Brain scans reveal effects of pausing Weight-Loss drug

NCT ID NCT07387796

Recruiting now Knowledge-focused Sponsor: The University of Texas at Dallas Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will follow 40 adults aged 18-70 who currently take tirzepatide, a medication for blood sugar and appetite control. Researchers will temporarily stop the drug for 3-4 weeks and then restart it for 6-8 weeks, using brain scans, questionnaires, and stool samples to track changes in brain activity, hunger, mood, and behavior. The goal is to understand how the medication affects the brain and daily life, without offering any direct treatment benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide
What this could lead to: If successful, this study could help doctors understand how tirzepatide affects the brain and behavior, potentially improving treatment plans for weight management and substance use disorders.
What could go wrong: This is a small, early-stage study with only 40 participants and no comparison group, so results may not apply to everyone. The temporary medication pause may cause discomfort or side effects.

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Conditions

The condition(s) this trial relates to.

substance withdrawal syndrome substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG DISCONTINUATION EATING BEHAVIOR CHANGES SUBSTANCE USE DISORDERS TIRZEPATIDE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Center for BrainHealth
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

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