Which nerve block eases breast surgery pain best?
NCT ID NCT07041762
First seen Aug 18, 2026 · Last updated Aug 26, 2026 · Updated 4 times
Summary
This trial compares two ultrasound-guided nerve block techniques for pain relief after breast cancer surgery. It aims to see which method better controls pain, reduces opioid use, and improves recovery in women undergoing a mastectomy. Participants will receive one of the two blocks before surgery, and their pain and opioid needs will be tracked for 24 hours afterward.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Two ultrasound-guided nerve block techniques: rhomboid intercostal with sub-serratus plane block versus erector spinae plane block, using bupivacaine.
- What this could lead to
- If one nerve block proves better, it could become the preferred method for managing pain after breast cancer surgery, reducing opioid use and speeding recovery.
- What could go wrong
- This is a small, early-stage comparison, so results may not apply to all patients. Nerve blocks carry risks like infection, bleeding, or incomplete pain relief.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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80 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female breast cancer patients undergoing Modified Radical Mastectomy (MRM) ASA physical status II or III Age between 18 and 65 years Body Mass Index (BMI) \> 20 kg/m² and \< 35 kg/m² Exclusion Criteria: * Patient refusal ASA physical status IV Age \<18 years or \>65 years BMI \< 20 kg/m² or \> 35 kg/m² Known allergy or contraindication to local anesthetics or opioids History of psychological disorders or chronic pain Contraindications to regional anesthesia (e.g., coagulopathy, local infection, peripheral neuropathy) Severe respiratory, cardiac, hepatic, or renal disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Cancer Institute - Cairo University
Cairo, Egypt
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Other studies related to the condition(s) this trial covers.