Children's Hospital Medical Center, Cincinnati

This study tests whether a simple xylitol wipe applied inside the mouth twice a day can reduce dangerous bloodstream infections in children receiving stem cell transplants. These infections often start from mouth bacteria and can be life-threatening. The trial involves 419 childr…

This early-stage trial tests a new gene therapy for hereditary pulmonary alveolar proteinosis (hPAP), a rare lung disease. Only 3 people will receive a transplant of their own lung cells that have been genetically corrected. The main goal is to check safety and see if the treatme…

This study tests whether specially grown immune cells from a donor can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard medicines. The approach aims to boost the patient's weakened…

This study tests a new way to start hydroxyurea for people with sickle cell anemia. Instead of dosing based only on weight, the dose will be tailored to how each person absorbs the drug. The goal is to reduce organ damage and improve long-term health. About 50 participants with s…

This study tests a new way to treat acute myeloid leukemia (AML) that has come back or not responded to standard therapy. Researchers take immune cells from a half-matched donor, boost them in the lab, and give them to the patient. The goal is to see if this treatment is safe and…

This early study tests whether giving a bone-strengthening drug called zoledronate soon after a stem cell transplant can safely prevent bone disease and fractures in children. About 20 children aged 5 to 18 who are at high risk for bone problems will receive the drug. The main go…

This study tests a drug called mirdametinib in people aged 2 and older with certain rare immune cell diseases (like Langerhans cell histiocytosis). The goal is to see if it works better and causes fewer side effects than current treatments. About 40 participants will take the dru…

This study tests a procedure called FETO (fetal endoscopic tracheal occlusion) in pregnant women whose babies have a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm has a hole and the lungs are too small. The surgery places a tiny balloon in the baby's w…

This study tests a stem cell transplant method for people with Fanconi anemia who don't have a perfectly matched donor. The goal is to see if using lower doses of certain chemotherapy drugs can reduce serious side effects while still helping the transplant succeed. About 70 parti…

This study tests whether romiplostim, a drug that helps the body make more platelets, can prevent dangerously low platelet counts caused by chemotherapy in children and young adults with newly diagnosed Ewing sarcoma. About 26 participants will receive romiplostim alongside their…

This study tests whether specially trained immune cells from a healthy donor can safely treat viral infections in people whose immune systems are weak, such as after a stem cell transplant. The cells are grown in a lab and then given to the patient. The main goals are to see if t…

This early-stage study tests whether quercetin, a natural antioxidant found in foods, is safe and can reduce inflammation in male patients with XIAP deficiency, a rare genetic immune disorder. The trial will enroll 12 participants aged 2 and older. Researchers will monitor side e…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online CBT alone. About 400 kids with frequent migraines will participate. The goal is to see which approach reduces headache …

This study tests a nurse-led mind-body program to reduce headache days in children with migraine. Researchers will compare different combinations of three treatment components to find the best approach. The study aims to enroll 260 children aged 10-17 who have frequent migraines.…

This study compares two group interventions for middle-school children with autism. One program teaches social skills, the other focuses on organization and planning. 224 kids will be randomly assigned to one of the two programs. The goal is to see which approach better improves …

This study tests a virtual reality driving program for teens aged 16-19 with ADHD who have a driver's license. The training focuses on reducing how often they look away from the road, which is a common cause of crashes. Participants will complete simulated drives while doing task…

This study looks at how the brain controls movement in children with dystonia, a condition that causes muscle spasms and twisting. Researchers will use noninvasive tests like EEG to measure brain activity in 75 children, both with and without deep brain stimulation devices. The g…

This study tests new ways to measure lung changes in people with cystic fibrosis (CF) aged 12 to 21. Researchers will use special MRI scans with a breathable gas (Xenon) and a lung function test called LCI to see what happens when patients stop and restart their daily airway clea…

This study compares two telehealth programs for autistic adolescents in their last two years of high school. One program focuses on daily living skills like cooking and managing money, while the other focuses on social skills. Researchers want to see which program better helps te…

This study is testing a new type of MRI that uses a special gas called xenon to take detailed pictures of lung function. Researchers want to see if this method works well in healthy people and those with lung diseases. About 300 children and adults ages 6 and older will participa…

This study is a registry that collects information from people with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system becomes overactive and damages the body. Researchers will track how the disease develops, what treatments are used, and how patie…

This study creates a repository of blood, tissue, and other samples from up to 5,000 children and adults with or at risk for pediatric heart disease. Researchers will use these samples to study how genes and health outcomes are linked. The goal is to support future research, not …

This study is testing whether a shorter, abbreviated MRI scan can detect signs of Crohn's disease as well as the longer standard scan. Researchers will compare the two scans in 300 children and adults with Crohn's. Participants will also share which scan they prefer. The goal is …

This study uses MRI scans to learn how the lungs grow and develop in premature babies, especially those with a breathing problem called BPD. Researchers will look at lung structure and function in about 160 infants during quiet breathing. The goal is to better understand prematur…

This study aims to find out if eosinophilic gastritis, a condition where certain white blood cells build up in the stomach lining, leads to problems with how the stomach empties food. Researchers will use a special oatmeal meal with a tiny amount of radioactive material to track …

This study is testing a special MRI technique that uses xenon gas to take detailed pictures of lung function. It involves 100 healthy adults who can hold their breath for 16 seconds. The goal is to improve how we see and measure lung activity, not to treat any disease.

This study looks at how the body handles venetoclax when the tablet is crushed and mixed into a liquid. It includes children and young adults up to age 39 with blood cancers like leukemia or lymphoma who already take venetoclax this way. The goal is to measure drug levels in the …

This study looks at whether infants and young children with sickle cell disease (SCD) get enough protection from the standard measles vaccine. Researchers will measure antibody levels in 130 children with SCD after they receive their routine measles shots. The goal is to understa…

This study is for people with eosinophilic gastrointestinal disease, eosinophilic inflammatory disease, or food allergy, as well as their family members and healthy volunteers. Researchers want to learn how eosinophils (a type of white blood cell) grow, move, and cause inflammati…

This study aims to understand which brain areas are active when people with autism or Fragile X syndrome try to hear speech in background noise. Researchers will compare brain activity and hearing tests among 60 participants, including those with autism, Fragile X, and typical de…

This study looks at whether playing special sounds through headphones can help children aged 5-10 with Fragile X syndrome or autism. The sounds aim to calm overactive brain activity and improve learning. Researchers will measure brain waves and learning ability to see if the appr…

This study collects blood, tissue, and medical information from up to 1,000 people with RASopathies—a group of genetic conditions that affect development and raise cancer risk. Researchers will store these samples and data in a database to help future studies. No treatments or di…

This study aims to develop and validate a urine drug test that can detect thebaine, a substance found in poppy seeds. Researchers will enroll 20 healthy adults aged 18-65 to provide urine samples after eating poppy seed products. The goal is to create a more accurate screening me…