Cirrhosis of liver

This study tests a drug called hydronidone in 300 adults with liver scarring (fibrosis or cirrhosis) from chronic hepatitis B. Participants take the drug three times daily for 28 days to see if it is safe. The main goal is to track any side effects.

This trial asks whether giving vitamin D3 to people with low vitamin D before a liver transplant can reduce bacterial infections in the first three months after surgery. Adults with cirrhosis and vitamin D deficiency who are scheduled for a liver transplant will receive either we…

This early-phase study tested whether adding fenofibrate to standard treatment (ursodeoxycholic acid) helps people newly diagnosed with primary biliary cholangitis, a chronic liver disease. Thirty adults participated to see if the combination could normalize liver enzyme levels a…

This pilot study tests whether a coordinated care program can help people with alcohol-related liver disease access addiction and mental health services more easily. The program brings together liver specialists, addiction medicine, and psychiatry to streamline referrals and care…

This trial investigates whether two common osteoporosis medications, denosumab and alendronate, can reduce liver fat and scarring in postmenopausal women who also have nonalcoholic fatty liver disease (NAFLD). The study will compare changes in liver fat and stiffness over 12 mont…

This study tested whether adding bezafibrate to the standard drug obeticholic acid helps people with primary biliary cholangitis, a rare liver disease. 72 adults took part, and researchers measured changes in a key liver enzyme over 12 weeks. The goal is to see if the combination…

This study tests whether elafibranor, a daily pill, can normalize alkaline phosphatase (ALP) levels in adults with primary biliary cholangitis (PBC) who did not respond well to or cannot take standard treatment. About 69 participants will receive either elafibranor or a placebo f…

This study tests an experimental drug called AZD2389 in people with liver fibrosis (scarring) and compensated cirrhosis (early-stage liver damage). The goal is to check the drug's safety and how the body handles it. About 40 adults with liver disease will receive either AZD2389 o…

This study tested whether low doses of the hormone drug danazol can slow the shortening of telomeres—the protective caps on DNA—in people with telomere diseases. These conditions can cause bone marrow failure, lung scarring, and liver damage. Eighteen participants took danazol fo…

This early-stage trial tested a new drug, LY3849891, in 115 people with fatty liver disease who carry a specific gene variant (PNPLA3 I148M). The main goal was to check safety and how the body processes the drug. Researchers also looked at changes in liver fat and inflammation us…

This study tested a drug called seladelpar in 96 adults with primary biliary cholangitis (PBC), a rare liver disease. Participants had not responded well or could not tolerate the standard treatment. The goal was to see if seladelpar could lower a key liver enzyme (alkaline phosp…

This completed phase 4 trial tested whether adding SB Flavon (a blend of flavonoids, vitamin C, and L-arginine) to standard Tenofovir therapy can reverse advanced liver scarring (cirrhosis) and prevent liver cancer in 134 people with chronic hepatitis B. The study measured liver …

Liver cirrhosis often causes muscle weakness and frailty, even in stable patients. This study tested whether a personalized diet with extra calories and protein, along with nutrition counseling, could improve muscle strength and quality of life. About 70 adults with stable cirrho…

This study looked at whether giving antibiotics before an endoscopic procedure helps prevent fever and rebleeding in people with cirrhosis who have had variceal bleeding before. 226 patients were randomly assigned to receive the antibiotic ceftriaxone or no antibiotics before the…

This completed phase 2 trial tested a drug called foscenvivint in just 5 people with liver cirrhosis caused by HIV and hepatitis C co-infection who also have hemophilia. The goal was to see if the drug could improve liver function scores over 24 weeks. Because the study is very s…

This study tested a drug called saroglitazar magnesium in 196 adults with primary biliary cholangitis (PBC), a chronic liver disease. Participants either took the drug or a placebo to see if it improved liver function markers. The goal was to lower certain liver enzymes and bilir…

This study compared two antibiotics—ciprofloxacin and ceftriaxone—given intravenously to 310 patients with liver cirrhosis who developed a serious infection called spontaneous bacterial peritonitis. The goal was to see which drug better controlled fever, abdominal pain, and infec…

This study tested whether a combination of two drugs, dasatinib and quercetin, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD) and fibrosis. Thirty adults with biopsy-confirmed liver scarring took either the drug combo or a placebo in cycles ove…

This study tested whether a structured program combining exercise, nutritional advice, and psychological support is safe and doable for frail adults with cirrhosis waiting for a liver transplant. Twenty-five participants were enrolled to see if they could stick with the program a…

This study tested a combination of three drugs (pegylated interferon, ribavirin, and boceprevir) in 58 adults with genotype 1 hepatitis C and cirrhosis who were waiting for a liver transplant. The goal was to see if the treatment could clear the virus before surgery. The study me…

This study tested a drug called BI 770371 in 28 people with compensated cirrhosis caused by MASH, a liver disease linked to metabolism. Participants received either the drug or a placebo as an infusion every 3 weeks for 12 weeks. The main goal was to see how well the drug is tole…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This study tested whether a special blood test (ROTEM) can better guide blood transfusions in people with acute-on-chronic liver failure who are bleeding from enlarged veins. 262 participants were randomly assigned to receive transfusions based on either the new test or standard …

This completed Phase 3 trial tested whether fecal microbiota transplantation (FMT) could help people with liver cirrhosis. Nineteen patients received FMT via colonoscopy. Researchers measured liver stiffness and signs of brain confusion (hepatic encephalopathy) one month later. T…

This early-phase trial tested a lab-made version of human serum albumin (r-HSA) in 36 people with cirrhosis and ascites (fluid buildup in the belly). The goal was to check safety, how the body processes the drug, and whether it might help. Participants received one of three doses…

This study tested a new drug called CNP-104 in 42 adults with primary biliary cholangitis, a rare liver disease, who did not get better with standard treatments. The drug is designed to calm the immune system's attack on the bile ducts. The main goals were to check safety and see…

This study tested whether giving both midodrine (a blood-pressure drug) and albumin (a protein infusion) to children with cirrhosis and fluid buildup (ascites) could prevent serious complications like kidney injury, low sodium, and confusion. Sixty-one children were split into tw…

This study tested whether a lab-made version of a blood protein (recombinant human serum albumin) works as well as the natural version for treating fluid buildup in the belly (ascites) caused by severe liver disease. 390 adults with liver cirrhosis and ascites took part. The goal…

This study tested whether using a computer model to adjust doses of two common drugs (sitagliptin for diabetes and duloxetine for nerve pain) works better in people with liver cirrhosis. 64 patients with cirrhosis, diabetes, and nerve pain were grouped by liver severity and given…

This study tested a smartphone app called ReLiver-N designed to help people with liver cirrhosis take a more active role in their care. The app provides health education, self-management tools, and a system to flag urgent issues. Researchers enrolled 48 patients with mild to mode…

This early-stage study tested a chemotherapy drug called idarubicin mixed with a contrast oil (lipiodol) injected directly into the liver artery for people with liver cancer that cannot be removed by surgery. The 15 participants all had cirrhosis. The goal was to find a safe dose…

This study tested whether a computer program (Simcyp) could predict the right doses of two blood pressure drugs, nebivolol and carvedilol, for people with liver cirrhosis and high blood pressure. Forty patients were randomly assigned to one of the two drugs and monitored for thre…

This early-stage trial tested whether stem cells from donated umbilical cords are safe for people with liver cirrhosis. Twenty adults received an infusion of these cells and were monitored for a year. The main goal was to check for side effects, but researchers also looked for si…

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with cirrhosis, a serious liver condition. 73 adults with cirrhosis took part, receiving either the drug combo, zibotentan alone, or a placebo. The main goal was to check for si…

This study looked at 400 people with liver cirrhosis who had large or complex bile duct stones that couldn't be removed during a first procedure. Doctors placed either one or two plastic stents to help drain the bile and make stones easier to remove later. The goal was to find th…

This completed phase 3 study followed 700 people with liver cirrhosis caused by hepatitis B, C, or fatty liver disease. Researchers took a small amount of bone marrow from each patient, processed it to collect stem cells, and infused those cells back into the patient. The goal wa…

This study looked at whether early liver transplantation can help people with severe alcoholic hepatitis who did not get better with medical treatment. Researchers compared alcohol relapse rates in 284 patients who received early transplants to those transplanted after a 6-month …

This study tested whether giving growth hormone to people with decompensated liver cirrhosis (advanced liver scarring) could improve their health and survival. The trial included 96 adults with this condition. Researchers measured how long patients survived without major complica…

This first-in-human study tested a single dose of PVT201, a nanoparticle-based drug, in 24 people: healthy volunteers and patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC). The main goal was to check safety and how the drug moves through the …

This study tested a monthly injection called AZD2693 in 220 adults with non-alcoholic steatohepatitis (NASH) and liver scarring, who carry a specific genetic risk factor. The goal was to see if the drug could reverse liver inflammation and scarring without making it worse. The tr…

This study tested a new combination of two antiviral pills, bemnifosbuvir and ruzasvir, taken once daily for 8 weeks in 275 adults with chronic hepatitis C. The main goal was to see if the virus was still undetectable 12 weeks after treatment ended. The trial is now complete, and…

This study tested whether giving liver transplant patients a daily high-protein drink for 12 weeks helps them maintain muscle mass. Thirty patients on the transplant list took part. Researchers measured muscle mass with CT scans and tracked how well patients stuck with the drink.…

This study tested a drug called cotadutide in 54 adults with a type of fatty liver disease that includes liver scarring but not cirrhosis. Participants received either the drug or a placebo as a daily injection. The main goal was to check safety and tolerability, with results hel…

This study tested whether nifuroxazide, a drug used for gut infections, can help treat hepatic encephalopathy—a condition where liver disease causes confusion and brain fog. Researchers gave the drug to 80 hospitalized patients with moderate to severe symptoms. The goal was to se…

This study investigates whether non-invasive imaging techniques—ultrasound and MRI—can accurately diagnose non-alcoholic steatohepatitis (NASH) and liver fibrosis in people with fatty liver disease. Currently, a liver biopsy is the gold standard, but it is invasive and carries ri…

This study tests a new ultrasound-based device called the Liver Incytes System to see if it can measure liver stiffness and fat as accurately as MRI and FibroScan. The device uses sound waves to create images of the liver, similar to a traditional ultrasound. Researchers are enro…

This study compares different ways to take a liver biopsy in adults with chronic liver disease, cirrhosis, or who have had a liver transplant. The goal is to see which method—traditional percutaneous (through the belly) or endoscopic ultrasound-guided (through the stomach)—provid…

This study tests whether the inferior vena cava (the body's main vein) can serve as a reliable reference point for measuring blood pressure in the liver during an endoscopic ultrasound. Normally, doctors use a hepatic vein for this, but in people with advanced liver scarring, tho…

This study is testing whether a special drink (EVOC probe) can help detect liver cirrhosis by measuring chemicals in a person's breath. Researchers will compare breath samples from 240 people with and without cirrhosis to build a risk model. The goal is to develop a simple, non-i…

This study explores whether a simple breath test can detect early liver fibrosis in people with non-alcoholic steatohepatitis (NASH). Participants fast overnight, then drink a mixture of food-grade flavor compounds and provide breath samples over 90 minutes. The way the body proc…

This study is testing whether a new type of MRI (4D flow MRI) can detect dangerous veins in the stomach and esophagus of people with cirrhosis, which can cause fatal bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but that is invasive and often unn…

This study tests a computer program called NIMIT-AI that analyzes routine blood test results over multiple doctor visits to detect liver scarring in people with fatty liver disease (MASLD). Unlike the current standard method (FIB-4), which often misses cases and fails with incomp…

This study looked at 639 adults with cirrhosis to see if a blood test called mSEPT9 can detect liver cancer (hepatocellular carcinoma) better than the current standard test (AFP). Participants gave an extra blood sample during routine care, and researchers compared how well each …

This study tested a simple strip test called PeriScreen to quickly diagnose infection in the belly fluid of people with cirrhosis. The goal is to see if the strip can spot infections as accurately as standard lab tests, helping doctors start treatment faster. About 649 adults wit…

This study looked at whether a breath test could help detect liver fibrosis, cirrhosis, or liver cancer. Researchers collected breath samples from 56 patients with known or suspected liver disease and analyzed them for specific chemical markers. The goal was to see if the test co…

This study tested a new, fully automated MRI technique to diagnose liver fibrosis and inflammation without needing a needle biopsy or contrast dye. Researchers scanned 200 adults with chronic liver disease and compared the MRI results to standard biopsy findings. The goal is to p…

This study tested whether a shorter, contrast-enhanced MRI (called AMRI) is better than standard ultrasound for finding liver cancer early in people with cirrhosis. 79 adults with cirrhosis underwent both scans, and researchers compared how accurately each method detected cancer.…

This study looked at whether measuring tiny molecules called microRNAs in the blood can help diagnose liver cancer (hepatocellular carcinoma) in people with hepatitis C. Researchers tested blood samples from 84 participants, including healthy people and those with hepatitis C, wi…

This study compared two methods of taking a liver tissue sample: one using an endoscope with ultrasound (EUS) and the other using a needle through the skin (percutaneous). Researchers wanted to see which method provides better samples for diagnosing liver disease. The trial invol…

This study tested whether a special ultrasound with contrast dye (CEUS) can more accurately identify liver lesions than standard ultrasound or other imaging methods like CT and MRI. Researchers enrolled 878 participants with liver lesions found on standard ultrasound. The goal wa…

This study tested how well a special MRI scan called LiverMultiScan can measure liver fat, iron, and scarring. 61 adults with various liver diseases had up to 6 scans on different machines. The goal was to see if the results are consistent when repeated on the same scanner or on …

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the need for a liver biopsy. Researchers compared FibroScan results with biopsy results in 264 children aged 6 months to 18 years wi…

This study tested whether an artificial intelligence (AI) tool, called ACE 2.0, can detect undiagnosed liver cirrhosis by analyzing a routine electrocardiogram (ECG). Researchers at Mayo Clinic enrolled 279 primary care clinicians and their adult patients. The AI flagged ECGs tha…

This study looked at 100 children with beta-thalassemia major and iron overload to see if simple blood tests (ferritin and hepcidin) can detect liver scarring (fibrosis) as accurately as other non-invasive methods. Researchers measured these blood markers and compared them to ult…

This clinical trial investigates whether two existing medications, allopurinol and atorvastatin, can help prevent serious complications in people with stable liver cirrhosis. The study will compare these drugs against a placebo to see if they reduce the number of acute decompensa…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This completed Phase 3 trial tested whether a combination of lactulose (a medicine) and virtual Tai-Chi (a gentle exercise) could reduce falls and other serious events in 230 people with cirrhosis and portal hypertension. Participants were randomly assigned to different sequences…

This study tested whether the antibiotic rifaximin could prevent a serious brain condition called hepatic encephalopathy in people with cirrhosis who undergo a TIPS procedure. The TIPS procedure helps reduce pressure in the liver but often leads to confusion and other brain issue…

This study looked at whether doxycycline, a common antibiotic, can prevent spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the belly fluid that can be life-threatening. The study included 841 adults with cirrhosis who were at risk f…

This study tested a smartphone app called PatientBuddy designed to help people with cirrhosis and their caregivers manage care at home. The goal was to reduce avoidable hospital readmissions within 30 days after discharge. Researchers enrolled 232 patients and their caregivers to…

This study tests whether a virtual cognitive behavioral therapy program can help people with cirrhosis who also have trouble sleeping. Ten adults with cirrhosis and insomnia will try the program from home. The goal is to see if the program is easy to use and helpful for improving…

This phase 3 trial is testing an experimental drug called linerixibat against a placebo in about 238 adults with primary biliary cholangitis (PBC) who suffer from moderate to severe itching. The goal is to see if linerixibat can reduce itch severity and improve quality of life ov…

This study looked at whether a 16-week brisk walking program, combined with dietary advice, could improve heart rate control and blood vessel health in adults with early-stage cirrhosis (liver scarring). Fifty participants aged 45-75 who were not very active took part. The goal w…

This study tested a home-based physical therapy program called LIFT for people with liver cirrhosis waiting for a transplant. The program included a personalized exercise plan, a smartphone app to track progress, daily text reminders, and regular phone check-ins. The goal was to …

This study tested a 10-week online wellness program for women with primary biliary cholangitis (PBC), a chronic liver disease that causes fatigue, itching, brain fog, and emotional distress. The program included guided breathing, meditation, gentle movement, and optional nutritio…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study looked at whether two drugs, mirabegron and montelukast, are safe and helpful for people with liver cirrhosis who also have overactive bladder and asthma. 78 participants took part over 3 months. Researchers tracked bladder symptoms, breathing issues, and side effects …

This study tested whether a mild electrical stimulation at specific acupoints (TEAS) helps people with cirrhosis tolerate an urgent endoscopy for suspected variceal bleeding. 180 patients were split into three groups: active TEAS, sham TEAS (electrodes but no current), or standar…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The drug works by blocking wakefulness signals in the brain. Researchers measured sleep quality and checked for side effects on the liver. The goal was to see if le…

This study tested two approaches to bring palliative care (comfort-focused care) to people with end-stage liver disease. About 1,500 adults from 19 U.S. centers took part. One group had direct access to a palliative care specialist; the other group saw a liver doctor specially tr…

This early-stage trial tested whether a single dose of hydronidone, an experimental drug for liver fibrosis, changes the heart's electrical activity (QTc interval) in 48 healthy Chinese adults. Participants received one of three doses or a placebo, and researchers measured how th…

This study looks at how the drug hydronidone moves through the body in people with different levels of liver function. Thirty adults with either normal liver function or varying degrees of liver impairment will take a single dose of the drug. The goal is to understand how liver h…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study looks at whether jaundice, a yellowing of the skin and eyes, makes people with cirrhosis more likely to develop infections while in the hospital. Researchers will follow 250 Egyptian patients with cirrhosis to see if those with jaundice get more hospital-acquired infec…

This study looks back at the medical records of 1,000 adults with both chronic hepatitis B and metabolic fatty liver disease. The goal is to understand how these conditions affect kidney function, especially in people on long-term antiviral therapy. Researchers will also examine …

This early study tests whether a single dose of the experimental drug AZD2389 can attach to a protein called FAP in the liver. Twelve adults with advanced liver scarring (fibrosis) will get a PET scan before and after taking the drug to see if it binds to its target. The goal is …

This completed study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 patients about their pain, its location, intensity, and whether it was chronic. The goal was to highlight an often-overlooked issue and encourage better pain care f…

This study investigates how the liver processes nutrients after a meal in healthy individuals and in patients with fatty liver disease or cirrhosis. Researchers will take blood samples and liver biopsies after fasting or eating a standardized meal, and after a glucagon injection.…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study tests whether a special capsule, called SIMBA, can safely collect fluid from the small intestine in people with liver cirrhosis. Participants swallow two capsules, which are later recovered from stool. Researchers will analyze the fluid to compare gut bacteria and meta…

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This study looked at 98 adults with cirrhosis who were hospitalized for sudden worsening of their liver condition. Researchers measured different forms of iron in the blood to see how they relate to short-term death risk. The goal was to better understand iron's role in liver fai…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This completed study looked at over 4.7 million trauma patients in the U.S. to see if those with liver cirrhosis have higher death rates and more infections. Researchers compared patients with and without cirrhosis using hospital records from 2010 to 2018. The goal was to better …

This study looked at health insurance records of over 75,000 people with cirrhosis in France to see if doctors follow guidelines for early liver cancer screening. The goal was to find out how often screening is done correctly and what factors might lead to missed or delayed diagn…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at 480 cirrhosis patients who had variceal bleeding and were getting an endoscopy to prevent future bleeding. Half got antibiotics before the procedure, half did not. The goal was to see if antibiotics reduce infections after the procedure. The study is retrospe…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked at 412 people with cirrhosis who had bleeding from veins in the esophagus or stomach. Half got an endoscopy within 6 hours, the other half between 6 and 24 hours. The goal was to see if faster treatment lowered the chance of rebleeding within 42 days. The result…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked at whether speech features—like how people sound and what they say—can help detect or predict confusion caused by liver disease (hepatic encephalopathy). Researchers recorded speech tasks from 251 participants with cirrhosis and tracked their thinking skills and…

This completed Phase 1 study looked at how the drug seladelpar (Livdelzi) is processed in 24 people with primary biliary cholangitis (PBC) who also have liver impairment. Researchers measured drug levels in the blood and urine to see how the liver condition affects the drug. The …

This study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to see if the program helped patients reach a safe, effecti…

This study tested a wearable sensor called ADAM to measure scratching and sleep patterns in 30 people with primary biliary cholangitis (PBC), a rare liver disease that often causes intense itching and poor sleep. Participants wore the sensor for 7 nights across four 7-day periods…

This study looked at how bacteria from the gut might travel to the liver and make liver disease worse in people with hepatitis C. Thirty adults with stable liver disease took part. Researchers used blood tests, MRI scans, and liver tissue samples to measure bacterial movement and…

This study looked at 211 people with liver cirrhosis to see which screening method works better for detecting liver cancer: an ultrasound every 6 months or an MRI once a year. Participants received both tests, and researchers measured how often each test correctly found cancer. T…

