Coronary restenosis

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

Researchers are testing whether a balloon catheter coated with the drug sirolimus can safely open narrowed coronary arteries in adults with heart disease. The balloon inflates to press the drug into the artery wall, aiming to keep the vessel open without leaving a permanent stent…

This trial tests whether tailoring breathing support to each patient protects the lungs better than a standard fixed setting during heart bypass surgery. Researchers will compare two methods of setting positive end-expiratory pressure, or PEEP, in 86 adults having on-pump coronar…

This study tests whether taking a low dose of colchicine (a medicine used for gout) every day for a year can prevent the new blood vessels created during heart bypass surgery from failing. About 100 adults who recently had bypass surgery will take colchicine or no extra treatment…

This trial tests whether high-intensity interval training (HIIT) or a home-based rehabilitation program can better improve exercise capacity in people who have had coronary artery bypass graft surgery. Participants, who are clinically stable and at low to moderate risk, will be a…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This trial is testing a new coronary extension catheter designed to help doctors deliver balloons and stents more easily during percutaneous coronary intervention (PCI) for coronary artery disease. The study will enroll about 69 adults who need PCI and for whom the catheter is pl…

This study tests a new balloon coated with sirolimus (Virtue SAB) against an existing balloon coated with paclitaxel (AGENT DCB) for treating in-stent restenosis — when a previously placed stent in a heart artery becomes blocked again. About 740 people with one re-narrowed stent …

This study looks at two different ways to use a heart-lung machine (ECMO) during high-risk heart procedures. One method sets up the machine just in case it's needed, while the other uses it from the start. The goal is to see which approach leads to fewer serious problems like dea…

This study tests a special balloon coated with a drug (paclitaxel) to open blocked heart arteries. About 1,200 adults with coronary artery disease will receive either the Prevail balloon or another similar balloon. The goal is to see if the Prevail balloon is safe and works well …

This study aims to see if using tiny cameras inside the heart's arteries during stent placement leads to better outcomes for people with complex coronary artery disease. About 11,000 adults in the Netherlands who need a stent for severe blockages will be included. The goal is to …

This registry is following 10,000 people who receive the BioFreedom Ultra stent, a device coated with the drug biolimus A9 to keep heart arteries open. The goal is to see how well the stent works in real-world patients, not just in controlled trials. Researchers will track proble…

This study looks at whether using a temporary mechanical heart pump during a high-risk heart procedure (PCI) can improve safety and outcomes. About 98 adults with weak hearts and complex blockages will be randomly assigned to receive the pump or standard care. The goal is to see …

This study tests a special balloon coated with two drugs to open blocked heart arteries in people with chest pain or minor heart attacks. The balloon is used instead of placing a new stent. About 30 participants will be followed for 12 months to see if the artery stays open and i…

This study tests two methods to fix a common problem: a heart stent that hasn't opened fully (underexpansion). One method uses a balloon to push the stent open, the other uses shock waves (lithotripsy) to crack the blockage. About 80 people with narrowed stents will be randomly a…

This study compares two methods for guiding a second stent procedure in people whose drug-coated stents have re-narrowed. One method uses standard X-ray (angiography), the other adds detailed imaging from inside the artery. The goal is to see which approach leads to fewer major h…

This study looks at whether taking two blood thinners (ticagrelor plus aspirin) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be che…

This study tests whether a comprehensive treatment plan can reduce heart attacks and other serious events in people with rapidly-progressive coronary artery disease tied to inflammation. Researchers will compare each participant's outcomes before and after treatment. The study en…

This study looks at whether SGLT2 inhibitors (drugs like empagliflozin and dapagliflozin, typically used for diabetes) can prevent acute kidney injury caused by contrast dye used in heart X-rays and stent procedures. Researchers will review records of 4,000 patients who had these…

This study tests whether an ultra-high-resolution CT scan, called photon-counting CT angiography, can accurately detect narrowing inside brain stents. The trial involves 200 adults who have had a stent placed in a brain artery and are due for a follow-up check. The new CT scan's …

This study is testing whether a new type of CT scan, called photon-counting CT, can do it all in one go for people who have had a coronary stent placed. The scan aims to check the stent and arteries, measure blood flow to the heart muscle, and assess heart function in a single ex…

This study tests a new technology called IVUS-FFR that uses ultrasound images from inside heart arteries to quickly check if a blockage is serious enough to need a stent. Unlike the current standard test, it doesn't require an extra pressure wire or medication that can cause disc…

This study tests whether giving a set of nerve blocks (injections of numbing medicine) right after anesthesia but before surgery can reduce pain and the need for opioid painkillers after coronary artery bypass grafting. 56 adults scheduled for elective bypass surgery will be rand…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and opioid use after minimally invasive heart bypass surgery. Sixty adults undergoing this surgery will be randomly assigned to receive either the nerv…

Researchers at University Hospital Basel are collecting information from routine care to compare treatments for coronary artery disease. The registry follows people who receive a percutaneous coronary intervention, including complex procedures, and who are treated with drug-eluti…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study tracks 500 adults with stable coronary artery disease or unstable angina who are undergoing a heart procedure called percutaneous coronary intervention (PCI) using a drug-coated balloon. Researchers are looking at how procedural details—specifically how long the balloo…

This study aims to understand why fatty plaques in heart arteries suddenly rupture, causing heart attacks, and why some people experience more heart muscle damage than others. Researchers will use advanced imaging, blood tests, and genetic analysis in about 2,000 patients undergo…

This trial asks whether high-risk patients who receive a stent for coronary artery disease benefit from a routine angiography scan about a year later, compared to usual clinical follow-up without routine imaging. The study enrolls adults who had successful stent placement and hav…

This study is a global registry that collects data from adults undergoing coronary angiography or percutaneous coronary intervention (PCI) — procedures that open blocked heart arteries. The goal is to track how often complications occur during these procedures, what strategies do…

This study will follow 20,000 patients with complex coronary artery disease to see how non-fatal complications during a heart procedure (stent placement) affect their risk of death over the long term. Researchers aim to identify which complications are most dangerous. The study d…

This study is observing 20,000 people undergoing routine heart or blood vessel procedures through the wrist (radial or ulnar artery). Researchers will track complications like artery blockage, spasm, and bleeding. The goal is to gather real-world data to improve safety and succes…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study reviews the long-term heart health of 1,500 patients who received a drug-eluting balloon to treat coronary artery disease between 2010 and 2025. Researchers will track major heart events like heart attacks, strokes, and repeat procedures. The goal is to better understa…

This study looks at how aging inside our cells might make heart arteries more prone to dangerous plaques. Researchers will measure DNA damage and other aging markers in 300 adults with different types of chest pain or heart attacks. The goal is to find better ways to predict who …

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This trial tests whether using a wrist artery access point closer to the hand (distal radial) is safer than the usual wrist access for complex heart procedures like opening blocked arteries. About 708 adults with stable or unstable heart conditions will be randomly assigned to on…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study aims to learn more about heart disease that is linked to inflammation but does not progress quickly. Researchers will follow 120 adults with this condition to track their treatments and health outcomes, such as heart attacks or the need for procedures. The goal is to b…

This study is collecting information from 3,000 people who receive a special drug-coated balloon to open blocked heart arteries. The goal is to see how effective and safe the balloon is in real-world use, including for different types of blockages and patient conditions. Research…

This study tests whether artificial intelligence can evaluate how well surgeons perform a key step in heart bypass surgery. Researchers will compare AI scores to those from human experts. The trial involves 284 patients undergoing bypass grafting and aims to see if AI can reliabl…