Arterial disorder

Researchers test whether adults with chronic coronary artery disease can safely go home within 6 hours after a successful elective transradial heart stent procedure, compared with the usual overnight hospital stay. The trial enrolls 58 adults at a Brazilian public hospital and fo…

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

This Phase 3 trial tests whether a tenecteplase biosimilar called GNR-060 works as well as the reference drug Metalyse in people having a severe heart attack known as ST elevation myocardial infarction. Participants receive a single weight-based intravenous dose of one drug or th…

Researchers are testing whether adding an experimental drug called AJU-C52 helps lower blood pressure in adults with essential hypertension that is not well controlled on a standard treatment called C52R1L. The trial enrolls about 193 adults with high blood pressure despite medic…

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This study looks at how well minimally invasive procedures (like balloons and stents) work for people with severe blockages in the leg arteries. It will track 1000 patients to see if these treatments restore blood flow and keep arteries open over time. The goal is to find the bes…

Researchers are testing a 12-week low-fat, plant-based diet program delivered in a doctor's office. The program encourages whole grains, vegetables, legumes, and fruits, with no animal products or added oils, and no calorie counting. The study measures changes in weight, blood pr…

Researchers at Marmara University are testing whether a 12-week telenursing program helps people with hypertension feel more confident about managing their condition and improves their quality of life. The program combines face-to-face education, home blood pressure monitoring tr…

Researchers compare two ways of managing blood flow during carotid endarterectomy, a surgery that clears plaque from the neck artery to prevent stroke. One group receives a shunt routinely, while the other gets a shunt only when a pressure measurement suggests it is needed. The t…

Researchers test whether a connected pillbox with pre-filled trays and automated text or phone reminders helps people with type 2 diabetes, high blood pressure, or high cholesterol take their medications as prescribed. The study enrolls about 50 adults who have struggled to stay …

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

Researchers are testing whether intensive blood pressure lowering slows heart and valve damage in people with asymptomatic moderate to severe aortic valve stenosis. The trial enrolls 60 adults with high blood pressure and a narrowed aortic valve but no symptoms. Half receive stan…

Researchers are comparing two ways to treat blocked leg arteries: doing the procedure as an outpatient visit versus keeping patients overnight in the hospital. The study enrolls 160 adults with peripheral arterial disease who need a minimally invasive procedure to open their arte…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

This study tested whether a half-dose blood thinner (ticagrelor) taken alone after heart stent placement works as well as the standard two-drug therapy in East-Asian patients with chronic coronary syndrome. Sixty participants were randomly assigned to one of three treatment group…

People with peripheral arterial disease often need minimally invasive procedures that thread catheters through the femoral artery in the groin. Afterward, doctors use closure devices to stop bleeding at the puncture site. This trial randomly assigns participants to one of two dev…

Pre-eclampsia is a serious pregnancy complication that can harm both mother and baby, and the only cure is delivering the baby. Researchers are testing whether citrulline, a natural amino acid, can safely prolong pregnancy for women hospitalized with pre-eclampsia before 36 weeks…

Researchers are testing a stent-like device called the DynamX Drug-Eluting Coronary Bioadaptor System in people with complex coronary artery blockages, including long lesions, chronic total occlusions, and blockages at artery branches. The study enrolls about 55 adults and measur…

This study looks at whether alirocumab, a drug that lowers cholesterol, can reduce the risk of heart attack, stroke, or death in people who have hardened arteries but have never had a heart attack or stroke before. Researchers will analyze data from routine medical care to compar…

Researchers are studying the long-term safety and effectiveness of the Barostim Neo System in people with uncontrolled high blood pressure who already received the implant. Participants continue their usual blood pressure medications while the device stimulates nerves in the neck…

This study tested whether giving the cholesterol-lowering drug evolocumab within 24 hours after clot-busting treatment (thrombolysis) can prevent early neurological decline in people with acute ischemic stroke. 132 participants were randomly assigned to receive evolocumab plus st…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This trial tests whether giving older adults with hypertension a personalized 'Heart Age' report during a routine doctor's visit can boost their awareness of cardiovascular risk and encourage healthier habits. Participants receive a one-page report based on their annual health ch…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This study tests whether a nurse-led smoking cessation program with free drugs and follow-up at healthy life centers helps heart patients quit smoking better than just giving them written information. About 221 daily smokers hospitalized for a heart event will be split into two g…

This trial is evaluating a new device called the Bifurcated Multilayer Flow Modulator (BMFM) for treating abdominal aortic aneurysms that involve the iliac arteries. The device is designed to be implanted inside the blood vessel to help stabilize the aneurysm and prevent it from …

This trial tests an implant called OTX-TIC, which is placed inside the eye and slowly releases travoprost, a drug that lowers eye pressure. The study includes adults with open-angle glaucoma or ocular hypertension, a condition of high pressure in the eye. Participants receive eit…

This study tests whether a gamification program, along with support from a partner and updates to their doctor, can help 84 adults with high blood pressure and high cholesterol take their medications more consistently. Participants who have struggled with adherence will either re…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This study tests whether collecting and re-infusing unwashed shed blood during off-pump coronary artery bypass surgery can reduce the need for donor blood transfusions and lower complications. Fifty adults undergoing this surgery will have their shed blood returned via a special …

This study looks at two ways to perform coronary artery bypass grafting, a surgery that reroutes blood around blocked heart arteries. One method uses a single chest artery for the graft, while the other uses both chest arteries. Researchers will compare long-term survival, stroke…

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This trial tests a behavioral program for African American women with high blood pressure. The program combines standard education on diet, exercise, and medication with a social component: sharing blood pressure management information with peers. Researchers will measure blood p…

This trial tests three medications, phenylephrine, norepinephrine, and ephedrine, to see which one best manages low blood pressure that can occur after spinal anesthesia in women with preeclampsia having a cesarean delivery. Researchers will give each participant one of the three…

This clinical trial is testing a new medication called HGP2102 for people with essential hypertension, or high blood pressure. The study compares HGP2102 to a control drug to see how well it lowers blood pressure over a full 24-hour period. Participants are adults with high blood…

This trial tests whether taking vitamin K2 (with vitamin D) every day can slow the progression of calcium buildup in the coronary arteries—a key risk factor for heart attacks. It enrolls 400 men and women with severe coronary calcification, who are randomly assigned to receive th…

This trial compares two guiding catheters—GUIDEX and Launcher—used during a procedure to open narrowed heart arteries (percutaneous coronary intervention, or PCI). About 150 adults with coronary artery disease will be randomly assigned to receive one of the two catheters. The goa…

This trial tests whether using detailed CT images of the heart's arteries to plan invasive procedures can reduce radiation exposure, procedure time, contrast use, and tools needed. Adults with stable angina and significant blockages are randomly assigned to receive either standar…

This trial asks whether apixaban or rivaroxaban, two standard blood thinners, causes fewer bleeding problems during the first three months of treatment for acute pulmonary embolism (blood clots in the lungs). About 540 adults with confirmed pulmonary embolism will be randomly ass…

This study tested whether taking metformin daily for six months can improve how far people with peripheral artery disease can walk in six minutes. 203 participants were randomly assigned to receive metformin or a placebo. The goal was to see if this common diabetes drug could eas…

This study tests whether time-restricted eating—eating only between 11 am and 7 pm—can safely and effectively boost the benefits of standard cardiac rehabilitation for people with coronary artery disease. About 45 participants will be randomly assigned to either standard rehab al…

This trial tests whether hydroxychloroquine, an anti-inflammatory drug, can reduce cardiovascular disease risk in people with chronic kidney disease (CKD). Participants with moderate-to-severe CKD will receive either hydroxychloroquine or a placebo for 18 months. Researchers will…

This trial compares two types of contrast agents used during optical coherence tomography (OCT), a test that takes detailed pictures of the heart's arteries. The study will see if one agent uses less contrast, produces clearer images, and causes fewer heart rhythm changes than th…

This study tests whether a short digital education program can improve self-care and health literacy in people with high blood pressure. 166 adults aged 50 and older will attend two 15-20 minute sessions covering healthy habits and digital health tools. Researchers will compare t…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This trial compares two types of drug-eluting stents—tiny mesh tubes that prop open arteries—in people with completely blocked coronary arteries. One stent uses a coating that dissolves over time (bioresorbable polymer) to release the drug sirolimus, while the other has a permane…

This trial tests whether a structured support program can help people with coronary artery disease maintain regular exercise after completing cardiac rehabilitation. Participants receive group counseling calls, personal phone check-ins, and introductions to community exercise pro…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during e…

This study tested whether a drug called GM-CSF can improve symptoms and blood flow in people with peripheral artery disease (PAD), a condition where plaque narrows leg arteries, causing pain and limiting walking. 151 participants received either GM-CSF or a placebo for two 3-week…

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This trial tests an automated system that monitors blood pressure and delivers medications to keep it stable during spinal anesthesia for cesarean sections. The system aims to prevent low blood pressure, which can cause side effects for both mother and baby. The study includes wo…

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This trial tests whether specially made cookies containing pumpkin seeds and walnuts can improve cholesterol levels in adults with atherosclerosis. For six weeks, one group eats a daily cookie while the other receives usual care alone. Researchers measure changes in LDL and HDL c…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial investigates whether a 10-week Zumba-based exercise program can help lower blood pressure in adults with hypertension. Participants will either join three 50-minute Zumba sessions per week or maintain their usual lifestyle. Researchers will also measure changes in body…

This phase 2 trial tests whether vericiguat, a drug already used for heart failure, can improve blood vessel function in people with vasospastic angina—a type of chest pain caused by spasms in the heart's small arteries, not by blockages. About 57 adults with frequent angina symp…

This study looked at whether combining two types of strength training (dynamic and isometric) can lower blood pressure more than doing just one type. Researchers studied 60 middle-aged adults with high blood pressure who were already on medication. Participants did different exer…

This trial tests whether a special compression device called NewMan can reduce bleeding and bruising after a shoulder artery procedure compared to a standard pressure bandage. The study involves 229 adults with blocked leg arteries who need a catheter inserted through the arm. Do…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This pilot study explores whether an eight-week mindfulness course or a short guided forest bathing program can lower stress and blood pressure in women over 60 who are already taking medication for hypertension. Sixty women are split into three groups: one learns mindfulness, on…

This study is testing a special balloon catheter coated with the drug paclitaxel to treat blocked arteries in the legs, a condition called peripheral artery disease. The balloon is inflated inside the artery to open it up, and the drug helps prevent the artery from narrowing agai…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in leg arteries, a condition called peripheral artery disease. About 75 adults with moderate to severe symptoms will receive the treatment. The goal is to see if the device safely …

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This trial tests two techniques for treating severely calcified coronary arteries before placing a stent. One uses a super high-pressure balloon to crack the calcium; the other uses intravascular lithotripsy, which sends shockwaves through the artery wall. The study includes 80 a…

This trial evaluates a device called the TORUS Stent Graft, a mesh tube placed inside the leg artery to keep it open in people with peripheral artery disease (PAD). The study includes about 188 adults with blockages in the thigh or behind-the-knee arteries. The goal is to see if …

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This trial is testing a new stent called Renzan to treat blockages in the leg arteries (superficial femoral or popliteal arteries). The study includes about 135 people with moderate to severe peripheral artery disease. Researchers want to see if the stent is safe and effective at…

This pilot study tests whether the DASH diet, lifestyle advice, or a combination of both can lower blood pressure in adults with prehypertension—a condition where blood pressure is higher than normal but not yet in the high blood pressure range. Researchers randomly assigned 32 p…

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take on…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This trial investigates whether a daily dose of olive leaf extract (atherolive) can help control blood pressure and improve cholesterol levels in adults with hypertension. Participants are randomly assigned to receive either the extract or a placebo for three months. The study ai…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This study tests whether having a pharmacist call both patients with heart disease and their doctors can increase the use of high-intensity statins—powerful cholesterol-lowering drugs that prevent future heart problems. The trial includes adults aged 18 to 75 with atherosclerotic…

