Interstitial lung disease

This Phase 1 trial tests the safety and how the body handles HRS-9813, an experimental oral drug for idiopathic pulmonary fibrosis (a lung-scarring disease). Healthy volunteers aged 18-45 take multiple doses to measure side effects and drug levels in the blood. The study does not…

This study tested whether low doses of the hormone drug danazol can slow the shortening of telomeres—the protective caps on DNA—in people with telomere diseases. These conditions can cause bone marrow failure, lung scarring, and liver damage. Eighteen participants took danazol fo…

This study tests an inhaled drug called AGMB-447 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. The main goal is to check safety and how the body processes the drug. 143 participants will receive either the drug or a pla…

This trial tests a 12-week virtual program called Conmigo, designed to help Latina girls aged 8-11 and their mothers become more physically active together. The program includes weekly 1.5-hour sessions with teaching, skill-building, and at least 30 minutes of exercise. Researche…

This study looked at whether using a non-invasive ventilation (NIV) mask right after removing a breathing tube can prevent respiratory failure in obese intensive care patients. About 1000 obese adults were randomly assigned to receive either NIV or oxygen therapy. The goal was to…

This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers com…

This Phase 3 trial tested a drug called efzofitimod in 268 adults with pulmonary sarcoidosis, a condition that causes lung inflammation. Participants received either the drug or a placebo every 4 weeks for 48 weeks. The main goal was to see if the drug could help people safely re…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Researchers measured cha…

This Phase 3 trial tested whether an inhaled drug called treprostinil (Tyvaso) could slow the loss of lung function in 598 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. Participants inhaled the drug or a placebo four times daily for 52 weeks. The ma…

This study tested whether nintedanib, a drug used for other lung diseases, can slow down lung damage in people who had severe COVID-19. It included 103 adults who still had lung problems more than 30 days after their COVID diagnosis. The main goal was to see if the drug helped ma…

This study looked at the long-term safety of an inhaled medication called treprostinil palmitil (TPIP) for people with pulmonary hypertension caused by interstitial lung disease. Thirty-one adults who completed a previous study took part. The main goal was to check for side effec…

This study tested a single intravenous infusion of stem cells from donated umbilical cord tissue in one person with severe scleroderma that had caused lung scarring and high blood pressure in the lungs. The goal was to see if the treatment could improve lung function, exercise ab…

This early-phase study tested a purified green tea extract called EGCG in 50 people with idiopathic pulmonary fibrosis (IPF) who were already taking standard medications. The main goal was to check if EGCG is safe and how it interacts with their usual drugs. Participants took EGC…

This phase 2 trial tested an experimental tablet called HSK44459 in 186 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. Participants took one of three doses of the drug or a placebo twice daily for 12 weeks. The main goal was to see if the dr…

This study tested whether the antioxidant N-acetylcysteine (NAC) can slow lung decline in people with idiopathic pulmonary fibrosis (IPF) who have a specific gene variant (TOLLIP TT). Over 200 participants took NAC or a placebo for 24 months. The goal was to see if NAC delays wor…

This study tested a drug called clomastine fumarate in 28 children aged 3-12 with Williams syndrome, a genetic condition that causes developmental delays. The goal was to see if the drug could improve thinking, movement, and social skills by repairing brain myelin. The study used…

This study tested a new cell therapy called REGEND001 for people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. The therapy uses special lung cells to try to repair damaged tissue. In this phase 2 trial, 23 participants received either the cell therapy or a pla…

This study looked at whether hydroxychloroquine, a medicine used for malaria and autoimmune conditions, can help children with a rare genetic lung disease that affects the lungs' natural cleaning fluid. 25 children took the drug, and researchers checked if their need for extra ox…

This study looked at the long-term safety of a medicine called nintedanib in children and teenagers with a rare lung condition that causes scarring (fibrosing interstitial lung disease). All 54 participants took nintedanib capsules twice a day for at least 1.5 to 3 years. The goa…

