney, colon, rectal, or melanoma. Participants will have two ultrasound scans before starting anti-angiogenic treatment, …

This trial asks whether giving medical students access to large language models (like ChatGPT) helps them choose cancer treatments that align with expert tumor board decisions, compared to using standard treatment guideline PDFs. Around 70 medical students will review case vignet…

This study looked at whether a special website or coaching phone calls could help more people with a personal or family history of certain cancers get genetic testing. Over 800 participants were randomly assigned to one of these two methods or to standard care. The goal was to se…

This study looks back at medical records to see how ribociclib, a CDK4/6 inhibitor used for hormone receptor-positive, HER2-negative metastatic breast cancer, is prescribed and tolerated in older adults (65 and over) and Black/African American patients. These groups are often und…

This study tests whether sending text message reminders to patients and alerts to doctors can increase the number of women who get their recommended mammograms. About 8,490 women aged 40-74 who are overdue for screening will take part. The goal is to see if these simple 'nudges' …

This study tests whether a direct meeting between breast cancer patients and a pathologist—where the pathologist reviews the patient's own pathology slides—can improve the patient's understanding of their disease and sense of empowerment. Participants complete questionnaires befo…

This study gives women over 70 being treated for breast cancer a wrist-worn activity tracker to wear for a year. Researchers will analyze daily step counts and sleep duration to describe different physical activity and sleep profiles. They will also see how these profiles relate …

This study looks at how breast cancer patients' predictions of their quality of life after surgery compare to what they actually experience. Researchers will ask women before and after surgery about their physical and emotional well-being. The goal is to understand if patients' e…

This study observes how Canadian women with a specific type of advanced breast cancer (HR+/HER2-) use the drug palbociclib (Ibrance) as their first treatment. Researchers will measure how long patients stay on the drug and look at treatment patterns in real-world settings, outsid…

This study follows 450 premenopausal women with early-stage hormone-positive breast cancer in Italy. Researchers want to see how adding triptorelin to standard hormone therapy affects quality of life and hormone levels. The goal is to better understand the real-world impact of tr…

This study looks at the risk of interstitial lung disease (ILD) in people with inoperable or recurrent breast cancer who take the drug palbociclib (Ibrance) combined with fulvestrant. Researchers will compare this group to patients taking fulvestrant alone, using data from over 4…

This study investigates whether tumor DNA found in the blood (called plasma tumor DNA or ptDNA) can predict how well breast cancer responds to chemotherapy given before surgery. Researchers will collect blood samples from 228 people with early-stage, high-risk breast cancer (HER2…

This completed study observed 22 adults with HER2-positive or HER2-low metastatic breast cancer who were taking trastuzumab deruxtecan (Enhertu) as part of routine care. Researchers tracked how many patients stopped treatment early or needed dose changes, and why. The goal is to …

This study follows women who had breast cancer surgery to see if the type of anesthesia they received—propofol or sevoflurane—affects cancer recurrence and survival 5 and 10 years later. Only patients from an earlier trial are included. The goal is to understand whether anesthesi…

This study looked at 422 breast cancer patients to understand what influences their beliefs about physical activity and their desire to be active. Researchers measured patients' knowledge of exercise benefits, their current activity levels, and fatigue. The goal was to learn how …

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This pilot study tests a near-infrared (NIR) imaging device that measures oxygen levels in breast skin flaps during and after mastectomy with immediate reconstruction. The goal is to see if the device can reliably detect areas with poor blood flow that might lead to healing probl…

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study looks at whether breast cancer patients with mild, moderate, or severe liver problems face a higher risk of a serious side effect—grade 4 neutropenia (a dangerous drop in infection-fighting white blood cells)—when taking the drug palbociclib. Researchers analyzed medic…

This study looks at medical records from across Europe to see how well a drug combination (palbociclib plus an aromatase inhibitor) works as a first treatment for people with a common type of advanced breast cancer (HR+/HER2-). Researchers want to understand how long the treatmen…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This completed study looked at whether a simple blood test (liquid biopsy) can help track breast, ovarian, and endometrial cancers. Researchers analyzed circulating tumor cells in 150 women to see if these cells could predict the risk of cancer spreading or how well treatment wor…

This study looked at two ways to help breast and ovarian cancer survivors get genetic counseling: a mailed brochure or a phone call with a health coach. About 668 women took part. The goal was to see which method led more people to actually get genetic counseling or testing. The …

This completed study analyzed tissue samples from 108 breast cancer patients to identify proteins linked to early cancer invasion. The goal was to find markers that could help assess the risk of tumor spread in patients without lymph node involvement. Researchers focused on listi…

This study looks at medical records from 750 people with a common type of early breast cancer (HR+/HER2-). It aims to understand how doctors treat these patients in real life, especially after newer targeted drugs called CDK4/6 inhibitors became available. By analyzing treatment …

This study explored whether a simple blood test measuring the neutrophil-to-lymphocyte ratio (NLR) can help predict how well women with advanced breast cancer respond to a common treatment (CDK4/6 inhibitors plus hormone therapy). Researchers followed 165 patients starting this t…

This completed study from the University of Central Florida involved 24 women diagnosed with breast cancer. Through online questionnaires and focus groups on Zoom, researchers explored how the disease and its treatment affect sexual health, intimacy, and relationships. The goal i…

This study measured levels of a protein called IP3R3 in breast cancer tissue from 42 women. The goal was to see if this protein is involved in how cancer cells migrate and invade nearby tissues. Researchers hope this could lead to better understanding of what makes breast cancer …

This study looked at 185 people with a common type of advanced breast cancer (HR+/HER2-) in Africa and the Middle East who were starting treatment with palbociclib combined with hormone therapy. Researchers tracked how long the cancer stayed under control and how patients felt ov…

This study aimed to create a personalized 3D computer model of the breast to help surgeons better understand where tumors are located during surgery. Researchers measured skin elasticity and thickness in 200 women, and performed special MRI scans on 10 women in different position…

This study collected information from 93 men who have had breast cancer. Participants filled out a questionnaire about their life, work, family, and health history. The goal is to find patterns that might help explain why some men develop breast cancer. No treatments or drugs wer…

This study looked at memory complaints in 426 people, including those with brain tumors, breast cancer, and healthy volunteers. Participants filled out questionnaires about their memory, mood, and fatigue. The goal was to understand how cancer and its treatments might affect ever…

This completed study looked at medical records of over 1,100 people in Australia who took CDK4/6 inhibitors (like palbociclib) for advanced or metastatic breast cancer. Researchers wanted to understand patient characteristics, dosing, and how long people stayed on treatment in re…

This study tested whether time-restricted feeding (eating only during an 8-hour window each day) could change certain blood markers linked to breast cancer risk. Twenty-nine postmenopausal women with prediabetes were randomly assigned to either the 8-hour eating schedule or a nor…

This study tested whether an artificial intelligence (AI) model can accurately measure heart rhythm changes (QTc) from ECGs in 70 breast cancer patients starting the drug ribociclib. The goal was to see if simpler ECG devices could work as well as standard 12-lead machines when a…

This study tested whether a two-hour, peer-led workshop with religious messages could encourage Muslim women in North East England and Scotland to get screened for breast, bowel, and cervical cancer. 169 women aged 25-74 who were not up-to-date with all eligible screenings took p…

This study tested a simple, self-administered scoring system to identify moderate to severe nerve damage caused by chemotherapy in breast cancer survivors. 26 women who had taxane-based chemotherapy and radiation took part. The goal was to find the best score that separates those…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study tested a digital health platform to help people with a hereditary risk of breast and ovarian cancer share their genetic test results with family members. Researchers worked with 128 participants in Switzerland and Korea to see if the tool reduced distress and improved …

This study offered a rapid hepatitis C test to 1,500 women aged 50-74 who were already coming in for breast cancer screening in Montpellier, France. The goal was to see how many women would agree to the extra test and how many had undiagnosed hepatitis C. Women who tested positiv…

This study examined whether specific gene variations influence how well metastatic breast cancer patients respond to chemotherapy with or without the drug bevacizumab. Researchers enrolled 307 women from Italy to compare outcomes and analyze genetic interactions. The goal was to …

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This study examined tumor samples from 3,646 women with early-stage breast cancer who had already received chemotherapy after surgery. Researchers measured specific immune cells (tumor-infiltrating lymphocytes and CD8+ T cells) to see if their presence was linked to how long pati…

This completed study looked at 470 women with breast cancer in Paris to understand how their background affects their experience. It compared women born in France with those born in sub-Saharan Africa, focusing on diagnosis timing, treatment access, and social impacts. The goal i…

This study aims to develop and validate a scoring system to identify which patients with metastatic breast cancer are likely to live longer with third-line chemotherapy. Researchers will collect clinical, histological, and biological data from 267 women starting a third line of t…

