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Nerve block before mastectomy: can it cut opioid use and lasting pain?

NCT ID NCT07817797

Symptom relief Sponsor: University Tunis El Manar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing whether an ultrasound-guided paravertebral nerve block, given before general anesthesia, reduces the amount of opioid painkiller needed during a mastectomy. The study enrolls 40 women with breast cancer who are scheduled for unilateral mastectomy, with or without lymph node removal. Half receive the nerve block plus standard multimodal analgesia, and half receive multimodal analgesia alone. The team measures opioid use during surgery and tracks acute pain and chronic pain three months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an ultrasound-guided paravertebral nerve block given before general anesthesia
What this could lead to
If it works, this could give women having a mastectomy a way to need fewer opioids during surgery and face less pain in the months afterward.
What could go wrong
This is a small study of 40 women at one hospital, so its results may not hold for everyone. A paravertebral block can fail or cause side effects, and some women may still need opioids for pain control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jan 2018

Finished

Dec 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged more than 18 years. * ASA physical status I or II. * Breast cancer. * Scheduled for unilateral mastectomy with or without axillary lymph node --dissection. * Written informed consent. Exclusion Criteria: * Allergy to local anesthetics and/or level 1 or 2 analgesics. * Contraindication to paravertebral block, including sepsis or coagulation -disorders. * Use of antiarrhythmic drugs. * Long-term analgesic treatment. * Preoperative chemotherapy and/or radiotherapy. * Metastatic or complicated breast cancer. * Thoracic spinal malformations or neuropathy. * History of peptic ulcer disease.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer

Contacts and locations

Locations

  • Centre de Maternité et de Néonatologie de Tunis (CMNT)

    Tunis, Tunisia

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