This study tested whether giving oral care with maternal breast milk every 3 hours to preterm babies on breathing machines could improve outcomes. 70 infants born before 34 weeks were included. Researchers measured how long babies needed ventilation, hospital stay length, and rat…

This study tested a combination of plasma exchange, rituximab, and intravenous immunoglobulin in 82 people with a sudden, severe worsening of idiopathic pulmonary fibrosis (IPF). The goal was to see if this treatment could improve survival compared to usual care with antibiotics …

This study tested whether adding nintedanib (OFEV) to standard immunosuppressant therapy can improve symptoms in people with myositis-associated interstitial lung disease, a condition where lung tissue becomes scarred and stiff. 49 adults in the U.S. participated, receiving eithe…

This study tests an experimental oral drug, BI 1819479, in 322 adults with idiopathic pulmonary fibrosis (IPF). Participants receive one of three doses or a placebo for 6 to 12 months. The main goal is to see if the drug can slow the yearly decline in lung function, measured by b…

This study tested whether a new device called Mixsafe works as well as the standard Neopuff device for helping newborns breathe. 107 babies who needed breathing support at birth took part. The goal was to see if Mixsafe could be a safe and effective alternative for hospitals.

This study looked at 279 adults with worsening idiopathic pulmonary fibrosis (IPF), a serious lung disease. It compared taking two antifibrotic drugs together (pirfenidone and nintedanib) versus switching to the other single drug. The goal was to see which approach better slows l…

This Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care can improve lung function in 169 double lung transplant patients with chronic rejection. Participants inhaled the drug twice daily for 48 weeks. The main goal was to see if it slowed the de…

This study looked at 85 very premature babies (24-29 weeks) with breathing problems to compare two types of non-invasive breathing support: nasal CPAP and nasal IPPV. Both methods deliver surfactant (a lung treatment) without a breathing tube. The goal was to see which method red…

This study tested an inhaled medication called treprostinil in 5 people with sarcoidosis who also have lung scarring and high blood pressure in the lungs. The goal was to see if the drug could improve blood flow and heart function. Participants took the drug and were monitored wi…

This study monitored 425 Japanese patients with chronic fibrosing interstitial lung diseases that are getting worse over time (PF-ILD) who were prescribed Ofev capsules. Researchers tracked side effects, especially liver problems, to see how safe the drug is in everyday use. The …

This Phase 2 trial tested an experimental drug called BMS-986278 in 403 adults with pulmonary fibrosis, a condition that causes lung scarring and breathing difficulty. The study compared the drug to a placebo to see if it could improve lung function and was safe. Results will hel…

This completed phase 1 trial tested whether the steroid prednisolone can help people with persistent lung damage after a moderate to severe COVID-19 infection. One hundred adults with abnormal lung scans and reduced lung function were randomly assigned to receive either prednisol…

This study tested an experimental drug called MN-001 (tipelukast) in 15 people with moderate to severe idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Participants took either the drug or a placebo twice daily for six months, then everyone could take the drug for an…

This study tested a new medicine called BI 1015550 in 1178 adults with progressive fibrosing interstitial lung diseases (PF-ILDs), a condition where lung tissue scars and worsens over time. Participants took either a low or high dose of the drug or a placebo twice daily for at le…

This study tested a method called LISA (Less Invasive Surfactant Administration) in extremely preterm infants (22-25 weeks). Instead of inserting a breathing tube, doctors gave lung medication through a thin catheter while the baby continued on CPAP. The goal was to see if this a…

This study tested whether adding rituximab (a drug that calms certain immune cells) to standard mycophenolate mofetil treatment helps people with interstitial lung disease whose lungs are not responding to initial therapy. 122 adults with various ILD types received either rituxim…

This study looked at 100 premature babies (26-36 weeks) with respiratory distress syndrome who didn't improve with standard nasal CPAP. Researchers compared a newer, non-invasive high-frequency ventilation method (nHFOV) with traditional mechanical ventilation. The goal was to se…

This early study tested whether injecting human umbilical cord stem cells into the lungs is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Seventeen patients received different doses through a bronchoscope. The m…

