Substance-related disorder

This study tests an adaptive web-based program called Partners Connect for military couples. It aims to reduce drinking in concerned partners and encourage service members to seek help for alcohol use. About 744 couples will participate, comparing the online program to standard w…

This study is testing whether e-cigarettes (nicotine vapes) can help people who are in treatment for substance use disorder quit smoking. Participants will either switch to e-cigarettes or use FDA-approved nicotine patches and lozenges, with weekly counseling. The goal is to see …

This phase 2 trial tests whether semaglutide, a GLP-1 drug used for diabetes and weight loss, can help adults with opioid use disorder avoid using illicit opioids. Participants already receiving buprenorphine or methadone treatment will take weekly semaglutide or a placebo for 12…

This trial tests whether giving prolonged exposure therapy for PTSD in a massed format, with multiple sessions each week, works as well as the standard once-a-week schedule for veterans who are also in intensive outpatient treatment for substance use disorder. Researchers will co…

This study tests whether an 8-week culturally responsive harm reduction program helps Black and Latinx people who use drugs engage more with services and reduce opioid or stimulant use. Researchers will compare the program to standard harm reduction services in 200 participants. …

This phase II trial is investigating whether MDMA-assisted therapy can reduce PTSD symptoms in veterans with moderate to severe PTSD. Participants will receive either MDMA or a low dose of d-amphetamine (as an active control) alongside psychotherapy. The study aims to compare cha…

This study investigates whether a mobile app called reSET can help men who have sex with men, are living with HIV, and have a stimulant use disorder reduce their drug use and keep their HIV under control. Participants use the app for 12 weeks, completing modules on topics like ma…

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study tests a computerized task where teens push or pull a joystick in response to images, aiming to change automatic habits around cannabis and alcohol. Fifty-two participants aged 13-17 who use both substances will be followed for three months. The goal is to see if this s…

This study tests a mobile app and financial rewards to help veterans quit smoking before major elective surgery. Smoking increases the risk of complications after surgery, but quitting can be hard. The program uses a carbon monoxide monitor and app to verify abstinence, with ince…

This trial tests whether heart rate variability biofeedback (HRVB) — a technique that uses guided breathing to improve the body's stress response — can help veterans with both PTSD and substance use disorder. Participants will be randomly assigned to receive either HRVB or presen…

This trial tests whether an 8-week virtual mindfulness program can help substance use peer workers reduce their own relapse risk and burnout. Peer workers—people in recovery who support others with substance use issues—often face high stress. The study compares the mindfulness pr…

This study tests a program called Returning to the Land, designed for young Native American caregivers (ages 14-19) who have a child aged 1-5. The program uses time in a biodiverse outdoor setting to address caregiver substance use and support children's emotional and behavioral …

This study tests two types of non-invasive brain stimulation (rTMS) to help veterans stop smoking. About 56 veterans who smoke at least 10 cigarettes a day will receive either standard or precision-guided rTMS over three weeks. Researchers will measure how much smoking decreases …

This study examines whether adding structured high-intensity physical exercise to a 3-month residential treatment program for substance use disorder improves patients' physical health, mental health, and quality of life. Researchers measure changes in oxygen uptake, leg strength,…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This study tests whether cognitive behavioral therapy (CBT) for parents of very premature infants in the NICU can reduce feelings of child vulnerability and improve the child's development. Parents in the intervention group receive five CBT sessions during and after the NICU stay…

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This study will enroll 270 pregnant Native American and Alaska Native women with substance use disorders. Researchers will adapt standard pregnancy and addiction care to better fit Native cultural needs. The goal is to help mothers stay in treatment and attend follow-up visits af…

This trial tests whether a helmet that delivers focused ultrasound waves can safely change brain activity in people with moderate-to-severe substance use disorder who haven't responded to medication. Participants receive two MRI-guided sessions targeting brain regions linked to a…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests a program called Fathers for Change (F4C) for 280 fathers who struggle with substance misuse and have been violent toward family. The program aims to help them control emotions, stop substance use, and prevent violence. Researchers compare F4C to standard drug co…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study tests whether 8 weeks of combined resistance breathing training and aerobic exercise can improve physical health and quality of life in male drug rehabilitation patients. Ninety men aged 18-50 will be randomly assigned to one of three groups: combined training, breathi…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This study tests a program called Hastiin Bidziil (Strong Man) to help Native American men ages 18 and older reduce their use of alcohol and drugs. About 160 men from Arizona communities will take part. The program focuses on cultural strengths and community support to lower subs…

