Chronic transplant rejection

This study tests whether adding Thymoglobulin to standard anti-rejection drugs helps prevent complications after a first heart transplant. About 60 adults will receive either standard therapy alone or standard therapy plus five days of Thymoglobulin. Researchers will check for si…

This phase 2 trial tests whether adding belumosudil (Rezurock) to standard care can prevent scarring in new kidney transplants. About 40 adults receiving their first or second kidney will be randomly assigned to get the drug or a placebo for a year. The study tracks serious side …

This study tests whether a blood test measuring donor-derived cell-free DNA can reliably detect kidney transplant rejection. Researchers will compare the test results with kidney biopsy findings in 5,000 transplant recipients across multiple countries. The goal is to see if this …

This study is developing an artificial intelligence (AI) system to analyze kidney biopsy images from transplant patients. The goal is to see if AI can accurately tell apart different types of rejection, measure how much damage the kidney has, and predict if rejection might come b…

This study tests better ways to detect early artery narrowing in new hearts after transplant, a condition called cardiac allograft vasculopathy (CAV). About 80 adult heart transplant patients will be followed within their first three months to compare advanced imaging and blood t…

This study follows about 4,200 lung transplant recipients in France to understand why some people develop serious complications like chronic lung allograft dysfunction (CLAD). Researchers will collect routine health data, lung function tests, and blood samples to build a model th…

This study looks at gene activity in blood cells from 30 kidney or lung transplant patients who have chronic rejection. Researchers want to find out why some patients improve with a treatment called extracorporeal photoapheresis (ECP) while others do not. The goal is to better un…

This study aimed to see if a simple blood test could find blockages in the small blood vessels of the heart in people who have had a heart transplant. Participants would have had blood draws every three months for a year, and their medical records would have been reviewed for thr…