New MRI breath test could spot lung transplant rejection earlier
NCT ID NCT03603899
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested a new MRI technique using inhaled hyperpolarized xenon gas to detect early signs of bronchiolitis obliterans syndrome (BOS), a common form of chronic rejection after lung transplant. Only 3 participants were involved, and the goal was to see if the imaging could spot ventilation defects. The research is very early and focused on improving diagnosis, not treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hyperpolarized 129Xenon gas
- What this could lead to
- If successful, this imaging method could allow earlier detection of bronchiolitis obliterans in lung transplant patients, potentially improving outcomes through timely intervention.
- What could go wrong
- This is a very small, early-phase study (only 3 participants) focused on developing imaging techniques, not testing a treatment. The method may not prove sensitive enough or may not work in larger, more diverse groups.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can lung MRI replace CT scans for detecting a serious Post-Transplant lung condition?
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