This study tests a digital group program called WORTH Paths for women aged 18-44 who have been involved in the criminal legal system, have a substance use disorder, and need contraception but aren't using it. The program includes three virtual group sessions with interactive acti…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests a program called Peer Activate, where trained peer recovery specialists help people with opioid addiction stay on their medication and cut down on other drug use. The program teaches skills like finding rewarding activities without drugs. Researchers will compare…

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study looks at how to bring a program called Just Care for Families to more counties in Oregon. The program helps parents who use opioids or methamphetamine reduce their substance use and improve family outcomes, like being reunited with their children. Researchers will test…

This study tests whether a special therapy program with a mobile app helps pregnant people stay on their buprenorphine medication for opioid use disorder, compared to just logging their doses. About 37 pregnant women will be randomly assigned to either the app-based therapy or da…

This study is testing whether a type of brain stimulation called theta burst stimulation (TBS) can reduce heavy drinking and cravings in people with alcohol use disorder. Researchers will apply magnetic pulses to a brain region linked to drinking patterns, comparing real stimulat…

This study looks at whether taking part in a traditional Ojibwe ceremony called Gii'igoshimong can help American Indian adults cut down on substance use and improve their mental health. About 300 adults who identify as Ojibwe/Anishinaabe/Chippewa and have used substances in the p…

This study tests a new type of brain stimulation (rTMS) as a treatment for cannabis use disorder. Researchers will enroll 46 adults who use cannabis frequently and want to cut back or quit. The goal is to see if the treatment is safe, tolerable, and can reduce cravings and use.

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follic…

This study tests two digital treatment programs for people recently released from prison who have a history of substance use problems. The goal is to see if these programs are practical and helpful in preventing relapse and return to prison. About 20 participants will use the dig…

This study tests whether a 1-month meditation app can help youth on probation (ages 13-20) reduce cannabis use and risky sexual behaviors by improving emotion regulation. Researchers will enroll 300 participants in Cook County, IL, and measure changes in substance use, mood, and …

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study looks at whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks is feasible and acceptable for people with moderate to severe methamphetamine use disorder. About 80 participants will receive either the drug or a placebo alongside their usual …

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether giving financial incentives for negative drug tests can help people with opioid, cocaine, or methamphetamine use disorder stay abstinent. Six hundred participants use a smartphone app to submit saliva tests. Some receive escalating or de-escalating reward…

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study is testing whether virtual reality (VR) training can help people with substance use and mental health disorders improve their social functioning and quality of life. Researchers will compare VR training plus standard care against standard care alone in 102 adults recei…

This study tests whether a trauma-focused group therapy (CPT-CJ) given in prison can reduce drug use, PTSD symptoms, and re-arrest after release. 640 incarcerated adults from about 10 prisons will either receive the group therapy or a self-help workbook. Researchers will also mea…

This study tests whether adding a caregiver session to a brief alcohol counseling program helps teens aged 12-17 reduce their drinking. 615 teens with mild alcohol problems will be assigned to teen-only counseling, counseling with a live caregiver session, or counseling with an o…

This study looks at whether treating obstructive sleep apnea (OSA) early with a positive airway pressure (PAP) device can improve outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive PAP therapy…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study tests whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder drink less heavily. About 330 Veterans will either get medication alone or medication plus the app. The goal is to see if the app makes treatment more effective and ea…

This early study tests whether personalized deep brain stimulation (DBS) can safely reduce cravings and opioid use in 6 adults with severe, treatment-resistant opioid use disorder. Researchers will first map brain activity to find each person's craving signals, then deliver targe…

This early-stage study will test whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for people trying to quit methamphetamine. Twenty adults in northern Louisiana who want to stop using meth will receive psilocybin in a controlled setting. Researc…

This study tests a community program called Young HEROES for youth aged 12-17 with opioid use disorder. It combines medication, counseling, and peer support to help them stay in treatment and stop using opioids. The goal is to see if this approach works better than usual care in …

This trial tests a peer-led program called PEGISUS to reduce substance use and promote fair gender beliefs among 264 young people (ages 16-24) in vocational training in Zambia, Zimbabwe, and South Africa. Participants in peer groups will attend eight sessions, while a control gro…