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study tests whether a 10-week program of balance and multicomponent exercises can improve muscle strength, flexibility, balance, and endurance in adults over 50 who have high blood pressure. Participants will do exercises like sit-to-stand, bicep curls, and walking tests. Th…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study followed 48 people who received the Nellix system, a device that seals abdominal aortic aneurysms from the inside using stents and polymer-filled bags. Researchers tracked how well the device worked right after the procedure and for up to 5 years. The goal was to see i…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meani…

This study tested a device called the PQ Bypass System in 78 people with severe peripheral artery disease (blocked leg arteries). The device is designed to create a bypass inside the artery using small tubes (stent grafts) placed through a needle puncture, avoiding the need for t…

This study tested whether briefly stopping blood flow to the aorta before surgery (called ischemic pre-conditioning) could reduce complications in people undergoing open repair of a thoracoabdominal aortic aneurysm. 65 patients were randomly assigned to receive either the pre-con…

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday …

This study tested whether giving low-income adults with high blood pressure free fruits and vegetables for 6 months could help lower their blood pressure. 104 participants from West Dallas, Texas received the produce prescription program. Researchers measured blood pressure chang…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood…

This study looked at whether eating a plant-based diet for 12 weeks could lower blood pressure and change gut bacteria in 102 kidney transplant recipients. Participants either followed a plant-based diet or their usual diet. The goal was to see if this diet could help manage hear…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This study looked at whether a progressive resistance training program could help older adults with sarcopenia (age-related muscle loss) control their high blood pressure. 77 sedentary adults aged 60 and older participated. The goal was to see if building muscle strength could be…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested a drug called sotatercept in 173 people with severe pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work too hard. Participants received either the drug or a placebo on top of their usual treatments. The goal was to see if th…

This study tested a new device called Firesorb, a temporary scaffold that slowly releases medicine to keep heart arteries open and then dissolves over time. Researchers compared it to a standard permanent stent in 430 people with coronary artery disease. The goal was to see if th…

This study followed 650 low-risk patients with severe aortic valve narrowing who received a less invasive valve replacement called TAVI. Researchers tracked deaths, strokes, and return hospital visits for heart problems. The goal was to see how well TAVI works in everyday practic…

This study looked at whether practicing tai chi—a slow, gentle exercise with deep breathing—could lower blood pressure and improve thinking skills in older adults with high blood pressure. Nineteen participants tried a single session and then a 12-week online tai chi program. Res…

This study looked at 108 people whose heart stents had narrowed again after being placed. Doctors tested three different devices: two types of drug-coated balloons and one new stent. The goal was to see which one works best to keep the artery open and prevent future heart problem…

This study tested a new device called the Vertex Pulmonary Embolectomy System in 10 people with pulmonary embolism (blood clots in the lungs). The device is threaded through a blood vessel to remove clots and relieve strain on the right side of the heart. Researchers measured cha…

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested a device called the Nellix system to repair a bulging blood vessel (aneurysm) in the belly without open surgery. 98 people with large or growing aneurysms took part. The goal was to see if the device is safe and works well at keeping the aneurysm from bursting o…

This study looked at how well the AURYON atherectomy device works for people with peripheral artery disease (PAD), where leg arteries become blocked. The device uses a laser to vaporize plaque and restore blood flow. Researchers followed 102 patients to see if the procedure was s…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in bette…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested whether the drug rituximab, given with steroids, works better than steroids alone for people with a rare disease called microscopic polyangiitis that inflames small blood vessels. Only 8 patients took part, and the goal was to see if the combination could preven…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This pilot study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve. 24 adults with mild-to-moderate aortic stenosis were randomly assigned to take colchicine or a placebo for 6 months. The study measured changes in valve cal…

This pilot study tested a hybrid rehabilitation program for people with peripheral arterial disease (PAD), a condition that causes leg pain and limits walking. The program combines a few on-site supervised sessions with a home-based walking plan to make it easier for patients to …

This study tested whether a breathing muscle training device could improve blood flow in the hearts of people with coronary artery disease. Forty participants used the device daily for six weeks. Researchers compared high-intensity versus low-intensity training to see if it incre…

This completed trial tested whether combining a gentle brain stimulation technique called tDCS with intensive rehabilitation can improve hand function in children with hemiplegic cerebral palsy caused by perinatal stroke. 89 children participated, and the study measured changes i…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at whether a 12-week course of glecaprevir/pibrentasivir can safely cure hepatitis C in heart transplant patients who got the virus from infected donors. Fifty adults on the transplant waitlist were enrolled, and those who received a hepatitis C-positive heart w…

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This completed study tested a two-step treatment for severely calcified leg artery disease in 50 patients. First, a shockwave device cracks the hard calcium deposits, then a drug-coated stent is placed to keep the artery open. The goal was to see if this approach is safe and effe…

This study tested two different drug-coated stents (everolimus-eluting vs. sirolimus-eluting) in 1,466 people with narrowed heart arteries. It also compared taking the blood thinner clopidogrel for 6 months versus 12 months after stenting. The goal was to see which stent and whic…

This early feasibility study tested a 3D holographic guidance system to help surgeons place stent grafts during endovascular aortic repair (EVAR) for abdominal aortic aneurysms. Two patients participated, and the system was used alongside standard X-ray imaging to confirm correct…

This study looked at whether giving people home blood pressure monitors and teaching them to use online portals and texting with their doctors can help them better control their high blood pressure. Over 500 adults with uncontrolled hypertension took part for 12 months. The goal …

This completed study tested whether combining valsartan and hydrochlorothiazide works better than valsartan alone for people with hypertensive heart disease. 118 adults aged 18-70 took part over 8 weeks. Researchers measured blood pressure, heart changes on ECG, and symptoms to s…

This study compared two different artificial heart valves (Sapien and Myval) used in a procedure called TAVI to replace a narrowed aortic valve. Over 1,000 patients were randomly assigned to receive one of the two valves. The goal was to see which valve led to fewer major heart p…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This completed Phase 4 trial tested the drug inclisiran (given as a shot under the skin) against a placebo in 1770 adults with high cholesterol who were already on cholesterol-lowering therapy. The goal was to see if inclisiran helps more people reach their LDL cholesterol target…

This study tested a new device called the Hēlo PE Thrombectomy System, which is a thin tube used to remove blood clots from the lungs in people with a serious condition called pulmonary embolism. The trial included 177 participants and aimed to see if the device is safe and works…

This study tested whether quercetin, a natural compound found in fruits and vegetables, can reduce inflammation and signs of cell aging in 100 people undergoing heart bypass surgery. Participants received quercetin or a placebo before and after surgery. The goal was to see if que…

This study tested a digital quality improvement program to help doctors better manage LDL (bad) cholesterol in patients with heart disease. Over 1,400 adults with established cardiovascular disease participated. The program used smartphone tools to improve treatment and follow gu…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study tested a new device called the Wave PRO System that helps improve blood flow in people with chronic stable angina (chest pain). The device works by gently squeezing the legs to push more blood to the heart. The study included 52 adults with mild to moderate coronary ar…

This study looked at 1,500 people with severe blockages in three heart arteries. It compared a less invasive procedure using a pressure wire to guide stent placement (FFR-guided PCI) with open-heart bypass surgery (CABG). The goal was to see if the stent approach could match the …

This pilot study tested whether delivering the drug paclitaxel directly to the leg artery during angioplasty could reduce the chance of the artery narrowing again. 27 adults with leg pain from blocked arteries took part. The main goal was to see if the drug helped keep the artery…

This study tested a two-step procedure for people with severely hardened heart arteries. First, doctors used a special device to shave away hard plaque, then inflated a drug-coated balloon to open the artery. The goal was to see if this approach could safely improve blood flow an…

This study tested whether a special monitor placed in the breathing tube during heart bypass surgery could help doctors manage fluids and blood flow better. 100 adults having elective coronary bypass surgery were split into two groups: one got standard care, the other used the EC…

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or n…

This study tested whether using intravascular ultrasound (a tiny camera inside the artery) to guide stent placement in the leg is better than the usual X-ray guidance. One hundred people with blocked leg arteries were randomly assigned to one of the two methods. The goal was to s…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This study looked at how well the ELUVIA drug-coated stent works in real-world patients with blocked arteries in the thigh or knee area. A total of 291 adults received the stent and were followed for two years. The main goal was to see if their quality of life and walking ability…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This study tested whether a smartphone app and home blood pressure monitor could help doctors personalize the dose of the blood pressure drug Zestril for each patient without needing in-person visits. Twenty adults with uncomplicated high blood pressure participated. The goal was…

This completed study gave 580 Native American adults and children in Osage Nation weekly boxes of fresh fruits and vegetables along with healthy recipes and cooking classes. The goal was to see if this program could improve diet, lower blood pressure, and reduce health risks like…

This study tested whether using a balloon-guided catheter helps doctors remove blood clots more effectively in people having a stroke. 110 adults with acute ischemic stroke were randomly assigned to receive clot removal with either a balloon-guided or standard catheter. The main …

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This completed study tested whether community health workers (CHWs) and home blood pressure monitoring could help adults in rural South Africa control their high blood pressure. Over 770 participants were assigned to different levels of CHW support. The goal was to see if this ap…

This study looked at 50 people who had a procedure to clear hardened blockages in their leg arteries using a special device (Jetstream) followed by a drug-coated balloon (Ranger). Researchers checked how many patients avoided needing another procedure on the same spot after 3 yea…

This study tested a new drug-coated stent called EvroSure in 888 people with blocked heart arteries. The stent releases medicine to keep the artery open and prevent future blockages. Researchers tracked major heart events like heart attacks or the need for repeat procedures at 30…

This completed pilot study tested whether a very low-carbohydrate diet could lower blood pressure in 64 lower-income African American adults with high blood pressure. Participants followed either a low-carb or standard low-fat diet for 10 months. Researchers measured changes in b…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This study tested a low-cost tool to help health workers in Mozambique better diagnose and manage high blood pressure in people with HIV. The tool uses cycles of evaluation and improvement to streamline care. Researchers worked with 18 health facilities to see if this approach co…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study tested a personalized education program called 'Mi Propio Camino' (My Own Way) to help Hispanic adults with uncontrolled high blood pressure stick to their medication. Over 500 participants received either the tailored program or standard care. The goal was to see if p…

This study tested the drug upadacitinib (RINVOQ) in 429 people with giant cell arteritis, a condition causing inflamed blood vessels. Participants took the drug or a placebo along with steroids. The goal was to see if upadacitinib helps achieve remission faster and with less ster…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested an experimental drug called KUS121, given as an eye injection, for people who suddenly lost vision due to a blocked artery in the eye (central retinal artery occlusion). The goal was to see if the injection could improve vision better than a sham procedure. The …

This study tested two drugs, levosimendan and dobutamine, in 52 adults undergoing heart valve replacement. The goal was to see which one better preserves right ventricular function after surgery. Patients were randomly assigned to receive one of the drugs, and their heart functio…

This study looked at 47 people with thoracoabdominal aortic aneurysms (a bulge in the main artery in the chest and belly). They received a custom-made stent graft (a fabric-covered metal tube) designed to fit their unique anatomy. The goal was to see if the aneurysm size stayed s…

This study tested a new drug called AZD0780 in 202 people with heart disease or related risks and high LDL cholesterol. Participants took either the drug or a placebo for 4 weeks, and researchers measured changes in blood pressure using a 24-hour monitor. The goal was to see if A…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested a new tool called the AngioSafe Peripheral CTO Crossing System in 79 people with blocked leg arteries (peripheral artery disease). The goal was to see if the device could safely help doctors place a guidewire through the blockage. The study measured how often th…

This study will test if the Oura Ring can identify signs of high blood pressure using a new algorithm. Researchers will compare the ring's readings to what participants report about their own blood pressure. Up to 2 million adults in the US who already use an Oura Ring will take …

Researchers are studying whether a machine-learning monitor can predict low blood pressure episodes in patients having lung surgery with one-lung ventilation. The study enrolls about 77 adults scheduled for lobectomy or pneumonectomy. During surgery, the team records standard blo…

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

Researchers at the University of Salerno are testing whether an artificial intelligence system can grade glaucoma severity from standard visual field tests as reliably as an expert ophthalmologist. The study follows about 50 adults with glaucoma or suspected glaucoma who have vis…

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

This study tests whether a software program called ElucidVivo can accurately predict blood flow blockages in the heart using images from a standard CT scan. The software analyzes plaque buildup in the coronary arteries to estimate a value called FFRct, which indicates how much a …

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, str…

This trial tests whether an AI software called AI-Gatekeeper can help doctors predict if a patient has significant coronary artery narrowing (at least 50% blockage) using only routine tests like blood work, ECG, chest X-ray, and echocardiogram. About 450 adults with chest pain an…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study compares cardiac MRI to the standard right heart catheterization for monitoring people with pulmonary arterial hypertension (PAH), a condition that strains the heart. Researchers want to see if the non-invasive MRI can reliably detect when a patient's condition is wors…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study uses a non-invasive ultrasound called transcranial Doppler (TCD) to measure blood flow in the brains of pregnant women with preeclampsia. Researchers will compare 50 women with preeclampsia to 50 healthy pregnant women to see if TCD can detect early signs of serious co…

This study tested a new rapid D-dimer blood test (LumiraDx) in 679 people with symptoms of deep vein thrombosis or pulmonary embolism. The test uses a small blood sample from a finger prick or vein to quickly measure D-dimer levels, which can help rule out dangerous blood clots. …

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This study tested whether chewing gum can help doctors diagnose giant cell arteritis (Horton's disease), a condition where blood vessels become inflamed. The idea is that chewing may trigger jaw pain in people with the disease, making it easier to spot. Researchers compared resul…

This study tested whether a special ultrasound with contrast dye can be as good as CT scans for checking aortic endoprostheses after abdominal aortic aneurysm repair. Forty patients received both an ultrasound and a CT scan after surgery. The goal was to see if ultrasound could d…

This study tested whether a simple blood test, called the aldosterone renin ratio (ARR), could help doctors find more cases of primary aldosteronism—a common but often missed cause of high blood pressure that can be cured with surgery or treated with specific medications. Researc…

This study checked how well the Withings BPM Pro 2, an automatic blood pressure cuff, measures blood pressure compared to a standard manual device. 89 adults had their blood pressure taken with both devices. The goal was to see if the Withings cuff is accurate enough for home use…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This pilot study tested whether ready-to-eat meals based on the DASH diet could help lower blood pressure and reduce heart disease risk. Twenty adults ate the prepackaged meals daily for 4 weeks while researchers monitored their blood pressure and weight. The goal was to see if a…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study looked at 1168 adults who had a heart catheterization through the wrist. It compared two methods to stop bleeding and prevent a common complication called radial artery occlusion: manual compression (hand pressure) and a pneumatic device that gradually releases pressur…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This completed clinical trial tested a procedure called ischemic postconditioning to prevent brain damage in 40 people undergoing carotid surgery for severe artery narrowing. The procedure involves briefly clamping and unclamping the carotid artery in cycles after surgery to prot…

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

Researchers are studying whether a 6-month home walking program can help people with peripheral arterial disease of the legs. Participants wear a smartwatch that counts daily steps and receive weekly phone calls from a researcher who reviews their activity and offers guidance. Th…

Researchers test whether adjusting cardiac rehabilitation to each person's muscle power profile and heart rate variability helps heart attack survivors recover better. Adults who had acute coronary syndrome in the past six months and received a stent or bypass surgery join the st…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

This study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…

People with peripheral artery disease often need procedures that thread a catheter through an artery in the groin. Doctors usually use a closure device to seal the puncture, but manual pressure may work just as well and cost less. This pilot study tests whether 30 patients can sa…

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are testing whether one 50-minute Pilates session changes blood pressure over the next 24 hours in women aged 50 and older with elevated blood pressure. Participants also complete a treadmill walking session for comparison. Each woman wears a portable blood pressure m…

This study tested a self-management app for women who had high blood pressure during pregnancy. 99 new mothers used the app to track their blood pressure, stress, and mood, or received usual care. The goal was to see if the app helps lower blood pressure and improve mental health…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This study looks at whether doing special breathing exercises before heart bypass surgery can help improve oxygen levels afterward. It will include 45 men aged 50 to 60. Some will use an incentive spirometer, some will use an inspiratory muscle trainer, and others will receive st…

This trial tests whether applying cold packs to the wrist after transradial coronary angiography reduces pain, bruising, and discomfort. About 104 adults who had this heart procedure will be randomly assigned to receive either cold packs or standard care. Researchers will measure…

This study tests whether starting gentle movement earlier than usual can reduce back pain in people who have had a procedure to open blocked heart arteries. After this procedure, patients often lie flat for hours, which can cause back pain. The study will compare early mobilisati…

This trial tests whether a single educational session about how pain works, given before coronary artery bypass surgery, can lessen chronic pain after the operation. Adults scheduled for elective bypass will either receive this pain neuroscience education plus routine care, or ro…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This trial tests whether adding a double nerve block (femoral and sciatic) before general anesthesia can reduce pain and morphine use after femoropopliteal bypass surgery in people with peripheral arterial disease. The block, using levobupivacaine and clonidine, may also widen bl…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This phase 2 trial tests whether daily injections of unacylated ghrelin, a natural hormone, can improve walking ability in people aged 55 and older with peripheral artery disease (PAD). Participants receive either the hormone or a placebo for four months. The study measures chang…

This study tested whether soaking your legs in hot water after a 30-minute walk can lower blood pressure better than exercise or heat alone. Twenty adults with slightly high blood pressure completed four different sessions: walking plus a lukewarm bath, walking plus a hot bath, h…

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This study tested whether placing elderly patients (ages 65-80) with high blood pressure in a lithotomy (legs-up) position for two minutes before anesthesia could prevent a dangerous drop in blood pressure. Sixty patients were randomly assigned to either the legs-up position or t…

This study tested whether watching a short video before coronary bypass surgery could reduce confusion (delirium) in the ICU and speed up recovery. 220 adults were randomly assigned to either watch the video or receive standard care. The video explained the surgery, ICU environme…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This pilot study tested a remotely delivered self-management program called TEAM-Red for depressed young African American women who also have risk factors for high blood pressure. 83 women participated in group video sessions over 12 weeks, with researchers tracking changes in de…