This study looked at how blood clots in people with liver cirrhosis, a condition that can cause bleeding problems. Researchers used a special machine called T-TAS to measure clotting in blood samples from 60 patients. They also tested whether tiny particles that act like platelet…

This study aimed to find new blood markers that can show liver damage in people with anorexia nervosa. Researchers compared blood samples from 19 patients with and without signs of liver injury. The goal is to improve detection and understanding of liver problems in this conditio…

This study looked at 10,000 older adults (age 60+) with fatty liver disease to find out what increases their risk for serious liver problems like scarring, cirrhosis, or liver cancer. Researchers used medical records and yearly check-ups to build a computer model that predicts th…

This study compared two procedures for getting a liver biopsy and measuring liver pressure in people with chronic liver disease or cirrhosis. One method uses a scope through the mouth (endoscopic ultrasound), the other goes through a vein in the neck (transjugular). The goal was …

This study looked at how common liver scarring (fibrosis) is in people with anorexia nervosa. Researchers used a special scan called Fibroscan to measure liver stiffness in 43 patients when they were admitted to the hospital. The goal was to learn more about liver health in this …

This study looked at 82 adults with cirrhosis and portal hypertension (high blood pressure in the liver) to find out how many have minimal hepatic encephalopathy (MHE) — a mild form of brain fog that can affect thinking. Researchers used simple blood tests and thinking exercises …

This study looked at how often acute kidney injury happens in people with liver cirrhosis, and what factors might increase the risk. Researchers at Sohag University Hospital followed 180 adult patients with cirrhosis, excluding those with pre-existing kidney disease or other majo…

This study compared how patients feel about two ways to take a small sample of liver tissue: one using a needle through the skin (percutaneous) and another using a thin tube through the mouth (EUS-guided). 102 adults with chronic liver disease were randomly assigned to one method…

This study looked at 64 adults with liver cirrhosis and a history of variceal bleeding who were scheduled for a TIPS procedure. Researchers measured handgrip strength and then checked how it changed blood pressure in the portal and left gastric veins. The goal was to see if muscl…

This study of 60 people with cirrhosis measured quadriceps (thigh) strength and compared it to standard frailty and malnutrition scores. The goal was to see if a simple leg strength test could replace more complex frailty assessments. No treatment was given; it was purely an obse…

This completed study looked at 3 liver transplant patients to see if muscle loss (sarcopenia) changes how the body responds to the muscle relaxant rocuronium. Researchers measured hand grip strength and used a questionnaire to diagnose sarcopenia before surgery, then tracked how …

This early-phase study looked at how the body breaks down nalbuphine extended-release tablets in people with mild, moderate, or severe liver impairment compared to healthy volunteers. It also explored whether the drug could relieve itching in those with liver problems. The study …

This study aimed to create new mathematical models to better predict which patients with severe liver disease are at highest risk of dying while waiting for a liver transplant. Researchers analyzed data from 501 adults on the French national transplant waiting list. The goal is t…

This study looked at how safe and effective a combination of two drugs (Atezolizumab and Bevacizumab) is for people with liver cancer and cirrhosis, compared to standard pills (tyrosine kinase inhibitors). Researchers followed 38 patients to see how long they lived and how their …

This study tested whether a computer program could help doctors choose the right dose of simvastatin for people with cirrhosis and high blood pressure in the liver. Twenty-two patients received either 5 mg or 15 mg of simvastatin daily for three months. Researchers measured chang…

This completed study examined 292 people with non-alcoholic fatty liver disease (NAFLD) to see if liver scarring is linked to heart disease risk. Researchers used non-invasive tests like the coronary calcium score and liver elastography. The goal was to better understand how to s…

This study tested a new scoring system called the Intensive Care Cirrhosis Outcome (ICCO) score to see how well it predicts survival in cirrhosis patients admitted to the ICU. Researchers calculated the score for 150 adult patients using routine lab tests and tracked their outcom…

This study followed 711 adults with primary biliary cholangitis (PBC) for 5 years to see how the disease is managed in everyday medical practice. Researchers collected data on treatments, lab results, and side effects, and also stored blood samples for future genetic research. Th…

This completed study looked at 574 hospitalized adults with end-stage liver disease to see if alcoholic patients had the same chance of getting on the national liver transplant waiting list as non-alcoholic patients. The goal was to find out if non-medical reasons limit access fo…

This study looked at whether measuring liver pressure during an endoscopy is more accurate when patients lie on their left side versus flat on their back. Researchers tested 30 hospitalized patients with liver cirrhosis. The goal was to see if the two positions give consistent re…