This study is testing whether a mobile app called Pink Cloud can help people recovering from drug or alcohol problems stay sober. Over 1,400 adults who have completed treatment will use the app for a year, which includes a meeting finder, sobriety tracker, and planning tools. Res…

Researchers are testing whether a three-session couples motivational interviewing program helps male couples reduce illicit drug use and behaviors that raise HIV transmission risk. The trial enrolls 360 male couples where at least one partner is HIV negative and at least one has …

This trial tests a police education program called SHIELD 2.0 in nine counties in Appalachian Kentucky. The program trains local behavioral health workers to teach police how to refer people who use drugs to treatment and social services instead of arresting them for low-level po…

This study tests two counseling programs—one focused on motivation and coping skills, the other on strengths and advocacy—to prevent opioid misuse in 300 homeless youth aged 14-24. Participants are randomly assigned to one of the programs or standard services, and tracked for two…

This study is developing and testing a virtual reality tool to help young people aged 15-30 who have experienced trauma and are at risk for substance use and HIV. The goal is to see if the tool can reduce substance use and risky behaviors. Researchers are recruiting young men who…

This study tests whether a 'practice coaching' program can help opioid treatment clinics offer more HIV and hepatitis C testing to their patients. Clinics are randomly assigned to receive either coaching focused on HIV testing, coaching that adds hepatitis C testing, or just info…

This pilot trial tests a counseling program called CHOICES-PLEAS for women in a jail-based substance use treatment program. The goal is to reduce the risk of substance-exposed pregnancies by helping women change their substance use and risky sexual behaviors. Participants receive…

This study is creating and testing short videos for teens (ages 12-17) and their parents after a traumatic injury that requires a hospital stay. The goal is to prevent posttraumatic stress disorder (PTSD) and substance use. The videos will be developed with input from families an…

This study tests a program called PREVENTURE for teenagers aged 14 to 17 who are at risk for alcohol and drug addiction. Participants are randomly assigned to either the program plus usual care or usual care alone. The goal is to see if the program reduces binge drinking and othe…

This study tests whether a program called Bright Horizons can help prevent binge drinking and drug use in Native American youth aged 10 to 24. The program teaches skills like managing emotions, coping with stress, and setting goals. Researchers will compare it to standard case ma…

This study tests an online parenting program called Family Check-Up Online, adapted for Latinx families, to help prevent substance use in youth aged 11-14. Researchers will enroll 108 Latinx families and compare a culturally adapted version, a Spanish-only version, and a waitlist…

This study aims to create and test a prevention program for e-cigarette use among 6th-8th graders in rural Hawaii. The program includes classroom lessons, social media content, and a print campaign, all designed with Hawaiian culture in mind. Researchers will work with 500 studen…

This study tests a 9-month program called NE+ for American Indian youth aged 12-18. The program includes educational modules and cultural teachings to encourage abstinence, condom use, and avoid substance use. It also involves parents and school staff. The goal is to see if the p…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a web-based program called T.E.C.H. Parenting that teaches parents of middle-schoolers how to talk about media and set rules around it. The goal is to reduce kids' exposure to substance use in movies, shows, and online content, which may lower their risk of tryin…

This study tests whether adding extra supports—like telehealth coaching and practical help—to a group parenting program can prevent language delays in young children (12-42 months) of parents with substance use disorders. 244 parents will be assigned to the group program alone or…

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12-17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience. The goal is to prevent substance …

This study tests a support service designed specifically for transgender women, men, and non-binary people in Thailand who have used chemsex drugs or other substances in the past year. The program offers HIV prevention (PrEP), mental health support, and STI care. Researchers will…

This study tests a program called Mobile Enhanced Prevention Support (MEPS) for people recently released from jail or prison who have substance use disorders. The program pairs participants with a peer mentor, offers cash incentives for using health services, and provides a smart…

This study is testing whether a long-acting injectable HIV prevention drug, called cabotegravir, can work for people who inject drugs. The trial will enroll 100 adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sexual contact. Pa…

This study tests an after-school program called Native Spirit for Indigenous teens in grades 7-12. The program uses cultural activities to strengthen identity, self-esteem, and resilience, with the goal of preventing substance use. About 60 teens from two Arizona tribes will take…

This study aims to see if training people who inject drugs to become peer educators can help their friends get tested for HIV and use prevention tools like PrEP and treatment for opioid use. About 360 participants from syringe service programs in Maryland will be recruited, along…

