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Targeted radiation may extend life quality in breast cancer that has spread

NCT ID NCT04495309

Disease control Sponsor: University Hospital Schleswig-Holstein Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding focused radiation to the cancer spots (metastases) can help people with breast cancer that has spread to a few places (up to 5 spots). 87 participants received either standard drug therapy alone or standard therapy plus radiation. The goal was to see if the combination could delay cancer growth and improve quality of life. This approach aims to control the disease, not cure it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

87 people

The number who actually took part.

Started

Mar 2021

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Metastasized breast cancer - up to 5 clinically manifest (new, progressive, persistent) metastases (a lymph node metastasis and a circumscribed local recurrence are each considered as one metastasis, i.e. also locoregional recurrent breast carcinomas with additional hematogenic metastasis possible) * maximum of 3 cerebral metastases known * indication for palliative drug therapy (endocrine therapy and/or chemotherapy and/or treatment with other substances) given according to guidelines (1st-line or further therapy lines, a special regime is not specified) * Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2 * local radiation of all metastases possible * presentation of a written declaration of consent * patient ≥ 18 years Exclusion Criteria: * Previous radiotherapy, if this interferes with treatment within the scope of the study * symptomatic metastases requiring local therapy of all metastases (e.g. pain radiation), a radiation indication (or other local therapy) for individual metastases is not a criterion for exclusion * known central nervous system (CNS) metastasis without extracerebral metastasis (in these cases, immediate local therapy is mandatory) * more than three known CNS metastases (no indication for purely local therapy of only the metastases, primary whole brain radiation is indicated) * multifocal metastasis in one organ with impossibility to comply with the dose constraints for this organ (e.g., no indication for local therapy of only the metastases, primary whole brain radiation is indicated) (e.g. in the liver) * exclusively regional lymph node metastasis without haematogenic metastases (in these cases local therapy is clearly indicated according to guidelines) * relevant comorbidity, if this results in restrictions for further therapy * Incapacity to contract or lack of informed consent * Pregnancy and lactation

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic breast cancer

Contacts and locations

Locations

  • Christian-Albrechts-University Kiel, University Medical Center Schleswig-Holstein, Campus Kiel

    Kiel, Schleswig-Holstein, 24105, Germany

  • Evangelische Kliniken Gelsenkirchen Klinik für Strahlentherapie

    Gelsenkirchen, North Rhine-Westphalia, 45879, Germany

  • GSR Hameln im Sana Klinikum Hameln-Pyrmont

    Hamelin, Lower Saxony, 31785, Germany

  • Gemeinschaftspraxis für Strahlentherapie

    Hildesheim, Lower Saxony, 31135, Germany

  • Heinrich-Braun-Klinikum Zwickau gGmbH Klinik für Strahlentherapie und Radioonkologie

    Zwickau, Saxony, 08060, Germany

  • Johanniter-Krankenhaus Genthin-Stendal

    Stendal, 39576, Germany

  • Klinikum Frankfurt (Oder) GmbH Klinik für Strahlentherapie/Radioonkologie

    Frankfurt (Oder), Brandenburg, 15236, Germany

  • MVZ WOB GmbH Strahlentherapie

    Wolfsburg, Lower Saxony, 38440, Germany

  • Praxis für Strahlentherapie und Radioonkologie am Krankenhaus Weilheim

    Weilheim, Bavaria, 82362, Germany

  • Strahlentherapie Bocholt Gemeinschaftspraxis und Belegabteilung am St.-Agnes-Hospital

    Bocholt, North Rhine-Westphalia, 46397, Germany

  • Städtisches Klinikum Dresden, Strahlentherapie

    Dresden, Saxony, 01067, Germany

  • Universitätsklinikum Marburg Klinik für Strahlentherapie und Radioonkologie

    Marburg, Hesse, 35033, Germany

  • Universitätsmedizin Mannheim Klinik für Strahlentherapie und Radioonkologie

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Xcare Praxis für Strahlentherapie Saarlouis am Marienkrankenhaus

    Saarlouis, Saarland, 66740, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.