This study tested a telemedicine platform called myLIVERcoach in 50 adults with liver cirrhosis. Participants used the app alongside standard care to answer questionnaires and track symptoms, aiming to catch complications early. The goal was to see if patients, caregivers, and do…

This completed study examined how to best manage early-stage upper gastrointestinal cancer in patients who also have liver cirrhosis and enlarged veins in the esophagus (varices). Researchers compared outcomes of a keyhole-like endoscopic surgery (ESD) between 206 patients with a…

This study looked at over 5,000 adults in Zambia to find out how many have hepatitis B and how many need treatment. Researchers tested people in their homes and then did more tests on those who tested positive. The goal was to gather information, not to test a new treatment or cu…

This study looked at how the body processes four common drugs (rosuvastatin, digoxin, metformin, and furosemide) in healthy people and those with liver cirrhosis. Researchers measured drug levels in the blood to see if liver disease changes how these medicines are handled. The go…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This study looked at 82 adults getting a liver transplant to see if using a special blood test called ROTEM helps doctors manage bleeding better than standard tests. The goal was to see if ROTEM could reduce the amount of blood products given during surgery. Researchers tracked c…

This study looked at whether a heart ultrasound (echocardiography) can help doctors better manage liver cirrhosis patients who also develop sudden kidney injury. Researchers examined 28 patients to see how their heart function related to their kidney problem. The goal was to impr…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This completed study looked at the genetic makeup of liver cancer in 808 patients to better understand the disease. Researchers analyzed tumor samples from people treated with surgery, ablation, or transplant, as well as those with advanced cancer. The goal was to identify key ge…

This completed study from University Hospital Freiburg looked back at 490 patients with liver cirrhosis and signs of chronic kidney disease who were treated for hepatorenal syndrome. Researchers compared how well patients with and without pre-existing kidney disease responded to …

This study looked at how the drug zibotentan is absorbed and cleared by the body in 30 healthy adults, including both non-Asian and Japanese participants. It was a phase 1 trial, meaning it was an early step to gather safety and drug-level information. The study did not aim to tr…

This study compared four non-invasive methods—FibroTest, Fibroscan, ShearWave Elastography, and Magnetic Resonance Elastography—to measure liver fibrosis in 56 children with cystic fibrosis aged 6-18. The goal was to see which test best detects early liver damage, helping doctors…

This study tested whether people with cirrhosis learn more from watching a video or reading text about their condition. 218 adults with cirrhosis took a quiz before and after receiving either a video or written educational material. The goal was to see which method improved knowl…

This study looked at whether a blood test called cystatin C is more accurate than the standard creatinine test for measuring kidney function in people with severe liver disease. Researchers compared these lab tests to a precise radioactive tracer method in 213 adults being evalua…

This study looked at 100 adults hospitalized with liver cirrhosis to see how many survived within 90 days and what factors increased their risk of death. Researchers collected basic health information and followed patients for three months. The goal was to better understand which…

This study looks at the genetic makeup of 1,500 people with Primary Biliary Cirrhosis (PBC), a rare liver disease, along with their close relatives. By comparing genes, researchers hope to find inherited factors that make someone more likely to develop PBC. The goal is to better …

This study looked at how the drug AZD2389 behaves in people with liver impairment compared to healthy volunteers. 35 adults took a single dose, and researchers measured drug levels in the blood to check safety and processing. The goal is to understand if liver problems change how…

This study looked at how well people with liver cirrhosis can find and understand health information online. 86 patients filled out two questionnaires about their digital skills and ability to read health charts. The goal was to learn about their digital health literacy, not to t…

This study tested whether a health app (Patient Buddy and EncephalApp) plus scheduled follow-up calls and visits could reduce avoidable hospital readmissions within 30 days in 232 cirrhosis patients. Patients and their caregivers were trained on the app and received daily contact…

This completed study looked at how people with and without liver cirrhosis process five common medicines: caffeine, warfarin, omeprazole, metoprolol, and midazolam. Only 4 participants took part, including healthy volunteers and those with mild or moderate cirrhosis. Researchers …

This study compared different methods to estimate how much fluid is needed in patients with liver cirrhosis or acute-on-chronic liver failure who also have sepsis and low blood pressure. Researchers enrolled 350 adults and looked at whether using ultrasound-guided fluid assessmen…