This study tests whether using a mobile app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 participants will either use the active SSP or a sham version for up to 5 hours over a week, alongsi…

This study tests whether a brain-training technique called neurofeedback can help people with opioid use disorder who are on methadone feel more pleasure and recall positive memories. Participants learn to control their brain activity using real-time fMRI scans, a method that has…

This study tests whether low-intensity focused ultrasound (LIFU) can safely calm overactive brain areas linked to alcohol cravings. Twenty-five adults with alcohol use disorder will receive LIFU while researchers monitor side effects and measure brain activity changes with fMRI. …

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) to reduce nicotine cravings and vaping. 120 adults who vape heavily will receive either real TI stimulation to deep brain areas linked to addiction or a sham (fake) treatment during a …

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This trial tests a peer-led program called Honest, Open, Proud (HOP) for veterans with mental health or substance use disorders who have been involved with the justice system. The program helps participants decide whether, when, and how to disclose their conditions, with the goal…

This trial tests a virtual program called iPAWS for adolescents and young adults having their wisdom teeth removed. The program teaches safe, effective ways to handle post-surgical pain and aims to reduce cannabis and other substance use. Researchers are enrolling 150 participant…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with overweight or obesity quit smoking. 300 smokers will receive either the drug or a placebo, plus nicotine patches, for 16 weeks. The goal is to see if the drug improves quit rates …

This early-phase study tests whether a device that delivers specific smells can reduce cigarette cravings and help people stop smoking. About 132 smokers will use a smartphone app with or without the scent device for a week, then report cravings and quit attempts. The goal is to …

This study tests a therapy called Mothering from the Inside Out (MIO) for mothers recovering from substance use disorders. The goal is to help them build stronger relationships with their young children and reduce parenting stress. Researchers will enroll 200 mothers from outpati…

This study partners with community organizations to adapt a smoking cessation program for adults who smoke and receive care at behavioral health clinics. Researchers will enroll 24 participants to test whether the program is feasible and acceptable. The goal is to learn how to be…

This early-phase study is testing whether adding two doses of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for adults with opioid use disorder. Ten participants will receive psilocybin along with counseling, while rese…

This study tests a hybrid dialectical behavior therapy (DBT) program for veterans with PTSD who have already completed inpatient treatment. The goal is to reduce lingering symptoms and prevent relapse. About 24 veterans will take part, combining in-person skill groups with online…

This study tests a wearable earpiece that gently stimulates nerves to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device or a sham version for 5 days during detox. Researchers will measure withdrawal severity, cravings, and …

This study tests whether an app-based therapy called A-EMDR can help people who have both PTSD and substance use disorders. Twenty-four adults will use the app three times a week for four weeks, while researchers track changes in PTSD symptoms and substance use. The goal is to se…

This study tests whether ear acupuncture, combined with mindfulness therapy, can reduce emotional distress in active-duty service members and veterans with PTSD. Sixty-six participants will receive either mindfulness therapy alone or mindfulness plus a one-time ear acupuncture tr…

This study tests whether peer recovery specialists—people who have themselves recovered from mental health or substance use problems—can effectively deliver a therapy called behavioral activation to reduce depression and substance use. The trial will enroll 250 low-income adults …

This study tests a 6-month holistic behavioral health program called EASE for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, case management, peer support, and education. Researchers will measure changes in depression…

This early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…

This study tests whether a gentle brain stimulation technique (tDCS) combined with cognitive training can reduce cravings in people with cocaine addiction. 120 participants will receive either real or sham stimulation for 20 minutes a day, three times a week, for five weeks. Rese…

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both posttraumatic stress disorder (PTSD) and a substance use disorder. About 170 veterans will complete five writing sessions about their trauma. The goal is to see …

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study tests whether an 8-week personalized occupational therapy program can help people with substance use disorder perform daily activities better, feel more confident, and bounce back from stress. About 34 adults who have completed detox will be split into a therapy group …

This study tests a 12-week group therapy program called ECCCLORE for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, distress, and relationships. Researchers want to see if it is feasible and acceptable …

This study tests a digital program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use while also addressing relationship conflict. Forty men entering addiction treatment will use t…

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder (like Suboxone or methadone). Over 10-12 weeks, they will attend therapy sessions and complete surveys to see if their …

This study tests a digital app called Enhearten designed to reduce self-stigma in pregnant and postpartum women with substance use disorder. The app provides just-in-time support to help women feel less judged and stay on track with addiction treatment. Researchers will compare t…

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests whether a condensed form of PTSD therapy, called Massed Prolonged Exposure (M-PE), can help people who are also being treated for substance use disorders. About 168 adults will either receive M-PE alongside their usual substance use program or continue with stand…

This study looks at three different ways to manage pain after childbirth in women who are on medication for opioid use disorder. The goal is to find which method works best for pain control and whether it also helps reduce anxiety, depression, and improve overall well-being. Abou…

This study tests a program called Contingency Management that gives Veterans rewards for quitting smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger trial…

This study tests an online program called OurRelationship-S, designed for couples where one or both partners are in recovery from substance misuse. The program includes about 8-10 hours of digital content and five coaching calls over 5-8 weeks, aiming to improve relationship sati…

This pilot study tests whether suvorexant, a sleep medication, can improve sleep, reduce stress, and lower drug cravings in people who recently stopped using stimulants like cocaine or methamphetamine. Twenty participants will receive either the drug or standard care for 7 days w…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…

This study aims to create a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants will use an app that tracks phone activity and location, and answer short surveys about mood and substance use. The goal is …

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study will give 22 occasional cannabis users oral THC, CBD, both, or a placebo to measure how these substances appear in blood and saliva, and how they affect thinking and behavior. The goal is to better understand drug detection and impairment from oral cannabinoids. It is …

This study tests a 10-week parenting program called Parenting in 2 Worlds (P2W), designed specifically for urban American Indian families. Researchers will compare it to a general health program in four U.S. cities with 1,440 parent-teen pairs. The goal is to see if P2W improves …

This study explores whether a short substance use questionnaire and brief counseling session can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 participants will fill out a screening tool and, if needed, receive supportive counseling during…

This study will follow 40 adults aged 18-70 who currently take tirzepatide, a medication for blood sugar and appetite control. Researchers will temporarily stop the drug for 3-4 weeks and then restart it for 6-8 weeks, using brain scans, questionnaires, and stool samples to track…

This study screens up to 10,000 adults aged 18-99 who have current, past, or no substance or alcohol use disorders. Participants undergo one visit with tests like physical exams, blood work, memory tests, and mental health evaluations. The goal is to find eligible volunteers for …

This study tests a device that has not been approved by the U.S. FDA. The purpose is to collect information on how the device works and its safety. Participants will help researchers understand if the device could be useful in the future.

This study looks at whether doulas with extra training in mental health support can help pregnant women in rural Montana feel more confident and less depressed. About 75 pregnant women will be split into three groups: one with a specially trained doula, one with a regular doula, …

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study tests a new program for adults in prison who have both ADHD and substance use disorder. The program includes workshops to improve care and support. Researchers will check if the program is acceptable and if it improves quality of life.

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study tests a training program called INSPIRE designed for healthcare teams caring for people with substance use disorder during childbirth. The program includes online learning and in-person simulations. Researchers want to see if the training changes healthcare providers' …

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…

This study will test whether a mobile app that teaches people about how addiction affects the brain is easy to use and acceptable for people receiving medication treatment for opioid or stimulant use disorders. Forty participants will use the app and complete surveys. The goal is…

This trial compares an online training program (COPEWeb) to in-person training for behavioral health providers. The goal is to see if the online version is as effective at teaching providers to deliver a combined treatment for PTSD and substance use disorders. Providers will be r…

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study follows 400 parents in rural Ohio who are part of the Ohio START program, which connects them to substance use treatment and peer mentors. Researchers want to see if having treatment services close to home and strong social support helps parents recover and improves th…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study works with Black teens on probation and their families to adapt alcohol and drug treatment to better address experiences of racial discrimination. Researchers will interview teens and hold focus groups with parents and community advocates to learn what works. The goal …

This study looks at how alcohol and substance use affect people with severe mental illnesses like schizophrenia and bipolar disorder. Researchers compare those who also have substance use problems with those who do not, measuring things like hospitalizations, medication needs, em…

This study looks at whether federal policy changes made during the COVID-19 pandemic helped more veterans get and stay on medication for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data …

