Smart system helps control blood pressure in thousands
NCT ID NCT05605418
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in better controlling hypertension.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
1,666 people
The number who actually took part.
- Started
-
Mar 2023
- Finished
-
Oct 2024
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 to 79 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria for Sites: 1. An electronic data collection system is routinely used at the clinic for hypertension management in PHC sites, and the distance between sites must be \>2km; 2. At least one drug of each of the five classes of recommended antihypertensive medications is available at the clinic: * A: Angiotensin-converting enzyme inhibitors (ACEI; e.g., captopril or enalapril); * A: Angiotensin receptor blockers (ARB; e.g., losartan or valsartan) * B: β-blockers (e.g., atenolol, metoprolol, or bisoprolol) * C: Calcium antagonists (e.g., nitrendipine, nifedipine, or amlodipine) * D: Diuretics (e.g., hydrochlorothiazide, indapamide, or indapamide SR tablets) 3. Has an outpatient clinic for hypertension treatment and staff are willing to take part in the study. Inclusion Criteria for Participants: 1. Age ≥35 years and \<80 years 2. Local resident of the community/township who attends the PHC clinic for hypertension management, and will not travel for more than 3 months during the study period; 3. Established diagnosis of essential hypertension, with uncontrolled BP before randomization (defined as office BP≥140/90mmHg, and 24-hour ambulatory BP≥130/80mmHg); 4. Own and be able to use a smartphone daily; 5. Be willing to participate in the study and sign the informed consent. Exclusion Criteria for participants: 1. Physician-diagnosed or suspected secondary hypertension (e.g. hypertension caused by renal disease, renal artery stenosis, aortic stenosis, primary aldosteronism, pheochromocytoma/paraganglioma, Cushing's syndrome, thyroid dysfunction, intracranial disease, drug- induced, or rare monogenic genetic disease), or the presence of other structural heart diseases, such as aortic insufficiency, hypertrophic cardiomyopathy, or congenital heart disease; 2. Office or ambulatory SBP≥180 mmHg and/or DBP≥110 mmHg before randomization; 3. Physician-diagnosed atrial fibrillation; 4. Physician-diagnosed CKD, estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73 m2 (if serum creatinine is available), or currently on dialysis treatment; 5. Physician-diagnosed hepatic dysfunction, or ALT≥ 2\*ULN; 6. Currently at the unstable or terminal stage of any disease (e.g. new- onset cardiovascular and cerebrovascular diseases occurred within 3 months, malignant tumors); 7. Intolerance to at least two classes of antihypertensive medications among A, B, C or D; 8. Currently taking 3 or more antihypertensive drugs; 9. The subject is pregnant or breastfeeding, or planning to become pregnant or breastfeeding during the study period; 10. Have communication or cognitive disorders; 11. Be unwilling to take antihypertensive drugs, or assumed poor adherence to treatment; 12. The subject is participating in other clinical trials at the moment.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Essential hypertension are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases
Beijing, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new pill crack the code of stubborn high blood pressure?
- Inflatable leg cuffs tested as a Two-for-One therapy for high blood pressure and erectile dysfunction
- Can nurses and home monitors tame high blood pressure?
- Can pressing six points on the body help older adults sleep?
- Can AI-Tailored heat warnings shield chronic disease patients from dangerous temperatures?
- Could a quieter, automated blood pressure check help more people control hypertension?