8-Hour eating window may cut cancer risk, early study hints
NCT ID NCT05038137
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether time-restricted feeding (eating only during an 8-hour window each day) could change certain blood markers linked to breast cancer risk. Twenty-nine postmenopausal women with prediabetes were randomly assigned to either the 8-hour eating schedule or a normal 12+ hour eating schedule for 3.5 months. The main goal was to see if the eating pattern was feasible and if it affected levels of AGEs and sRAGE, substances in the blood that may influence cancer risk.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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29 people
The number who actually took part.
- Started
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May 2022
- Finished
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Apr 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 67 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 40 and ≤ 67; * Postmenopausal women (no menstrual periods in the preceding 12 or more months) with pre-diabetes (A1C 5.7-6.4% and/or fasting glucose 100-125 mg/dL). A1c lab and/or fasting glucose criteria will need to be met within 12 months of signing consent form, can be obtained from prior lab result or study prescreening testing; * Own a smart phone with internet connection and capable of receiving and sending text messages and taking photographs; Exclusion Criteria: * Tobacco use (current or within last 2 years); * Active malignancy or history of cancer; * History of known liver disease (by serology: aspartate aminotransferase or alanine aminotransferase ≥ 3 times above upper limit of normal determined by lab review, imaging or biopsy: determined by patient history); * History of kidney disease (patient history and/or estimated glomerular filtration rate less than 45 mL/min/1.73m²); * History of diabetes mellitus: * History of cardiovascular disease (MI, CHF); * Current prescription medication use for diabetes; * Medication affecting glucose metabolism or appetite or immunosuppression; * Dietary restrictions: currently following vegetarian or vegan dietary pattern; * Currently following intermittent fasting or time restricted feeding pattern or use in the last 3 months; * Night shift worker (work schedule does not involve any period of work from 10 PM to 5 AM either on a regular or rotating basis); * History of weight loss \>5% in the last 3 months; * History of weight loss surgery. * BMI≥40 kg/m² exclusion; * After informed consent and run in period: Insufficient documented food photography/annotated entries (does not log at least two entries a day for 10 of 14 days) during run in period will be excluded from randomization in to the intervention period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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