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Lighter breathing on Heart-Lung machine may cut Post-Surgery delirium

NCT ID NCT06752421

Disease control Sponsor: Nevsehir Public Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery can lower the risk of postoperative delirium—a state of confusion that can slow recovery. Researchers compared 130 patients who received either low tidal volume ventilation or no ventilation during bypass. The main goal was to see if the gentle breathing approach reduced delirium rates, ICU stay, and 30-day complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low tidal volume ventilation (a breathing machine setting during surgery)
What this could lead to
If it works, this could point toward a simple way to lower confusion and improve recovery after heart surgery.
What could go wrong
This is a small, single-center trial. The results may not apply to all patients or hospitals, and the effect on delirium may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

130 people

The number who actually took part.

Started

Jan 2025

Finished

Feb 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All male or female patients over the age of 18 * Patients undergoing planned cardiac surgeries including CABG * Patients with an American Society of Anesthesiologists (ASA) physical status of II, III, or IV Exclusion Criteria: * Emergency surgeries will be excluded due to the high likelihood of non-compliance with the protocol and the potential lack of essential patient information. * Surgeries requiring single-lung ventilation will be excluded as they may cause confusion in determining any effects of the intervention due to the inability to apply the study intervention and the differential treatment of the lungs. * Patients who meet delirium criteria according to 3D-CAM measurements during the initial visit will be excluded. * Patients with a life expectancy of less than 6 months or a history of psychiatric or neurological diseases (including depression, severe central nervous system depression, schizophrenia, epilepsy, Parkinson's disease, and Alzheimer's disease) will be excluded. * Severe impairments such as blindness, severe deafness, or dementia that may hinder cognitive testing will be excluded. * Patients using psychotropic or opioid medications, those with a history of delirium, or those with a history of alcohol abuse or withdrawal within the past 6 months will be excluded.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction coronary artery disorder Emergence Delirium Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiopulmonary bypass Cognitive dysfunction, postoperative Low tidal volume ventilation Postoperative delirium (POD)

Contacts and locations

Locations

  • Konya City Hospital

    Konya, Karatay, 42030, Turkey (Türkiye)

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