This study looked at 180 premature babies born between 24 and 30 weeks to see if giving lung medication (surfactant) through a thin tube (LISA method) could reduce the need for a breathing tube in the first three days of life, compared to standard CPAP alone. The goal was to find…

This study tested whether giving small amounts of milk under the tongue (sublingual immunotherapy) could help children with cow milk allergy tolerate more milk. Fifty-one children aged 5 and older with confirmed IgE-mediated cow milk allergy participated. Over 12 months, research…

This study tested an experimental oral drug called INS018_055 in 71 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing hard. The main goal was to see if the drug is safe and tolerable over 12 weeks compared to a placebo. Resea…

This phase 2a trial tested a drug called PLN-74809 in 10 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. Participants took the drug or a placebo daily for 12 weeks. The study used a special PET/MRI scan to measure collagen (scar t…

This study looked at how an inhaled drug called treprostinil helps patients with pulmonary hypertension caused by interstitial lung disease. Researchers measured heart function and breathing efficiency during exercise after 3 months of treatment. The goal was to understand how th…

This early-stage trial tested the safety and tolerability of a new drug called BI 1015550 (Nerandomilast) in 15 people with idiopathic pulmonary fibrosis (IPF). Participants took either the drug or a placebo twice daily for up to 12 weeks. The study aimed to see if the drug is sa…

This completed Phase 2 trial tested whether inhaling a green tea extract called EGCG could help cancer patients with moderate-to-severe COVID-19 pneumonia. 111 participants received either EGCG mist or a placebo three times daily for 7 days. The study looked at lung CT scan impro…

This early-phase trial tested an experimental drug called PMG1015 in 29 people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal was to check the drug's safety and how the body processes it, not whether it works. Participants received either PMG1015…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with systemic sclerosis (scleroderma). Twenty-two adults with active arthritis took rituximab or a placebo, plus standard care. Researchers c…

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to MPO antibodies or vasculitis. Seven adults took the drug for a year, and researchers measured changes in lung functi…

This study tested a new way to deliver the drug everolimus directly to the lungs using tiny particles called liposomes. The goal was to treat chronic lung rejection (bronchiolitis obliterans syndrome) after a lung transplant. Researchers used human lung tissue and cells in the la…

This study tested an oral drug called GRI-0621 in 35 adults with idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring and breathing difficulty. Participants took either the drug or a placebo daily for 12 weeks. The main goals were to check safety and m…

This Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care helps single lung transplant patients with chronic lung rejection. 62 adults who had a single lung transplant at least a year earlier and had signs of chronic rejection took part. The study…

This large Phase 3 trial tested whether the drug BI 1015550 (nerandomilast) can help people with idiopathic pulmonary fibrosis (IPF), a serious lung disease that causes scarring and makes breathing hard. Over 1,100 adults aged 40 and older took either a low or high dose of the dr…

This study tested an inhaled drug called ARO-MMP7 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal was to check safety and how the body handles the drug. About 105 participants took p…

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This early-stage study tested a new drug called HuL001 in 24 people, including healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. The main goal was to check safety and how the body handles the drug. This is a first step to see if Hu…

This study tested a single dose of HLX6018, an experimental antibody, in 66 healthy adults to see if it is safe and how the body handles it. HLX6018 is designed to block a protein pathway involved in idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. Because thi…

This study tested whether a combination of the chemotherapy drug cyclophosphamide and the steroid prednisone could help people with scleroderma-related lung disease. Forty adults whose lung function had worsened in the past year received either the drug combo or a placebo plus pr…

This phase 3 trial tests whether nintedanib, a drug already used for lung scarring, can slow the decline in lung function in lung transplant recipients who develop bronchiolitis obliterans syndrome (BOS), a form of chronic rejection. 58 participants received either nintedanib or …

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study looked at whether lung MRI can diagnose bronchiolitis obliterans syndrome (BOS) after allogeneic stem cell transplant as well as chest CT scans. BOS is a serious lung complication that can occur after transplant, and early diagnosis is important. Researchers compared M…

