New combo targets Hard-to-Treat breast cancer in early trial
NCT ID NCT04253561
First seen Mar 24, 2026 · Last updated May 23, 2026 · Updated 6 times
Summary
This early-phase study tested a new drug combination for people with advanced HER2-positive breast cancer that has a specific gene change (PIK3CA mutation). The goal was to find a safe dose of the study drug ipatasertib when given with two standard drugs (pertuzumab and trastuzumab). Only 17 people took part, and the focus was on safety and side effects, not on curing the disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centro Integral Oncológico Clara Campal (CIOCC)
Madrid, Madrid, Spain
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Comp. Hosp.Univ. Santiago (Chus)
Santiago de Compostela, La Coruña, Spain
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Fundación Instituto Valenciano de Oncología
Valencia, Valencia, Spain
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H.Univ. Arnau de Vilanova de Lleida
Lleida, Lleida, Spain
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Hospital Universitario Doce de Octubre
Madrid, Madrid, Spain
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Hospital Universitario Virgen del Rocio
Seville, Sevilla, Spain
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Hospital Universitario del Vall d' Hebron
Barcelona, Barcelona, Spain
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Hospital Virgen de Macarena
Seville, Sevilla, Spain
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ICO Badalona
Badalona, Barcelona, Spain
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MD Anderson
Madrid, Madrid, Spain
Conditions
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