Gene test may help breast cancer patients avoid major surgery
NCT ID NCT05666258
First seen Jun 16, 2026 · Last updated Jun 23, 2026 · Updated 2 times
Summary
This study tested whether a gene test called MammaPrint can help doctors decide which breast cancer patients need chemotherapy before surgery. The goal is to shrink tumors enough so that patients can have less invasive surgery, like a lumpectomy instead of a mastectomy. The study included 22 women with a specific type of breast cancer (HR+, HER2-).
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Universitair Ziekenhuis Brussel
Jette, Brussels Capital, 1090, Belgium
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MammaPrint gene expression profiling test
What this could lead to
If successful, this approach could help some breast cancer patients avoid mastectomy or full lymph node removal by identifying who benefits from chemo before surgery.
What could go wrong
This is a small, completed study with only 22 participants, so results may not apply to all patients. The gene test may not accurately predict who needs chemo, and some patients might still require more extensive surgery.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.