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Can exercise tweak tumor biology? new trial tests aerobic vs. resistance training in breast cancer

NCT ID NCT05297773

Disease control Sponsor: Fundacao Champalimaud Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether structured exercise—either aerobic cycling or resistance training—can improve health-related biomarkers in women with breast cancer undergoing neoadjuvant therapy (chemotherapy or endocrine therapy before surgery). The main focus is on changes in Ki-67, a marker of tumor cell growth, along with secondary measures like body composition, fitness, quality of life, and tumor biology. Participants are randomly assigned to aerobic training, resistance training, or a relaxation control group for the duration of their treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise (aerobic training or resistance training)
What this could lead to
If exercise proves beneficial, it could become a standard part of breast cancer treatment to improve outcomes and well-being.
What could go wrong
This is a mid-sized trial, and results may not apply to all patients. Exercise may not significantly affect tumor biology.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

Dec 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically breast cancer (stage 0-III); scheduled for neoadjuvant treatment (cohort A - chemotherapy; cohort B - endocrine therapy) * Women aged ≥ 18 years; nonpregnant * Do not be involved in any structured exercise program in the past 6 months * Medical approval to participate in the study * Willingness to attend exercise sessions Exclusion Criteria: * Treated for any cancer in the past 5 years (except basal cancer) * Uncontrolled heart disease (heart failure, uncontrolled coronary heart disease, and uncontrolled hypertension, cardiac disease) * Diabetes mellitus * Lung condition (chronic obstructive or restrictive pulmonary disease) * Psychological disorders (dementia, Alzheimer, and Parkinson Disease) * Severe disability, or other medical condition that prevents from exercise training * Alcohol or drugs abuse

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm insomnia Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer

Contacts and locations

Locations

  • Faculdade de Motricidade Humana - Universidade de Lisboa

    Lisbon, Cruz-Quebrada, 1495-751, Portugal

  • Fundação Champalimaud

    Lisbon, Lisbon District, 1400-038, Portugal

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