Inhaled cyclosporine shows promise for lung transplant rejection
NCT ID NCT03657342
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care helps single lung transplant patients with chronic lung rejection. 62 adults who had a single lung transplant at least a year earlier and had signs of chronic rejection took part. The study measured changes in lung function over 48 weeks to see if the drug could slow decline.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liposomal cyclosporine A (inhaled)
What this could lead to
If successful, this could offer a new add-on treatment to slow lung function decline in transplant patients with chronic rejection.
What could go wrong
This is a small Phase 3 trial (62 participants) and results may not apply to all patients. Inhaled cyclosporine may cause side effects like cough or throat irritation.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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108
Philadelphia, Pennsylvania, 19104, United States
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110
St Louis, Missouri, 63110, United States
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113
New York, New York, 22042, United States
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119
Columbus, Ohio, 43210, United States
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Banner Health
Phoenix, Arizona, 85013, United States
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Baylor St. Luke's Medical Center
Houston, Texas, 77030, United States
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Baylor University Medical Center
Dallas, Texas, 75246, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Complexo Hospitalario de A Coruna
A Coruña, Spain
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Hannover Medical School - MHH Klinik für Pneumologie
Hanover, Germany
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Hospital Marques de Valdecilla
Santander, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Puerta de Hierro
Madrid, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14004, Spain
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Hospital Universitario y Politécnico La Fe
Valencia, Spain
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Hôpitaux Universitaires de Strasbourg
Strasbourg, France
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Indiana University Health Methodist Hospital
Indianapolis, Indiana, 46202, United States
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Johns Hopkins University Hospital
Baltimore, Maryland, 21287, United States
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LMU Klinikum Großhadern
Munich, Germany
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Mayo Clinic Jacksonville
Jacksonville, Florida, 32224, United States
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Norton Thoracic Institute at St. Joseph's Hospital
Phoenix, Arizona, 85013, United States
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Rabin Medical Center
Petah Tikva, Israel
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Royal Papworth Hospital NHS Foundation Trust
Cambridge, United Kingdom
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Stanford University Hospital
Palo Alto, California, 94305, United States
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Temple University Hospital
Philadelphia, Pennsylvania, 19140, United States
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UC San Francisco
San Francisco, California, 94143, United States
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UCLA Medical Center
Los Angeles, California, 90095, United States
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Universitair Ziekenhuis Leuven
Leuven, 3000, Belgium
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University Hospital of South Manchester NHS Foundation Trust
Manchester, United Kingdom
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University of Florida Medical Center
Gainesville, Florida, 32608, United States
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University of Kentucky Albert B. Chandler Hospital
Lexington, Kentucky, 40508, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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University of South Florida
Tampa, Florida, 33606, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States