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This study tested whether adding a tiny forceps biopsy to the standard needle biopsy during a lung ultrasound procedure helps doctors diagnose sarcoidosis more often. Fifty-five adults with enlarged lymph nodes in the chest took part. The goal was to see if the combined approach …

This study looked at whether a special ultrasound technique called fetal lung elastography can predict respiratory distress syndrome (RDS) in preterm babies. Researchers measured lung stiffness in 80 unborn babies between 24-33 weeks of pregnancy and compared those who later deve…

This study looked at three ways to take a small sample of lung tissue (biopsy) in 60 adults with interstitial lung diseases. The goal was to find which method gives the most accurate diagnosis and causes the fewest side effects. The methods tested were forceps biopsy, cryobiopsy …

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a new MRI technique that can take pictures of children's lungs without using radiation or injecting contrast dye. 72 children aged 6-16 had both a standard CT scan and this new MRI. The goal was to see if the MRI could produce clear images of the lungs, potentia…

This study tests a program called FLARE that teaches families how to protect children from the sun. It includes children ages 8 to 17 who have a parent who survived melanoma and who have had at least one sunburn in the past year. Families are randomly assigned to either the FLARE…

This study tested the drug letermovir to prevent CMV infection in 15 adults who had a lung transplant for idiopathic pulmonary fibrosis (IPF). Participants took letermovir daily for 6 or 12 months depending on their CMV risk. The goal was to see if the drug could prevent CMV infe…

This early-stage trial tested a new drug called rfhSP-D in 18 premature babies born before 30 weeks. The goal was to find the safest dose that might prevent chronic lung disease, a common complication in preemies. The drug was given along with standard care to babies on breathing…

This study tested whether a supplement made from bovine colostrum (the first milk from cows) can prevent repeated urinary tract infections (UTIs) in children. Sixty children with a history of recurrent UTIs took part. The goal was to see if this natural prebiotic could reduce the…

This study compared two groups of women having planned C-sections: one group had the surgery at 38 weeks after receiving two steroid shots (betamethasone) to speed up the baby's lung development, while the other group had the surgery at 39 weeks without steroids. The goal was to …

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This trial investigates whether adding high-flow nasal oxygen during exercise training can improve endurance and quality of life for people with chronic fibrotic interstitial lung disease (ILD). Participants undergo a 4-week pulmonary rehabilitation program, receiving either high…

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study tested two non-invasive breathing machines in 49 newborns (born at 33 weeks or later) with respiratory distress. One machine is the standard nasal CPAP, and the other is a newer device called nasal high frequency percussive ventilation. Researchers measured brain oxyge…

This study looked at whether a specific breathing exercise (forced expiration while lying on the side of the surgery) can shorten the time children need a chest tube after lung surgery. The tube drains fluid that builds up after the operation. The study involved 140 children aged…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This study looked at whether giving extra oxygen (40%) during exercise helps people with idiopathic pulmonary fibrosis (IPF) who do not have low oxygen at rest but do get low oxygen when active. Fifteen stable IPF patients completed exercise tests while breathing either oxygen or…

This study looked at whether breathing 60% oxygen during exercise helps people with idiopathic pulmonary fibrosis (IPF) who are taking nintedanib. 78 participants exercised on a bike or walked while getting either high oxygen or standard care. The goal was to see if they could ex…

This study followed 18 people in Spain with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who were taking nintedanib (OFEV) and had developed diarrhea. The goal was to see if the diarrhea could be controlled after 12 weeks while staying on the full dose. …

This study tested whether low-dose morphine can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Forty-four participants received either morphine or a placebo for two weeks, then switched after a week off. The goal was to see if…

This study tested whether a new formula made from hydrolyzed rice protein is safe for infants and young children with cow's milk protein allergy. 43 children with confirmed IgE-mediated allergy were given the formula in a controlled food challenge. The goal was to see if they cou…

This study tested whether using bandages printed with cartoon characters helps children feel less fear, stress, and pain during burn dressing changes. 42 children aged 6-11 with second-degree burns were randomly assigned to get either cartoon or plain bandages. The goal was to se…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…

This study looked at whether applying coconut oil or moisturizing lotion helps the skin of premature newborns. Researchers measured skin condition, moisture, pH, and vital signs like temperature and heart rate in 90 babies. The goal was to see if these simple moisturizers could i…

This study looked at whether taking fat from one part of the body and moving it to a breast that was damaged by radiation can help the tissue heal. Ten women who had radiation for breast cancer took part. The goal was to see if this fat transfer could make the skin softer and les…

This study tested freezing the nerves between the ribs during robot-assisted lung surgery to see if it reduces pain and the need for painkillers afterward. 33 adults having lung surgery were randomly assigned to get the nerve freeze or standard pain medicine. Researchers tracked …

This study looked at whether a pulmonary rehabilitation program helps people with Stage IV pulmonary sarcoidosis (advanced lung scarring) become more active in their daily lives. 38 adults took part and were followed for one year. The program aimed to improve exercise ability, re…

This study tested whether watching an underwater video through virtual reality goggles or on a screen could help children aged 7-12 feel less pain, fear, and distress while getting an IV. Sixty-six children were split into three groups: VR goggles, video screen, or standard care.…

This study tested two simple play activities—bubble breathing and tell-show-do (a storytelling technique)—to see if they could reduce anxiety in children aged 5-12 and their parents before elective surgery. 210 families participated, and their anxiety levels were measured before …

This study looked at two different chest therapy methods—Vojta reflex and lung squeezing—to help premature babies (28-36 weeks) with breathing problems. 90 babies were split into three groups: one got standard care, the others got standard care plus one of the two extra technique…

This study tested whether giving two medicines (atropine and fentanyl) before a less invasive breathing treatment helps preterm babies have fewer dangerous drops in heart rate and oxygen levels. Fifty-eight babies born at 29 weeks or later took part. The goal is to see if premedi…

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study tested whether adding functional electrical stimulation (FES) to cycling exercises helps people who survived severe COVID-19 recover more quickly. Twenty-two patients who had been on ventilators in the ICU took part in a 4-week rehab program. Half did cycling with FES,…

This study tested whether playing with an interactive toy or a robot during nebulized inhalation treatment reduces anxiety and fear in children aged 4-10 in the pediatric emergency department. 72 children were randomly assigned to use an interactive doll, a robot, or standard car…

This study looked at whether people with chronic lung disease who experience drops in oxygen during exercise can walk just as far without extra oxygen as with it. Forty patients completed a 6-minute walk test twice: once breathing normal air and once with low-flow oxygen. The goa…

This study tested whether playing special music (solfeggio frequencies or Turkish classical tunes) during allergy skin tests could lower pain in children and anxiety in their parents. 120 children aged 2 to 17 took part. Parents reported their anxiety before and after the test, a…

This study tested a drug called orvepitant to see if it can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 80 adults with IPF and persistent cough took either orvepitant or a placebo in two separate periods, and researche…

This study tested a new automatic oxygen device in 29 people with fibrotic lung disease (scarred lungs). The device automatically adjusts oxygen flow during walking to keep oxygen levels steady. The goal was to see if it reduces breathlessness compared to the usual fixed oxygen d…

This study tested whether acupressure (gentle massage on specific points) could help premature babies with lung fluid buildup. 42 infants born at 32 weeks or earlier received either acupressure plus routine chest therapy or routine care alone. Researchers tracked how often suctio…

This study looked at 60 premature newborns (born between 28-37 weeks) in the neonatal intensive care unit who had breathing problems or were on a ventilator. Researchers compared different chest physiotherapy methods and positions to see which worked best for clearing the lungs. …

This study tested whether using a Lung Boost breathing trainer could improve lung function and reduce fatigue in people with interstitial lung disease. Forty women with the condition used the device three times a week for eight weeks. Researchers measured their lung capacity, oxy…

This study follows 31 people with progressive fibrosing interstitial lung disease (PF-ILD) for one year. Researchers compare imaging scans (CT and MRI) with standard breathing tests to see which method best tracks lung damage over time. The goal is to find better ways to measure …

This study follows 1500 adults with interstitial lung disease to understand how the condition changes over time. Researchers will track symptoms, lung function, and treatments used. The goal is to build a detailed picture of the disease's course and improve future care.

