Chronic transplant rejection
MONDO:1010188An insidious form of transplant rejection that leads to graft destruction over months to years after tissue transplantation. Chronic rejection can be mediated by either humoral or cellular mechanisms linked to memory/plasma cells and antibodies. The presence of tertiary lymphoid organs in the graft is a characteristic of this form of rejection.
23 clinical trials for this condition and its sub-types.
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New drug aims to stop kidney transplant rejection
Disease control Not yet recruitingThis study tests a new medicine called CID-103 in adults whose kidney transplants are being rejected by their immune system (antibody-mediated rejection). The trial has two parts: first, to find a safe dose, and second, to see if the drug can stop the rejection. About 58 people w…
Phase: PHASE1, PHASE2 • Sponsor: CASI pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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Stem cell therapy fails to improve kidney rejection, raises safety flags
Disease control Not yet recruitingThis study tested whether a person's own stem cells (mesenchymal stem cells) could help treat chronic active antibody-mediated rejection in kidney transplant recipients. Only 3 patients were enrolled before the study was stopped early due to serious side effects. The treatment di…
Phase: NA • Sponsor: Shahid Beheshti University of Medical Sciences • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC