Heart transplant patients may soon skip invasive artery checks with new PET scan study

NCT ID NCT06089486

Recruiting now Diagnosis Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a non-invasive PET scan can safely replace the standard invasive coronary angiography for monitoring heart transplant patients. About 576 participants who had a heart transplant 2-10 years ago will be randomly assigned to annual surveillance with either PET or angiography. The goal is to see if PET is just as good at detecting dangerous artery narrowing without the risks of an invasive procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If PET proves as effective as invasive angiography, heart transplant patients could avoid repeated invasive procedures for routine monitoring.
What could go wrong: This is a non-inferiority trial, so PET might not be as accurate as angiography. The study is observational in design, not testing a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ALLOGRAFT VASCULOPATHY

Contacts and locations

Locations

Mazankowski Alberta Heart Institute
NOT_YET_RECRUITING

Edmonton, Alberta, Canada
Montreal Heart Institute
NOT_YET_RECRUITING

Montreal, Quebec, Canada
Toronto-General Hospital - University Health Network
NOT_YET_RECRUITING

Toronto, Ontario, Canada
University of Calgary
NOT_YET_RECRUITING

Calgary, Alberta, Canada
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada

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