Hormone clues may unlock secrets of dangerous blood pressure
NCT ID NCT07535814
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at 500 adults hospitalized with dangerously high blood pressure. Researchers measured levels of the hormone aldosterone to see if it relates to how long patients stay in the hospital or if they have complications. The goal was to better understand the condition, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better predict which patients with severe high blood pressure are at higher risk, leading to more personalized care.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly improve patient outcomes. Results may not change current practice without further research.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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500 people
The number who actually took part.
- Started
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Mar 2022
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients admitted to hospital due to acute severe hypertension, identified from institutional databases. The study population includes individuals with available biochemical assessment of the renin-angiotensin-aldosterone system at admission, allowing evaluation of aldosterone-related pathophysiological phenotypes and their association with short-term clinical outcomes.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adults aged ≥18 years Hospital admission due to acute severe hypertension, defined as systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥120 mmHg requiring in-hospital management Availability of plasma aldosterone and renin measurements at hospital admission or within the first 24 hours Availability of key clinical and laboratory data, including blood pressure, renal function, and serum potassium levels Exclusion Criteria: Pregnancy or hypertensive disorders of pregnancy Known secondary hypertension due to endocrine causes other than suspected aldosterone dysregulation (e.g., pheochromocytoma, Cushing syndrome) Patients receiving chronic dialysis Severe acute conditions likely to independently determine short-term outcomes (e.g., septic shock, major trauma) Missing key data required for primary outcome assessment (length of hospital stay) Prior inclusion in the study cohort \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Laura Grazini
Godoy Cruz, Mendoza Province, 5501, Argentina
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