This phase 1 trial at Ohio State University is studying how nicotine analogs compare to regular nicotine in e-cigarettes. Researchers want to understand if these newer chemicals are just as addictive and what they do to the heart and blood vessels. The study involves 70 adult e-c…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This study looks at how preterm and full-term babies adapt to noises and lights—a skill called habituation. Researchers will compare 70 infants near their due date to see if differences in this ability can help spot those at risk for developmental delays. The goal is to find earl…

This study looks at how differences in personality, brain activity, and behavior may make some young adults more likely to use substances like cannabis. Researchers will track eye movements and brain scans in 294 people aged 18-22. No treatment or medication is involved—the goal …

This study is testing a program called Project REACH, which offers telehealth services at syringe service programs (places where people can get clean needles). The goal is to see if this makes it easier for people who use drugs to get HIV prevention (like PrEP) and addiction trea…

This study follows 35 men in residential rehab for severe substance use. They write weekly stories about their feelings and challenges, and fill out questionnaires every two weeks. Researchers use natural language processing to analyze the stories and look for patterns that might…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study looks at whether a special training and support program can help addiction clinics start using contingency management, a proven method that gives rewards to patients who stay off stimulants. Researchers will work with 76 clinics and track how many patients and counselo…

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study looks at two different approaches to help pregnant and postpartum people get better mental health care. One approach focuses on improving care within doctor's offices, while the other partners with community groups. About 1,270 participants across 32 U.S. clinics will …

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study is collecting information from 80 adults who have both ADHD and an addiction. Researchers will track their symptoms and daily functioning over 12 months to better understand how these conditions affect each other. The goal is to gather data that could improve future tr…

This study looks at how sleep and body clocks affect the brains of teenagers and their risk for using substances like alcohol or drugs. Researchers will monitor the sleep patterns and brain activity of 200 healthy teens aged 13-18. The goal is to understand how changes in sleep a…

This study tests whether adding a tool called the Pleasuremeter to standard harm reduction services helps men who have sex with men and transgender people who use drugs or engage in chemsex talk about and improve their sexual pleasure. The goal is to see if people are willing to …

This study interviews 50 transgender adults in Thailand about their chemsex behaviors—reasons, patterns, and impacts—along with stigma and HIV prevention needs. Researchers also gather input from stakeholders to identify barriers and facilitators for creating transgender-friendly…

This study is gathering information from men who have sex with men who take part in chemsex (using drugs before or during sex) in Bangkok, Thailand. Researchers will survey party hosts and guests about their drug use, sexual health, mental health, and experiences of stigma. The g…

This study aims to develop a new tool to measure outcomes in substance use disorder treatment. Researchers will interview patients, caregivers, and clinicians to identify key themes and create a questionnaire. The goal is to provide a more accurate way to assess treatment effecti…

This study looks at whether special programs for fathers can help families in the Bronx and nearby areas who are at risk for substance misuse. About 240 fathers will be randomly assigned to either get usual services or extra support like counseling, fatherhood classes, and case m…

This study compares two approaches to screening and counseling teens about alcohol and drug use during primary care visits. One approach involves only the teen, while the other includes the whole family. Researchers will follow 2,300 teens and their caregivers for one year to see…

This study aims to help Oregon decision-makers—like health officials, community leaders, and policymakers—use up-to-date, easy-to-understand data to improve substance use services and prevent overdoses. About 341 adults who have authority over substance use policies or programs w…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study looks at how sleep patterns and stressful events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand why some people drink more. The goal is to use this knowledge to c…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study aims to understand what causes substance use and cravings in veterans, especially when combined with issues like anxiety, depression, or PTSD. Researchers will create a personal model for each participant showing their unique triggers, then give them feedback on how to…

This study watches 363 people with stab or gunshot wounds to the belly to see if alcohol, drugs, or pain medicine changes how fast doctors decide on surgery. It does not test any new treatment—just observes what happens in two hospitals in Colombia. The goal is to learn if these …

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these behaviors and improve quality of life. About 130 English-speaking adults with bipol…

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study tests a method called Feedback Informed Treatment (FIT) in Swedish social services. Social workers will regularly ask clients for feedback using simple rating scales, then adjust support based on what clients say. The goal is to see if this reduces dropout and helps pe…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the compound that makes you high). Researchers will give both substances to 30 regular cannabis users who are not seeking treatment. They want to see if CBD can reduce the abuse potenti…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study tests a 4-session drug education program called iDECIDE for middle and high school students who recently violated their school's substance use policy. About 300 students will be randomly assigned to either take the program right away or wait. Researchers will measure c…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…