This study looked at whether it's possible to measure certain substances called oxysterols in the blood of breast cancer patients. 29 women taking hormonal therapy (tamoxifen or anti-aromatase drugs) had their blood tested before and 28 days after starting treatment. The goal was…

This study looked at whether tiny molecules called microRNAs in the blood can help predict if hormone therapy will work for women with advanced breast cancer. Researchers tested blood samples from 39 women before and after one month of treatment with tamoxifen or an aromatase inh…

This completed study involved 775 women who had breast-conserving surgery and radiation for breast cancer. Researchers compared different surgery and radiation techniques to see which ones led to less breast hardening (fibrosis) and better cosmetic results. The goal was to find w…

This study looked at whether using a special ultrasound ruler during breast-conserving surgery helps surgeons remove all cancer the first time. Researchers reviewed records from 273 patients who had this ultrasound-guided surgery. The goal was to see if it lowered the rate of inc…

This study combined data from over 5,300 people with early-stage breast cancer who received a specific type of chemotherapy. Researchers wanted to see how long patients lived without the cancer coming back and what side effects they had. The goal is to learn from past treatments …

This study looked at medical records from over 218,000 adults in England with a common type of breast cancer (HR+/HER2-). Researchers tracked which treatments people received, how the disease progressed over time, and how healthcare resources were used. The goal was to understand…

This study looked at how women aged 65 and older with early-stage breast cancer choose among three options after surgery: standard weeks-long whole-breast radiotherapy, a single dose of radiation during surgery, or no radiation at all. Researchers surveyed 104 patients to underst…

Breast cancer in men is rare, making up only 1% of cases, and most research has focused on women. This study aims to develop a questionnaire specifically for men with breast cancer to measure their quality of life. Researchers interviewed 65 patients and healthcare professionals …

This study looked at how closely 200 adults with advanced breast or prostate cancer follow their prescribed oral cancer treatments. Participants filled out questionnaires about their medication use and gave blood samples to check certain health markers. The goal was to understand…

This completed study looked at whether sampling just a few lymph nodes under the arm can tell if breast cancer has spread, instead of removing many nodes. Twenty patients with advanced breast cancer at diagnosis took part. The goal was to see if this targeted approach could reduc…

This study examined how well CDK4/6 inhibitors (a type of targeted therapy) work for people with advanced breast cancer in Egypt. Researchers looked at 206 patients to measure how long the drugs kept cancer from growing, side effects, and overall costs. The goal was to see if the…

This study measured how much physical activity 507 breast cancer patients in Spain get and what types of exercise they prefer. Researchers used questionnaires to understand current activity levels and exercise likes and dislikes. The goal is to use this information to design bett…

This study used functional MRI (fMRI) to see how the brain's sensory map changes after breast reconstruction in women treated for breast cancer. Researchers compared brain activity when touching the reconstructed breast versus the natural breast. The goal was to objectively measu…

This study looked at spinal fluid from 7 women with breast cancer that may have spread to the lining of the brain. Researchers analyzed proteins in the fluid to see if they can find a pattern that helps diagnose this condition. The goal was to learn more, not to test a treatment.

This completed study looked at how emotional skills affect the way young women (45 or younger) with non-metastatic breast cancer and their partners adjust to the disease. 391 couples filled out questionnaires at several points during treatment, from before chemotherapy to after r…

This completed Phase 3 study looked at how four different hormone therapies (anastrozole, exemestane, letrozole, and tamoxifen) affect memory in postmenopausal women with breast cancer. The 44 participants took one of these drugs for 6 to 12 months, and researchers tested their v…

This study looked at 28 women with breast cancer that spread to their bones. Researchers compared two types of scans—PET-CT and whole-body MRI—to see if they agree on whether the bone tumors are stable, improving, or getting worse. The goal is to find a reliable way to monitor tr…

This study tested a new questionnaire designed to measure quality of life in young women (under 45) with non-metastatic breast cancer and their partners. Over 1,000 couples completed the survey at home. The goal was to see if the questionnaire accurately captures the emotional an…

Researchers developed and tested a short questionnaire called the Cancer Pathology Acceptance Questionnaire for Breast Cancer (CPAQ-8-BC) in 101 women with breast cancer. The goal was to see if it reliably measures how well a patient accepts her illness and stays engaged in life …

This study looked at spinal fluid from 51 breast cancer patients whose cancer may have spread to the lining of the brain and spinal cord (leptomeningeal metastases). Researchers compared a new blood test technique (CellSearch) with standard spinal fluid analysis to see which bett…

This study looked at how breast cancer affects the quality of life of young women (under 45) and their life partners. Researchers interviewed 171 couples at different times during medical follow-up to understand emotional, social, and relationship challenges. The goal was to crea…

This study looked at how calcium and vitamin markers change in 146 breast cancer patients receiving standard adjuvant chemotherapy. Researchers measured these markers before, during, and after treatment to understand metabolic effects. The goal was to see how often patients devel…

This study looked at whether automated planning tools can be used with MRI scans to guide radiation therapy for breast cancer. The goal was to make treatment faster and more precise while avoiding extra radiation from X-rays. 63 female breast cancer patients took part to help ref…

This study tested whether an online decision support tool helps young women (18-40) with breast cancer make more informed choices about preserving their fertility before starting cancer treatment. 186 participants either received standard oral information alone or used the online…

This study tested a digital chatbot (called CATALYST) to help cancer survivors learn about genetic testing for inherited cancer risk. Fifty adults who had certain cancers (like breast, ovarian, or prostate) used the chatbot or received usual care. The goal was to see if the chatb…

This study tested whether a special survivorship clinic, combined with an app for reporting symptoms, is practical for women who have finished curative treatment for early-stage breast, cervical, or endometrial cancer. Two hundred women visited the clinic at the start and end of …

This completed observational study in India enrolled 595 people with HR-positive, HER2-negative advanced or metastatic breast cancer who were already taking alpelisib plus fulvestrant. Researchers looked for PIK3CA gene mutations in tumors and tracked how well the cancer responde…

This study looked at 97 women with early-stage breast cancer who were getting strong chemotherapy. They were given one of two types of G-CSF (a drug that helps the body make more white blood cells) to see which one better prevented dangerously low white blood cell counts. The goa…

This study looked at 27 women with breast cancer who had a mastectomy and immediate breast reconstruction with an implant. The implant was placed either above the chest muscle (prepectoral) or below it (subpectoral). Researchers measured pain, arm function, quality of life, and c…

This completed study tested a web-based decision aid called RealRisks in 70 high-risk women aged 35-74. The tool combines electronic health records and patient-reported data to calculate breast cancer risk and improve understanding of prevention options. Researchers measured whet…

This completed study looked at how physical activity, fitness, and sitting time relate to insulin resistance (a diabetes risk factor) in 40 breast cancer survivors taking hormone therapy. Participants wore activity monitors and underwent tests for fitness, body composition, and i…

This study compared two types of skin grafts (Alloderm and Dermacell) used in immediate breast reconstruction after mastectomy. 62 women participated, and researchers tracked complications like infection, fluid buildup, and implant loss. The goal was to see if the cheaper option …

This study observed over 2,600 women in Germany with a common type of advanced breast cancer (HR+/HER2-). Researchers compared how long the cancer stayed under control when women started treatment with a drug combo (ribociclib plus hormone therapy) versus other hormone therapies …

This study tested a program called KanSurvive, which uses virtual education sessions and practice support to help rural primary care clinics improve follow-up care for cancer survivors. Researchers worked with 15 rural practices to see if they could better follow guidelines for m…

This study looked at 1,000 women who had breast reconstruction with implants right after mastectomy, followed by radiation therapy. Researchers compared two types of implants—polyurethane-covered and non-polyurethane-covered—to see which had fewer complications like capsular cont…

This study involved 155 women with early breast cancer who had been taking hormone therapy for 2-3 years. Researchers wanted to understand how skin-related side effects from the treatment impact their quality of life. Participants filled out questionnaires about their skin sympto…

This study asked 714 breast cancer survivors about their experiences with the COVID-19 vaccine. Researchers wanted to understand if lymph node swelling—a common vaccine side effect—caused worry or raised the risk of lymphedema (arm swelling) in these patients. The study collected…

This study tested a new cone-beam CT scanner designed to take clearer images while patients are on the radiotherapy couch. 41 adults with head-and-neck, lung, breast, abdominal, or pelvic cancer each had one or two scans with the new device. The goal was to see if the images were…

This study looked at 100 women having a mastectomy to see if a device called the Analgesia Nociception Index (ANI) can detect when a nerve block isn't working. The device measures pain signals during general anesthesia. If it works, doctors could adjust pain treatment right away,…

This study looked at 120 women with early-stage breast cancer to see if having low muscle mass (sarcopenia) before treatment raises the risk of nerve damage from the chemotherapy drug paclitaxel. Researchers measured muscle mass on CT scans and checked for nerve symptoms using qu…

This study looked at how breast cancer treatments affect sexual health in 25 women. Participants filled out anonymous questionnaires about their sexual function, quality of life, and emotional well-being before and after chemotherapy. The goal was to understand how these factors …

This study looked at whether giving doctors a free online risk score (PREDICT 2.1) changes how often they order an expensive genetic test called Oncotype DX for early-stage breast cancer. Over 600 patients took part. The goal was to see if the algorithm could help doctors make be…

This study looked at 200 women with early-stage HER2-positive breast cancer who were taking trastuzumab. The goal was to compare two standard schedules for monitoring heart function: every 3 months versus every 4 months. Researchers wanted to see if less frequent monitoring could…

This study asked 167 people with cancer (and their caregivers) what they value most during pharmacy consultations for oral cancer drugs. Using a survey method, researchers identified key preferences to help hospitals design better support services. The goal was to improve patient…

This study tested whether osteopathic manipulative medicine (OMM) — gentle techniques like opening the chest and pumping the armpit — could help dye and radioactive tracer reach lymph nodes better than standard massage alone. 27 women having breast-conserving surgery for first-ti…

This study tested a program for adults aged 65-90 who had breast, colorectal, or prostate cancer. A community health worker assessed their health and provided coaching to address issues often missed after cancer treatment. The goal was to see if the program was feasible and could…

This study tested whether a high-resolution PET-CT scan of the removed tumor during breast-conserving surgery can help surgeons see if any cancer cells remain at the edges. About 206 women with early-stage breast cancer received a low-dose radioactive tracer before surgery. After…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to measure these DNA levels. The goal was to understand the natural pattern of DNA c…

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This study looked at 60 people with metastatic breast cancer to find out whether certain cells in their blood (called DP-circulating cells) come from the tumor. Researchers took a blood sample before starting treatment and checked tumor samples. The goal was to better understand …

This study looked at whether special heart MRI scans can spot early signs of heart damage in breast cancer patients after chemotherapy and radiation. Researchers followed 150 women for 12 months to see if heart swelling predicted a drop in heart function. The goal was to improve …

This study looked at whether giving cancer patients a decision aid before their doctor visit (on a smartphone) or during the visit (on paper) helps them feel more involved in treatment decisions. 274 adults with breast or colorectal cancer took part. The goal was to see which for…

This completed study looked at how CDK4/6 inhibitors are used in everyday practice for advanced breast cancer in Portugal. Researchers analyzed data from 16 public hospitals to understand dosing patterns, treatment duration, and how often doses were adjusted. The study included n…

This study tested a noninvasive imaging method called Diffuse Optical Spectroscopy Imaging (DOSI) to see if it could predict how breast cancer responds to chemotherapy. Twenty-four women with breast cancer were scanned up to 9 times during their treatment. The goal was to see if …

This study reviewed medical records of 111 adults with early-stage HER2-positive breast cancer who received the drug neratinib after their initial treatment. The goal was to describe their age, gender, health conditions, and tumor details. This was an observational study, meaning…

This study looked at whether MRI scans can detect how well breast cancer responds to chemotherapy early in treatment. Sixteen women with invasive breast cancer received standard chemo before surgery, and their MRI results were checked by two radiologists. The goal was to see if M…

This study looked at small molecules called metabolites in breast cancer tumors to find patterns that could help understand the disease better. Researchers analyzed 52 tumor samples and some blood samples from patients who had surgery. The goal was to identify possible biomarkers…

This pilot study measured levels of a heart stress marker called NT-proBNP in 54 breast cancer patients during surgery. All patients had previously received anthracycline chemotherapy, which can weaken the heart. Researchers wanted to see if anesthesia might add extra stress. The…

This study looked at whether sending text message reminders could increase the number of people who take part in colorectal and breast cancer screening programs. Over 44,000 eligible adults were included, and researchers compared SMS reminders to standard letters or no reminder. …

This completed study looked at 261 French cancer patients to understand why many do not exercise, despite evidence that physical activity improves survival and well-being. Researchers surveyed patients about their personality, motivation, anxiety, and social background. The goal …

This study looked at whether patient navigators can help women with breast cancer in Mozambique start treatment sooner. Ninety women received support from trained navigators from admission to their first treatment. Researchers measured time delays and survival rates compared to p…

This study tested a method to identify immune cells (T cells) that recognize unique mutations in tumors. Researchers took blood and lymph node samples from 25 patients with breast cancer or melanoma. The goal was to see if they could find and measure these cancer-specific immune …