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Could your gums affect your heart health? new study investigates

NCT ID NCT07449546

Knowledge-focused Sponsor: Ankara University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. The goal was to understand if oral health might play a role in heart-related conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

61 people

The number who actually took part.

Started

Feb 2022

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients (≥18 years) with confirmed peripheral arterial disease (PAD) who were referred for vascular evaluation were enrolled in this cross-sectional observational study. Participants had intact limbs and were categorized according to their periodontal status as periodontitis, gingivitis, or edentulous (with self-reported history of tooth loss due to advanced periodontitis). All participants met the predefined inclusion and exclusion criteria prior to enrollment.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria: * Adults aged ≥18 years * Confirmed diagnosis of Peripheral Arterial Disease (PAD), defined as: Ankle-Brachial Index (ABI) \< 0.9 and/or angiographic or ultrasonographic evidence of arterial stenosis * No limb amputation * Presence of teeth and willingness to undergo full-mouth periodontal examination * Edentulous status with self-reported history of complete tooth loss due to advanced periodontitis * Ability to provide informed consent Exclusion Criteria: * Pregnant individuals * Use of oral contraceptives * Systemic antibiotic use within the previous 3 months * Corticosteroid use within the previous 3 months * Immunosuppressive therapy within the previous 3 months * Chronic non-steroidal anti-inflammatory drug (NSAID) use within the previous 3 months * Active periodontal treatment within the previous 6 months * Periodontal surgery within the previous 1 year

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Edentulism Periodontal diseases Peripheral arterial disease

Contacts and locations

Locations

  • Ankara University Faculty of Dentistry

    Ankara, Ankara, 06560, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.