BREAST CANCER FEMALE

This study tests whether combining two drugs—elacestrant and trastuzumab deruxtecan—can shrink tumors in people with a certain type of advanced breast cancer (HR+, HER2-low or ultra-low) that has stopped responding to standard hormone therapy and CDK4/6 inhibitors. About 65 parti…

This study is for women aged 65 and older with a common type of early-stage breast cancer (ER-positive, HER2-negative, up to 5 cm) who are not having surgery. They will receive 5 sessions of a precise radiation treatment called SABR. The goal is to see if this approach controls t…

This study looks at whether exercise and a healthy diet can reduce the risk of heart problems and diabetes in women who have had breast cancer. About 45 postmenopausal survivors will be placed into one of three groups: exercise only, exercise plus diet counseling, or a stretching…

This study is testing whether a breast MRI before surgery can identify women with early breast cancer who have a very low risk of the cancer coming back, allowing them to skip radiotherapy after surgery. About 1,400 women aged 50 and older with certain types of breast cancer will…

This study looks at the safety of a new type of tissue support (called SC DERM® Recon) used in breast reconstruction surgery after mastectomy for breast cancer. Researchers will compare it to other similar products. About 120 women will take part, and they will be followed for 12…

This study tests whether high-intensity focused ultrasound (HIFU) can destroy breast tumors without surgery. About 15 women with small, early-stage breast cancers will receive HIFU before their planned surgery. Researchers will check if the ultrasound completely kills the invasiv…

This study is gathering images from up to 800 women with suspicious breast findings to see if a new 3D automated ultrasound system (ATUSA) can accurately detect cancer. Participants will have their standard imaging and biopsy results compared with the ATUSA scans. The goal is to …

This study is checking if a new blood test, called Oncoliq, can find breast cancer early. The test looks for tiny molecules in the blood that tumors release. Researchers will compare blood samples from 300 women with and without breast cancer to see if the test works well. If suc…

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography) every two years to the usual yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women will take part. The goal is to improve det…

This study trains Nigerian radiologists to perform ultrasound-guided breast biopsies using portable tablet devices. The goal is to make breast cancer diagnosis more accessible in areas with limited resources. About 900 women with suspicious breast lumps will take part to help eva…

This study looks at how exercise might lower breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood and breast tissue in 46 women who either join an exercise program or stay on a waitlist. The goal is to find out if exercise can reduce can…

This study tests a metacognitive strategy training program for breast cancer survivors who have trouble with memory, focus, and daily tasks after treatment. About 50 participants will learn practical thinking strategies to improve their activity performance and quality of life. T…

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer complete their full chemotherapy schedule. Participants will be assigned to either the exercise program or a health education group. The goal is to s…

This study tests a non-invasive brain stimulation technique called rTMS to see if it can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women with persistent pain will receive multiple rTMS sessions. The main goal is to measure chang…

This study is testing a special radiation device called the GammaPod to give a single, high-dose boost to the tumor site after breast cancer surgery. The goal is to see if this approach can shorten the overall treatment time by 3-4 sessions and improve quality of life for women. …

This study looks at whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients in Singapore. About 100 women who have completed surgery and chemotherapy will try these approaches. The goal is…

This study tests whether giving lidocaine (a numbing medicine) through a vein during breast cancer surgery can prevent long-term pain. About 4,300 women having a mastectomy or lumpectomy will be randomly assigned to receive lidocaine or a placebo. The main goal is to see if fewer…

This study tests whether a 12-week exercise program is practical and helpful for Black women who have finished breast cancer treatment. About 75 women will take part, with some starting exercise right away and others waiting. The goal is to see if the program improves strength, m…

This study looks at whether taking creatine supplements helps breast cancer survivors get stronger and have more energy from exercise. About 60 women who finished chemotherapy in the last 6 months will do virtual exercise sessions. Some will take creatine, some won't, and researc…

This study looks at two different exercise programs to see which one helps women gain muscle mass after finishing breast cancer treatment. Researchers will track changes in muscle and fat, as well as how well participants stick with the program. The goal is to find the best way t…

This study looks at whether eating only during an 8-hour window each day (time-restricted eating) can help women with breast cancer have fewer side effects and better quality of life during chemotherapy. Some participants will also follow a Mediterranean diet. The study involves …

This study tests whether a guided digital self-hypnosis program can reduce hot flashes in women being treated for breast cancer with hormone therapy. About 76 participants will use the app daily for three weeks. The goal is to ease this common side effect, improve quality of life…

This study looks at how antibiotics change the bacteria in the gut and breast after mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a strong genetic risk will provide tissue and…

This study is for women aged 65 and older with early-stage, hormone-sensitive breast cancer. It tests whether taking hormone therapy for 3 months before surgery helps patients and doctors make better decisions about whether radiation is needed afterward. Half the participants wil…

This study looks at how a temporary drop in oxygen during breast cancer surgery may change the tumor's genes and proteins. Researchers will take tissue samples from 500 women at different points during their operation. The goal is to understand these changes, not to test a new tr…

This study takes tumor samples from women with aggressive breast cancers (triple-negative or luminal B) and transplants them into mice to grow. The goal is to better understand how tumors change, resist treatment, and spread. About 85 participants will provide samples, but this r…

This study collects mammogram images and survey answers from 20,000 adults to train artificial intelligence (AI) models. The goal is to help doctors read mammograms more accurately for different groups of people and types of breast cancer. Participants must be 18 or older, have h…

This study looks at why some breast cancer patients have trouble with memory and focus after chemotherapy. Researchers will compare 150 women with breast cancer to healthy women of the same age. Participants will take thinking tests and give blood samples over five months, and so…

This study looks at whether a blood test that measures circulating tumor DNA (ctDNA) can help predict how well breast cancer responds to chemotherapy before surgery. Researchers will take blood samples from 125 women with stage II or III breast cancer before, during, and after tr…

This study follows 310 women who had breast cancer surgery to see how access to extra supportive services (like counseling or nutrition advice) affects their quality of life. Participants will fill out questionnaires about their physical, emotional, and social well-being over tim…