BREAST CANCER FEMALE

This phase 3 trial is for postmenopausal women with a common type of breast cancer that has a high chance of returning. Participants receive either standard hormone therapy alone or with the addition of abemaciclib, a targeted drug that blocks cancer cell growth. The goal is to s…

This study tests whether a combination of ribociclib (a targeted pill) and hormone therapy works better than standard chemotherapy for women with intermediate-risk, hormone-receptor-positive, HER2-negative early breast cancer. About 1,684 women took part. The goal is to see if th…

This study tests a combination of chemotherapy (Taxotere) and a targeted drug (trastuzumab) given before surgery to shrink tumors in Nigerian women with HER2-positive breast cancer. The main goal is to see how many women have no cancer cells left in the breast or lymph nodes at t…

This study looks at a new material called SC Derm, used to help rebuild the breast after mastectomy in women with breast cancer. About 120 women will receive either SC Derm or another standard material. The goal is to see if SC Derm leads to fewer complications and better cosmeti…

This study looks at women with a high-risk type of breast cancer (HR+/HER2-) who have already completed initial treatments like surgery or chemo. The goal is to see if adding the drug abemaciclib to standard hormone therapy helps keep the cancer from returning better than hormone…

This study looks at whether women with triple-negative or HER2-positive breast cancer can safely avoid sentinel lymph node biopsy if their tumor disappears completely after chemotherapy. About 350 women from Europe will join, and doctors will check if cancer returns in the armpit…

This study tests if a robot-assisted surgical system (da Vinci SP) is as safe and effective as traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. About 204 participants will be randomly assigned to one of the two procedures. The goal i…

This study tests whether adding the targeted drug pyrotinib to standard chemotherapy and trastuzumab before surgery can completely eliminate tumors in women with HER2-positive early breast cancer. About 53 women with stage II to III breast cancer will receive the combination for …

This study tests a combination of two drugs, sacituzumab govitecan and trastuzumab, in 28 people with HER2+ breast cancer that has spread and has been previously treated. The goal is to see if this combination can shrink tumors or slow cancer growth. Participants receive both dru…

This study looks at whether contrast-enhanced mammography (CEM) can find breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women aged 30-85 will get both types of mammograms to compare detection rates and false alarms…

This study is testing a new way to screen for breast cancer using a laser analysis of a blood sample (liquid biopsy). Researchers will compare results from 1,100 women—some with early-stage breast cancer and some without—to see if the laser test can accurately detect cancer. If s…

This study tests two different vaccines in people who had HER-2 positive breast cancer and still had cancer cells after initial treatment. The goal is to see if the vaccines are safe and can help prevent the cancer from coming back. Participants receive a series of vaccine shots …

This study tests an internet-based program called SHINE to help breast cancer survivors manage sexual concerns after treatment. About 340 women who finished primary cancer treatment at least 12 weeks ago will take part. Participants receive online education and tools over 12 week…

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The program is designed with community input t…

This study looks at why some women disagree with their personalized breast cancer risk estimate given during mammography screening. Researchers will ask 726 women aged 39-74 about their risk, offer them extra screening information, and check their future screening plans. The goal…

This study looks at how breast cancer itself, before any treatment, might affect a woman's ability to preserve her eggs for future pregnancy. Researchers will compare egg quality and ovarian function between 100 women with breast cancer and healthy egg donors. The goal is to unde…

This study tests two approaches to encourage women in rural Ghana to get screened for breast cancer. One approach offers breast cancer screening alongside tests for diabetes and high blood pressure. The other involves sessions with men to change attitudes and increase support for…

This study looks at whether giving older women (65+) with early-stage, hormone-sensitive breast cancer a 3-month course of hormone pills before surgery helps them and their doctors decide if radiation is needed afterward. About 84 women will take the pills and report how they fee…

This study follows 100 women with breast or gynecological cancer to see if what they eat in the month before starting chemotherapy is linked to levels of a protein called hepcidin. Researchers will also check if hepcidin levels relate to how much of the planned chemo dose patient…

This study follows 94 women aged 50 and older with early-stage, low-risk breast cancer who received a single dose of radiation during surgery (IORT). Researchers track cancer recurrence, side effects, and quality of life over time. The goal is to gather real-world data on how wel…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …