Chronic transplant rejection
MONDO:1010188An insidious form of transplant rejection that leads to graft destruction over months to years after tissue transplantation. Chronic rejection can be mediated by either humoral or cellular mechanisms linked to memory/plasma cells and antibodies. The presence of tertiary lymphoid organs in the graft is a characteristic of this form of rejection.
23 clinical trials for this condition and its sub-types.
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Heart transplant patients get new weapon against hidden artery damage
Disease control CompletedThis study tested the drug alirocumab in 114 heart transplant recipients to see if it safely reduces plaque buildup in the new heart's arteries. The drug targets a protein called PCSK9 to lower harmful cholesterol. Researchers measured changes in artery plaque using ultrasound at…
Phase: PHASE2 • Sponsor: Stanford University • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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New drug cocktail aims to stop kidney rejection in transplant patients
Disease control CompletedThis study tested whether a drug called bortezomib, given with steroids, plasma exchange, and immunoglobulins, can treat chronic antibody-mediated rejection in kidney transplant recipients. The trial included 60 adults who had a kidney transplant and developed donor-specific anti…
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Inhaled cyclosporine aims to halt lung transplant rejection
Disease control CompletedThis Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care can improve lung function in 169 double lung transplant patients with chronic rejection. Participants inhaled the drug twice daily for 48 weeks. The main goal was to see if it slowed the de…
Phase: PHASE3 • Sponsor: Zambon SpA • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Inhaled cyclosporine shows promise for lung transplant rejection
Disease control CompletedThis Phase 3 trial tested whether adding inhaled liposomal cyclosporine A to standard care helps single lung transplant patients with chronic lung rejection. 62 adults who had a single lung transplant at least a year earlier and had signs of chronic rejection took part. The study…
Phase: PHASE3 • Sponsor: Zambon SpA • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Can boosting hemoglobin help kidney transplant patients feel better and protect their kidneys?
Disease control CompletedThis study looked at whether raising hemoglobin levels with a drug called epoetin (Neorecormon) could improve quality of life and slow kidney function decline in people who had a kidney transplant and now have chronic graft dysfunction. About 128 adults who had a transplant 1 to …
Phase: PHASE4 • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New drug cocktail aims to stop kidney rejection
Disease control CompletedThis study tested whether adding the drug bortezomib to a standard treatment (rituximab, plasma exchange, and IVIG) helps control antibody-mediated rejection in kidney transplant patients. Twenty participants were enrolled, and researchers measured kidney function and rejection m…
Phase: NA • Sponsor: Shahid Beheshti University of Medical Sciences • Aim: Disease control
Last updated Jun 26, 2026 15:09 UTC
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Scientists probe immune cells to predict transplant rejection
Knowledge-focused CompletedThis completed study looked at 116 kidney transplant patients to understand how B cells (a type of immune cell) behave in those who develop donor-specific antibodies or chronic rejection. Researchers analyzed blood samples to find patterns that could serve as early warning signs.…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Lung transplant infection study aims to improve Long-Term survival
Knowledge-focused CompletedThis study followed 600 lung transplant recipients at the University of Pittsburgh to see how common viral and bacterial infections are and how they affect long-term health. Researchers focused on whether a specific infection (C. pneumoniae) is linked to a condition called bronch…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC