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Exercise program aims to ease joint pain in older breast cancer survivors

NCT ID NCT03955627

Symptom relief Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether a self-management program combining exercise classes and group discussions could relieve joint pain caused by aromatase inhibitors (AI) in older breast cancer survivors. Twelve women aged 60 and older who were starting AI medication took part. The program included 8 weeks of supervised Zoom sessions followed by 8 weeks of home-based exercise with coaching calls. Researchers measured pain levels and medication adherence over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise and education program
What this could lead to
If it works, this could offer a simple, drug-free way to manage joint pain and improve medication adherence in older breast cancer survivors.
What could go wrong
This is a very small pilot study with only 12 participants, so results may not apply to everyone. The program is delivered via Zoom, which may not suit all older adults.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Jun 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female, aged ≥ 60 years at the start of study * Planning to initiate AIs * Diagnosed stages I-III Breast Cancer * R+ tumor (at least 5% of cells) * Completed surgery, radiation and/or chemotherapy * Independent ambulatory (verified by treating clinician/staff) * Physician approval to start an exercise program * Must report insufficient physical activity (\<150 min. of physical activity per week) * Able to complete surveys and forms/ understand English * Agree to random assignment to exercise or control group * Can commit to 8 weeks, bi-weekly classes offered by Zoom video * Must have internet access and/or data plan by which to participate in Zoom video sessions * Minimum cognitive impairment (verified by cognitive screening questions administered by phone or in-person interview) Exclusion Criteria: * Already taking Aromatase Inhibitors (AIs) (may participate if 24 weeks or less after initiating) * Presence of metastatic cancer or concurrent malignancy requiring treatment * Recent history (past 6 months) of stroke/ Myocardial Infarction (MI), atrial fibrillation or class 3, 4 heart failure * Recent joint surgery or conditions limiting PA

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Conditions

The condition(s) this trial relates to.

breast cancer female breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer female

Contacts and locations

Locations

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

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