This study tested a new device called VIVHEART EasyCross™ in 20 people undergoing transcatheter aortic valve replacement (TAVR). The device uses a basket-like tip to center itself in the artery, making it easier and quicker to guide a wire through the heart valve. The goal was to…

This study looked at whether a single intravenous iron dose could improve exercise capacity in people with severe aortic stenosis and iron deficiency who were scheduled for a valve replacement. About 100 participants received either iron or a placebo. The main goal was to see if …

This completed pilot study looked at whether yoga can help African American adults with high blood pressure manage stress and remember to take their medication. Eight participants attended weekly yoga sessions for 8 weeks. Researchers measured blood pressure, stress levels, and t…

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assig…

This study tested whether avoiding morphine during heart surgery could reduce common complications like breathing problems, confusion, and gut issues. 268 adults having planned heart surgery were randomly assigned to receive either standard morphine-based anesthesia or a combinat…

This study tested whether using a vibrating device, alone or with a cold gel pack, could reduce pain and anxiety when chest tubes are removed after coronary artery bypass surgery. 93 patients were split into three groups: vibration only, vibration plus cold, or standard care. Res…

This study looked at whether motivational coaching and a home exercise program can help older adults become more active after a minimally invasive heart valve replacement called TAVR. Forty people who had the procedure took part. The goal was to see if these programs are practica…

This study tested a dynamic blended learning module for 49 people with pulmonary hypertension, a chronic disease causing symptoms like shortness of breath and fatigue. The program included face-to-face education, regular phone follow-ups, and a video from a patient who successful…

This study tested whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) in chest nerve blocks could provide better pain relief after heart surgery. Sixty adults having open-heart surgery through a chest incision received the nerve block with or without the e…

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

Researchers at Peking Union Medical College Hospital are observing 121 older adults scheduled for non-cardiac surgery under general anesthesia. They want to see whether a drop in blood pressure after eating is related to a sudden drop in blood pressure during anesthesia induction…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study compares three ways of teaching midwifery students about preeclampsia and eclampsia: a digital game, a simulation, and traditional lectures. The goal is to see which method boosts knowledge, motivation, and attitude the most. 120 fourth-year midwifery students will tak…

This study tested whether a home rehabilitation program, with daily activity tasks and heart rate monitoring sent by text or email, helps people recover better after a serious blood clot in the lung (pulmonary embolism). 32 adults who had been hospitalized for this condition took…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study looked at data from over 1,600 African Americans aged 30-55 with severe high blood pressure. Researchers examined genetic, behavioral, and social factors to find out why this group is more affected by hypertension. No new participants were enrolled; the goal was to lea…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study looks at whether early-onset preeclampsia (a serious pregnancy condition) affects the size of two brain areas in the fetus: the fornix and hippocampus. Researchers will use ultrasound to measure these areas in 84 pregnant women—half with early-onset preeclampsia and ha…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

Animal-derived heart valves replace damaged human valves, but many fail within about a decade. Researchers suspect the recipient's immune response may speed up that breakdown. This international study follows people who receive pig, cow, or horse tissue valves, using echocardiogr…

Researchers want to know whether the number of other health conditions a person has affects their quality of life after transcatheter aortic valve implantation. The study follows 150 patients aged 75 and older who receive a new aortic valve through a catheter. Before the procedur…

This study looked at 120 adults having open heart surgery to see if an AI program could correctly judge whether a pain-relieving nerve block was placed properly. Researchers compared the AI's assessment to that of a human expert and checked if better block placement led to less p…

This study examines how primary healthcare facilities in Nigeria and Sri Lanka manage high blood pressure, assessing readiness and patient outcomes. Researchers will survey facilities and patients, measure blood pressure, and interview patients, caregivers, and healthcare provide…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

Thoracic aortic aneurysms affect men more often than women, yet women face higher risks of dissection and death. Researchers are collecting aortic wall tissue from 30 adults undergoing elective aneurysm surgery to measure estrogen and testosterone receptor levels. The goal is to …

This study tested how well blood pressure cuffs work on the upper arm, forearm, thigh, and lower leg compared to a standard arterial line. Researchers measured 84 adults during planned surgery. The goal was to see if other sites give accurate readings when the upper arm can't be …

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This completed study observed over 4,500 adults with atherosclerotic cardiovascular disease who had never had a heart attack or stroke. Researchers compared those taking alirocumab (a cholesterol-lowering drug) to those not on similar therapy, using real-world data to see if the …

This study looks at two medicines, alirocumab and inclisiran, that help lower bad cholesterol (LDL-C) in people with heart disease. Researchers will use real-world data from about 124 patients to see which drug reduces cholesterol more over time. The goal is to understand how the…

This study looks at whether a new care plan can help more people with pulmonary embolism (a blood clot in the lungs) go home from the emergency room instead of being admitted to the hospital. Researchers are working with 14 hospital ERs in Michigan to track changes in how often l…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study examines whether the duration a patient spends on cardiopulmonary bypass (heart-lung machine) and with the aorta clamped during coronary artery bypass surgery is linked to how long they stay in the intensive care unit afterward. Researchers will review medical records …

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This study looked at over 3,600 adults having major surgery to find out which of two blood pressure drugs (norepinephrine or phenylephrine) works best to prevent complications like kidney injury or death. Patients received one of the two drugs during their operation. The goal was…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study is looking at whether the level of bicarbonate in the blood can help predict if a patient will die or need intensive care within 48 hours of arriving at the emergency department. Researchers will track 6,500 adults who have a blood test done as part of their regular ca…

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study follows thousands of Korean adults recently diagnosed with high blood pressure to see how often they develop silent organ damage, such as heart, kidney, or eye problems. Researchers will track these participants over time to identify factors that predict future heart a…

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers …

This study is testing whether an advanced ultrasound technique can identify which carotid artery plaques are dangerous (vulnerable) and likely to cause a stroke. Researchers will compare ultrasound images taken before surgery with the actual plaque tissue removed during the opera…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study follows 500 heart bypass patients for 10 years to see if taking two blood thinners (ticagrelor plus aspirin) for one year after surgery reduces the risk of heart attacks, strokes, or death compared to taking just one. Participants will be contacted by phone to report t…

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This trial tests whether an Apple Watch paired with a special app can accurately measure how far people with pulmonary arterial hypertension (PAH) can walk in six minutes — both in the clinic and at home. Researchers want to see if daily home-based walk tests can detect changes i…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study compares two ways to access blocked leg arteries during a procedure to restore blood flow: through the arm (brachial artery) or the groin (femoral artery). The goal is to see which approach leads to fewer complications, such as bleeding or artery damage. Participants a…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study will collect routine data from 100 adult ICU patients to build a machine learning model that predicts low blood pressure (hypotension) up to 30 minutes before it happens. The model uses non-invasive vital signs, heart rate, medication records, and fluid balance. No tre…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This study followed 72 adults with pulmonary hypertension caused by chronic lung diseases, like interstitial lung disease, who were treated with inhaled iloprost in routine care. Researchers tracked changes in their risk levels over time using a standard scoring model. The goal w…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study looks at whether special pacing signals from a pacemaker can improve heart function and lower blood pressure in people who need a pacemaker and also have high blood pressure. Researchers will measure heart pressure and volume using a thin catheter inside the heart. The…

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study tested whether a new 3D ultrasound technique can predict how well patients with pulmonary hypertension will do. Researchers followed 150 patients for six months, collecting heart images and tracking deaths and hospitalizations. The goal was to see if this non-invasive …

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This study tested a new X-ray-based imaging tool called 3DStent against the standard IVUS method to measure calcium buildup in heart arteries. Thirty adults with coronary lesions were enrolled. The goal was to see if 3DStent can accurately identify and measure calcium deposits, w…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study tested whether the Corsano CardioWatch 287-2, a smartwatch that measures blood pressure using light sensors, can accurately track blood pressure changes in people starting or adjusting their blood pressure medication. Eighty adults with uncontrolled high blood pressure…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study looked at whether applying extra breathing pressure (PEEP) during laparoscopic gallbladder surgery changes the size of the optic nerve sheath, which can indicate brain pressure. Researchers measured the nerve sheath with ultrasound at three points during surgery in 34 …

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…

This study looked at MRI scans from 72 people with two common types of small vessel disease in the brain: hypertensive arteriopathy and cerebral amyloid angiopathy. Researchers focused on tiny fluid-filled spaces in a part of the brain called the dentate nucleus. The goal was to …

This study tested a new way to predict dangerous heart rhythm problems after a common heart valve procedure called TAVR. Researchers combined ECG results with CT scan measurements and implant depth to see if they could safely identify low-risk patients. The study looked back at 2…

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at 57 kidney transplant patients to see if high blood pressure is related to having too much fluid in the body. Patients measured their blood pressure and fluid levels at home between 30 and 90 days after their transplant. The goal was to find a connection that …

This study tracked 300 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVI) to see how long they stayed in the hospital and why some stayed longer than 3 days. The goal was to find out what factors, like needing a blood transfusion or a…

This study looked at whether CT scans can help doctors choose the right size for the Perceval sutureless heart valve. The valve is used to replace a leaky aortic valve. Researchers studied 50 patients to see if CT-based sizing leads to good early results after surgery, like prope…

This study followed 326 people newly diagnosed with glaucoma or high eye pressure to see how many got worse over 2 to 4 years of standard monitoring in hospital eye clinics. Researchers measured the rate of disease progression and looked for factors that might predict worsening. …

This study looked at how the position of a patient's arms during spinal anesthesia affects pressure inside the eye. Sixty adults having hernia repair were randomly placed with arms at their sides or hands on their chest. Eye pressure was measured before and after anesthesia to se…

This study looked at how using high-flow nasal oxygen during laryngeal surgery affects the heart and blood vessels. Twenty relatively healthy adults were monitored for changes in heart function compared to standard breathing support. The goal was to understand potential risks, no…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This completed study followed over 7,200 heart patients in Tunisia to see how well they stick to their heart medications after a heart attack or procedure. Researchers simply observed and recorded data without giving any new treatment. The goal is to understand real-world medicat…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at how melatonin, a hormone known for sleep and as an antioxidant, changes during pregnancy. Researchers measured melatonin and its main byproduct in the blood of 60 women across each trimester. The goal was to gather basic information to help design larger stud…

This completed registry followed 300 patients with abdominal aortic aneurysm who were treated with the Nellix® Endovascular Sealing System across 30 international centers. The goal was to see how well the device performs in everyday medical practice, measuring safety and effectiv…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study tested whether a special 3D X-ray done in the operating room can replace standard CT scans after repairing an abdominal aortic aneurysm. 427 patients were randomly assigned to either the new 3D scan or the usual approach. The goal was to see if the new method reduces r…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study looked at how two different ways of doing resistance exercise (short vs long sets) affect the heart and blood vessels of postmenopausal women, both with and without high blood pressure. Sixty women participated, and researchers measured things like blood pressure, hear…

This study compared two non-invasive blood pressure methods—a finger sensor and a standard arm cuff—against the most accurate method, an arterial line, in 80 patients having non-cardiac surgery. The goal was to see which non-invasive method agrees more closely with the arterial l…

This study looked at data from 100 patients who had heart artery imaging and pressure measurements. Researchers developed a new computer algorithm to analyze ultrasound images of the arteries and estimate how much they block blood flow. The goal was to see if the algorithm could …

This completed registry followed over 17,000 Korean patients with coronary artery disease who received drug-eluting stents. Researchers compared several types of stents to see which ones work best and are safest over the long term in everyday medical practice. The goal is to prov…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This completed study looked at 500 adults hospitalized with dangerously high blood pressure. Researchers measured levels of the hormone aldosterone to see if it relates to how long patients stay in the hospital or if they have complications. The goal was to better understand the …

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study looked at 511 patients who had surgery to repair an abdominal aortic aneurysm (a bulging blood vessel in the belly) to find out what makes some people develop dangerously low blood pressure after the operation. The researchers reviewed medical records from 2013 to 2021…

This study looked at 70 adults having open heart surgery (aortic valve or bypass). It compared a newer, smaller heart-lung machine to the standard one. The goal was to see which method better protects the body's tissues and the brain during surgery. Results will help doctors choo…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This completed study looked at why some pregnant women in France choose not to join randomized clinical trials about pregnancy and childbirth. Researchers surveyed 526 women to find out what factors — like age, education, or how the study was explained — might influence their dec…

This study looked at 623 adults with heart failure or high blood pressure in the lungs to see how well different tests measure pressure inside the heart. Doctors used both non-invasive ultrasound (echocardiogram) and invasive catheter measurements to check for elevated filling pr…

This study looked at whether cardiac MRI can accurately measure right heart function in 112 people with pulmonary arterial hypertension. Researchers compared MRI results with data from invasive heart catheterization. The goal was to see if MRI could be used to monitor disease and…

This study reviewed medical records of 901 infants who had surgery for aortic coarctation (a narrowed aorta) before age one. Researchers wanted to find out how many later developed high blood pressure or re-narrowing of the aorta. The goal is to better understand these risks and …

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This study looked at 160 adults having planned brain surgery to see if raising blood pressure during the operation makes it harder for surgeons to stop bleeding. Doctors increased blood pressure slightly with a medicine and noted if extra steps were needed to control bleeding. Th…

This study looked at 659 patients who had surgery to fix an abdominal aortic aneurysm. Researchers compared two types of scans—CT and ultrasound—to see which one is better at finding problems like leaks or blockages after the repair. The goal was to find out if ultrasound could b…

This study tested whether a series of five one-minute educational videos, shared through community WeChat groups, could improve what people know and do about secondary hypertension. Over 1,000 adults from eight communities in suburban Beijing took part. Researchers measured chang…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new approach that filters out a protein called sFlt-1 from the blood, which may help restore normal blood vessel function. The research is a first step toward a possib…

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for a kidney disease risk gene (APOL1) could improve their care. Over 6,700 participants were randomly assigned to get their genetic results right away or later. T…

This study created a large registry of 394 patients who had surgery for an abdominal aortic aneurysm (AAA) in North Texas hospitals. The goal was to track survival, need for repeat surgery, and risk of rupture over time. By collecting this data, doctors hope to improve the qualit…

This study tested whether a 12-week mobile app program for heart rehab is practical and liked by patients with coronary heart disease. 34 adults used the app after leaving the hospital, and researchers tracked how many signed up, used the app, and stayed in the program. The goal …

This study followed 318 people with suspected coronary artery disease for about 10 years to see whether starting with a CT scan or an invasive angiogram leads to better long-term outcomes. Participants had already completed an earlier study and agreed to additional follow-up, inc…

This study looked at 55 adults having beating-heart coronary bypass surgery. Doctors compared a standard ultrasound method (TEE) with a less invasive monitor that uses the arterial line to see how well each predicted the need for extra fluids. The goal was to see if the simpler d…

This study looked at 86 people with severe aortic valve stenosis who had valve replacement surgery. Researchers used special MRI scans to measure scarring in the heart muscle before and one year after surgery. The goal was to see if the scarring improves and whether MRI could hel…

This study looked at whether a type of immune cell called T CD8 plays a role in Horton's disease, a condition that causes inflammation in blood vessels. Researchers took extra blood samples and performed standard tests on 30 newly diagnosed patients to measure these immune cells.…

This study tested whether a single session of low-volume high-intensity interval training or a combination of sauna and cold water immersion can lower blood pressure responses to physical stress. 45 healthy adults aged 18-50 participated. Researchers also looked at whether learni…

This study checked if a Samsung smartwatch can accurately measure blood pressure over a long period. Researchers compared the smartwatch's readings to a standard medical device in 42 healthy adults. The goal was to see if smartwatches could be a reliable tool for tracking blood p…

This study looked at over 1,600 people with giant cell arteritis, a condition that inflames blood vessels and raises heart risks. Researchers compared tocilizumab and methotrexate to see which better prevents heart attacks, strokes, or death. Using French health data, they analyz…

This study tests a motorized tilt table and lower-body pressure chamber designed to help military pilots train for and understand fainting and blood pooling. Forty-six pilots and cadets will be tilted and exposed to pressure changes while their heart rate, blood pressure, and bra…

This completed study tested a special guidewire with a sensor that measures electrical properties of tissues in people with peripheral artery disease. The goal was to see if the sensor could tell the difference between various tissues, like the artery wall and surrounding areas. …

This small, early study tested whether drinking beetroot juice (which is rich in natural nitrates) could improve artery stiffness and brain blood vessel function in adults aged 50 to 79. Sixteen participants were randomly given either nitrate-rich or nitrate-depleted beetroot jui…

This study tested whether automated alerts in electronic health records help doctors identify and treat patients with severe aortic stenosis or mitral regurgitation. Over 2,100 patients were included, and some doctors received alerts while others did not. The goal was to see if a…

This study looked at the bacteria living on the skin of 100 patients scheduled for a heart valve replacement procedure called TAVI. The goal was to find out which bacteria are most common in the groin area, where the doctor inserts the new valve. This information can help doctors…

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This study tested a new combination of very low-dose aspirin (20 mg twice daily) plus a blood thinner called rivaroxaban (2.5 mg twice daily) in 48 adults with chronic coronary syndromes. Researchers compared this new regimen to standard aspirin alone (75 mg once daily) and stand…

This study tested a program to help people with severe aortic stenosis get a TAVI heart valve procedure faster. The program included a website and booklet for patients, plus better coordination among hospital teams. Researchers measured whether more patients could be treated with…

This study looked at how giving IV fluids during a C-section affects heart function in women with preeclampsia. Researchers used ultrasound to measure heart output in 34 women. The goal was to better understand how to manage fluids safely in these patients.

This study looked at 53 adults having ear surgery (tympanoplasty) with their head turned to the side. Doctors used ultrasound to measure the optic nerve sheath diameter, which can indicate pressure inside the skull. The goal was to see if the sideways head position changes that p…

This study looked at how closely 227 adults with precapillary pulmonary hypertension follow their prescribed diuretic (water pill) regimen. Researchers used questionnaires and pharmacy records to measure adherence and identify reasons for missed doses. The goal is to understand n…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.