Could a sleep drug curb stimulant cravings?

NCT ID NCT06444256

Recruiting now Symptom relief Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study tests whether suvorexant, a sleep medication, can improve sleep, reduce stress, and lower drug cravings in people who recently stopped using stimulants like cocaine or methamphetamine. Twenty participants will receive either the drug or standard care for 7 days while staying in a residential facility. Researchers will track sleep, stress, and craving levels to see if the drug helps with early recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: suvorexant (SUVO)
What this could lead to: If it works, this could point toward a way to improve sleep and reduce cravings during early recovery from stimulant use, potentially helping people stay in treatment longer.
What could go wrong: This is a very small pilot study with only 20 people, so results may not apply widely. It's also early-stage, and the drug may not show clear benefits over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STIMULANT USE DISORDER

Contacts and locations

Locations

The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States

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