Children's Hospital Medical Center, Cincinnati

This study tests the safety and effectiveness of hydroxyurea, a medicine that helps manage sickle cell disease, in 811 children aged 3 to 10 in Africa. The goal is to see if the drug can reduce complications and make it more widely available. Participants take hydroxyurea long-te…

This study looks at whether giving hydroxyurea based on a child's unique body chemistry can lower the need for blood transfusions in children with sickle cell anemia. About 100 children aged 1 to 10 years will receive the drug and be monitored. The goal is to make treatment more …

This study tests whether giving monthly grocery gift cards to low-income families for one year after their child's hospital discharge reduces food insecurity and the need to return to the hospital. About 400 families with Medicaid insurance will take part. Families in the interve…

This study aims to understand how cystic fibrosis (CF) damages small blood vessels in the lungs. Researchers will use imaging to measure blood vessel changes in 86 people with CF, ages 5 to 21, and compare them to lung function. The goal is to learn more about the disease, not to…

This study looks at how single doses of baclofen, roflumilast, and memantine affect brain activity and behavior in 45 adults with Fragile X Syndrome. Participants take each drug or a placebo on separate days, and researchers measure changes in brain waves and clinical symptoms. T…

This study creates a registry for people with TFE renal cell carcinoma, a rare kidney cancer. Researchers will collect medical information, tumor samples, and images from up to 28 participants. The goal is to better understand the disease and help develop new treatments in the fu…

This study uses a new, contrast-free MRI technique to measure blood flow in the lungs of 26 children with cystic fibrosis (ages 6-21). Researchers want to see if blood vessel damage happens before or alongside the more commonly measured airway damage. The goal is to better unders…

This study tests whether a special communication technology can help deaf or hard-of-hearing children improve their language skills. About 114 children aged 3 to 10 with moderate to profound hearing loss and language delays will be randomly assigned to use the technology or conti…

This study aims to make a special type of MRI (using xenon gas) better at detecting changes in lung disease called interstitial lung disease. Researchers will test the method in 78 adults across multiple hospitals to ensure it is reliable and can be used widely. The goal is to he…