Chronic transplant rejection

This early-stage trial tests whether giving a special mix of blood cells after an organ transplant can help the body accept the new organ without needing lifelong anti-rejection drugs. About 10 children and adults receiving kidney, lung, or intestinal transplants will get the cel…

This study tests if giving blood thinners (aspirin or clopidogrel) soon after a heart transplant can prevent a common complication called cardiac allograft vasculopathy, which narrows the heart's arteries. About 135 adult heart transplant recipients will be randomly assigned to r…

This study tests a treatment called extracorporeal phototherapy (ECP) for people whose kidney transplants are failing due to chronic antibody-mediated rejection. ECP involves taking a patient's blood cells, treating them with a light-activated drug and UVA light, then returning t…

This study offers a special way to prepare donor stem cells for children and teens under 22 who need a transplant but lack a perfectly matched sibling donor. The method uses the CliniMACS® system to remove certain immune cells, which may help reduce the risk of graft-versus-host …

This study tests whether a non-invasive PET scan can safely replace the standard invasive coronary angiography for monitoring heart transplant patients. About 576 participants who had a heart transplant 2-10 years ago will be randomly assigned to annual surveillance with either P…

This study looks at 60 people getting a stem cell transplant to see if their autonomic nervous system (which controls things like heart rate and sweating) can help predict a serious complication called graft-versus-host disease (GvHD). Participants will have simple nerve tests be…

This study will check how common frailty is in 80 people who have received a kidney transplant. Researchers will use simple tests like walking speed and grip strength to measure frailty. They want to see if frailty is linked to long-term kidney function problems.