This study followed 72 adults with pulmonary hypertension caused by chronic lung diseases, like interstitial lung disease, who were treated with inhaled iloprost in routine care. Researchers tracked changes in their risk levels over time using a standard scoring model. The goal w…

This observational study will look at 80 children aged 8-14 to see if regularly playing wind instruments like the flute or melodica changes their chest movement, posture, breathing rate, and physical capacity. Half the kids will be wind instrument players, and the other half will…

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study looked at ways to screen for pulmonary hypertension (high blood pressure in the lungs) in people who already have interstitial lung disease. The goal was to find this complication earlier. 314 adults with various types of lung disease took part in the screening tests.

This study looked at whether certain genes make people who are regularly around pigeons more likely to develop a type of lung disease called hypersensitivity pneumonitis. Researchers analyzed the DNA of 475 pigeon fanciers to find genetic markers linked to lung scarring. The goal…

This study looked at whether a lung ultrasound score can help doctors decide when to safely remove a breathing tube from newborn babies with breathing problems. 71 infants in the NICU had an ultrasound before and after their breathing tube was removed. The goal was to see if the …

This study looked at how a new drug called HEC585 interacts with two existing medicines for idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Thirty-three healthy adults took part to measure drug levels and safety. The goal was to see if combining these drugs cause…

This study looked at 136 premature babies who needed breathing help. Researchers tracked how long they needed support and checked for lung problems. The goal was to learn more about different non-invasive breathing methods, not to test a new treatment.

This study looked at whether chest ultrasound can predict which premature babies (born before 34 weeks) will need surfactant—a substance that helps their immature lungs work better. Doctors currently decide based on oxygen levels, which can delay treatment. Researchers performed …

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study looked at 86 ICU patients with a lung condition called interstitial syndrome. Researchers compared a lung ultrasound score with a standard blood oxygen test to see if the ultrasound could reliably measure how severe the condition was. They repeated both tests at the st…

This study compared two commercially available devices that measure how well the lungs transfer nitric oxide and carbon monoxide. Nine adults with systemic sclerosis and related lung disease took part. Each person was tested with both devices in random order to see if the results…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study looked at 93 people with lung disease who get short of breath when active. Participants did two 6-minute walk tests: one at their fastest pace and one at their normal walking speed. The goal was to see if the normal-speed test gives a more accurate picture of when they…

This study looked at how two different breathing devices affect the lungs of extremely low birth weight babies. Researchers compared a high-flow nasal cannula to nasal CPAP in 80 stable premature infants. They measured lung function using a special imaging technique to see which …

This study tested whether a new type of PET scan can measure how the supplement EGCG (found in green tea) affects collagen buildup in the lungs of people with idiopathic pulmonary fibrosis (IPF). Twelve participants who were already in a larger EGCG study received an injection of…

This completed study looked at levels of a specific antibody (IgG4) to cow's milk and egg in 135 children, both with and without allergies. Researchers wanted to see if these levels could help tell which children have outgrown their allergy. The study involved a single blood draw…

This completed study in France tracked over 10,000 people with idiopathic pulmonary fibrosis to see how long they continued taking antifibrotic drugs (nintedanib or pirfenidone). The goal was to measure the percentage still on treatment after 30 months and identify factors linked…

This study tested an online training program called GRIN, designed to help community health workers better support the dental health of high-risk children and teens. 455 health workers took part, completing surveys on their knowledge, attitudes, and confidence before and after th…

This study looked at 90 children with cow's milk allergy to see if a special formula (Nutramigen LGG) changes how genes work. Researchers measured DNA changes over 12 months. The goal was to understand how the formula helps kids outgrow the allergy, not to test a new treatment.

This study looked at 80 people who had a lung transplant to see if measuring neural respiratory drive (a breathing signal) and a protein called Pro-BNP could predict when their condition might get worse. The goal is to catch problems like infection or rejection early so treatment…

This study followed 51 people with idiopathic pulmonary fibrosis (IPF) for 6 months to understand how their shortness of breath changes over time. Researchers measured both the physical sensation and the emotional impact of breathlessness, and looked at how these relate to lung f…

This study tested whether a special MRI technique can measure lung stiffness in people with scleroderma, a disease that often causes lung scarring. Researchers enrolled 24 adults and compared MRI results to standard lung function tests. The goal was to see if MRI could offer a sa…

This study tested a new device called Neola® that monitors the lungs of newborn babies. Ten preterm and term infants were enrolled to see if the device is safe and works well. The main goal was to check for any skin reactions or other side effects.

This study uses a special MRI technique with inhaled helium-3 gas to measure how fast air moves through the windpipe and lungs. Researchers will compare airflow in healthy volunteers and people with COPD or constrictive bronchitis. The goal is to gather real-world data to improve…

This study looked at 271 children in China with a rare lung condition called childhood interstitial lung disease (chILD). Researchers collected medical information and genetic samples to find out what causes the disease. The goal was to create a database and biobank to help docto…

This completed study from the University of Virginia looked at whether having a hiatal hernia (a stomach issue) is linked to early, undetected lung scarring. Researchers collected blood and lung fluid samples from 14 adults before surgery to measure signs of lung injury. The goal…

This study looked at how changing the speed at which a ventilator reaches its target pressure affects breathing in 17 newborns on breathing support. The researchers tested different settings and measured changes in airway pressure and gas exchange. The goal was to find out if thi…

This study tested three different oximeters (Masimo, Nellcor, Nonin) at various oxygen targets in 40 patients with and without COPD. The goal was to see how the choice of oximeter and target affects the amount of oxygen needed. Results could help guide safer oxygen therapy.

This study looked at 127 pregnant women who received a steroid called betamethasone to help prevent lung problems in their premature babies. Researchers measured how much of the drug reached the baby and whether it reduced the risk or severity of hyaline membrane disease, a serio…

This study tested a simple questionnaire to help match newly diagnosed idiopathic pulmonary fibrosis (IPF) patients to the right level of palliative care. Researchers asked 30 patients a few questions to see if the tool could predict their needs as accurately as a doctor's judgme…

This study looked at 21 adults with idiopathic pulmonary fibrosis (IPF) to see how a simple arm test (the 6-minute pegboard and ring test) relates to their exercise ability, fatigue, daily activities, and quality of life. Participants performed several physical tests, including w…

This University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…

This study tested whether a simple video call system on a tablet could help doctors remotely assess children with breathing problems while they were being transported in an ambulance. Researchers worked with 20 children who were stable enough for transport and compared the remote…

This early-stage study tested the safety and how the body handles an inhaled drug called CHF10073 in 155 healthy volunteers. The drug is being developed for pulmonary fibrosis, a serious lung-scarring condition. The trial looked at different single and multiple doses, and also ch…

This study tested a new way to measure pain in preterm infants during a procedure called LISA, where surfactant is given to help them breathe. Researchers used skin conductance, which tracks nerve signals, and compared it to a standard pain scale. The goal was to see if this meth…

This study tested a special MRI technique using a harmless gas to see how well it can show changes in the lungs of people with interstitial lung disease. Researchers worked with 46 volunteers to find the best way to use this scan. The goal is to create a standard method that doct…

This study tested a new way to find early signs of lung damage in people with COPD or ILD by analyzing carbon dioxide (CO2) in their breath in real time. Researchers aimed to detect changes before standard lung function tests show any problems. The study included 40 adults, inclu…

This completed study from Alexandria University looked at 40 adults with lung sarcoidosis who were receiving or about to start immunosuppressive therapy. Researchers tracked them for 12 months to see if any developed lymphoma, confirmed by lymph node biopsy. The goal was to under…

This study followed 600 lung transplant recipients at the University of Pittsburgh to see how common viral and bacterial infections are and how they affect long-term health. Researchers focused on whether a specific infection (C. pneumoniae) is linked to a condition called bronch…

This pilot study tested two ways to help premature babies breathe right after birth: volume-targeted ventilation (giving a set amount of air) versus pressure-targeted ventilation (giving air at a set pressure). The study included 52 infants born between 23 and 28 weeks of pregnan…

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This study tested a special MRI technique called Ultra Short Echo Time (UTE) to see if it can take clearer pictures of the lungs than traditional MRI. Researchers collected images and health information from people with and without lung disease to help doctors better understand l…

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This study tested whether having a dietitian help patients with lung disease order meals during a hospital stay could improve their nutrition and reduce the chance of being readmitted after discharge. 41 patients at nutritional risk took part. Researchers measured daily food inta…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This study tested a new drug called 9MW3811 for the first time in humans. The main goal was to check if it is safe and how well it is tolerated in 32 healthy adults aged 18 to 55. Researchers gave a single dose and monitored for side effects, measuring how the drug moves through …

This Pfizer study tested whether wearable activity monitors (like a smartwatch) can accurately measure walking, running, and sleep in healthy children aged 3 to 17. Eighty-seven kids wore the devices during lab activities and at home for two weeks. The goal was to see if these to…

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This study looked at 111 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. Researchers used MRI scans to check for iron deposits in the cerebellum, a part of the brain that controls balance and coordination. The goal was to learn where …

This study looked at whether a device that delivers rapid puffs of air (intrapulmonary percussive ventilation) can help inhaled medication reach scarred lung areas in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a radioactive tracer with and without …

This study tested whether an AI tool called Lunit INSIGHT CXR helps healthcare professionals read chest X-rays more accurately and quickly. Thirty doctors and radiographers reviewed 500 past chest X-rays from two UK hospitals, once with and once without AI help. The goal was to s…

This study tested a new self-administered questionnaire called DYSLIM to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, cystic fibrosis, and pulmonary hypertension. Researchers enrolled 199 participants to check if …

This study looked at 34 breastfed infants under 6 months old with cow's milk protein allergy. Researchers wanted to see if a cow's milk elimination diet for mothers and babies could improve symptoms, growth, and gut immune markers like MUC2 and sIgA. They collected stool samples …

This study looked back at the medical records of 67 children treated for anaphylaxis in a Turkish emergency department over 10 years. Researchers wanted to know how long kids were observed and how often a second wave of symptoms (biphasic reaction) occurred. They also looked for …

This study followed 397 premature babies (under 32 weeks) who were given non-invasive breathing support. Researchers looked for early clues, like how much extra oxygen the babies needed, to predict which ones would later need a breathing tube. The goal is to help doctors decide e…

This study involved 1304 adults with rheumatoid arthritis who had at least two risk factors for interstitial lung disease (ILD), such as being male, a smoker, or over 60. Researchers used CT scans to develop a prediction model that helps doctors decide who should be screened for …

This study followed 158 adults with chronic fibrosing interstitial lung disease (a type of progressive lung scarring) who were starting treatment with nintedanib. Researchers wanted to see if changes in lung function (measured by forced vital capacity) over 52 weeks were linked t…

This study followed 38 adults who survived severe breathing failure from the 2009 H1N1 flu. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months af…

This study tested a new MRI technique using inhaled hyperpolarized xenon gas to detect early signs of bronchiolitis obliterans syndrome (BOS), a common form of chronic rejection after lung transplant. Only 3 participants were involved, and the goal was to see if the imaging could…

This completed study looked at 60 people with idiopathic pulmonary fibrosis (IPF) to see how common muscle loss (sarcopenia) is and how it affects their quality of life and disease progression. Researchers measured muscle strength, walking speed, lung function, and used a questio…

This completed study looked at 143 people with two types of lung scarring diseases (IPF and hypersensitivity pneumonitis). Researchers compared three different scoring systems (GAP, ILD-GAP, and CPI) to see which one best predicts how long patients might live. The goal was to fin…