New pill combo aims to cure hepatitis c in just 8 weeks
NCT ID NCT05904470
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new combination of two antiviral pills, bemnifosbuvir and ruzasvir, taken once daily for 8 weeks in 275 adults with chronic hepatitis C. The main goal was to see if the virus was still undetectable 12 weeks after treatment ended. The trial is now complete, and results will show how safe and effective this short treatment course is.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bemnifosbuvir and ruzasvir (oral antiviral drugs)
What this could lead to
If successful, this could provide a new, shorter treatment option for chronic hepatitis C, potentially curing the infection in most patients.
What could go wrong
This is a Phase 2 trial, so results are preliminary. The combination may not work for all hepatitis C genotypes or in patients with cirrhosis, and side effects are still being evaluated.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Atea Study Site
San Antonio, Texas, 78215, United States
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Atea Study Site
Manaus, Amazonas, 69040-000, Brazil
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Atea Study Site
Salvador, Estado de Bahia, 41920-900, Brazil
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Atea Study Site
Brasília, Federal District, 70200-730, Brazil
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Atea Study Site
Rio de Janeiro, Rio Do Janeiro, 04037-030, Brazil
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Atea Study Site
Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
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Atea Study Site
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Atea Study Site
Porto Velho, Rondônia, 78918-791, Brazil
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Atea Study Site
Boa Vista, Roraima, 69304-015, Brazil
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Atea Study Site
Botucatu, São Paulo, 18618-970, Brazil
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Atea Study Site
Ijuí, São Paulo, 98700-000, Brazil
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Atea Study Site
São José do Rio Preto, São Paulo, 15090-000, Brazil
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Atea Study Site
São Paulo, São Paulo, 04119-001, Brazil
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Atea Study Site
São Paulo, São Paulo, 05403-000, Brazil
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Atea Study Site
Sorocaba, São Paulo, 18052-210, Brazil
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Atea Study Site
Vancouver, British Columbia, V6Z 2C7, Canada
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Atea Study Site
Toronto, Ontario, M5G 2C4, Canada
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Atea Study Site
Rajkot, Gujarat, 360005, India
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Atea Study Site
Surat, Gujarat, 395002, India
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Atea Study Site
Belagavi, Karnataka, 590010, India
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Atea Study Site
Nagpur, Maharashtra, 440010, India
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Atea Study Site
Kolkata, West Bengal, 700020, India
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Atea Study Site
Quatre Bornes, 72218, Mauritius
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Atea Study Site
Chisinau, 2025, Moldova
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Atea Study Site
Karachi, 74800, Pakistan
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Atea Study Site
Karachi, 75600, Pakistan
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Atea Study Site
Baguio City, 35100, Philippines
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Atea Study Site
Iloilo City, 5000, Philippines
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Atea Study Site
Mabalacat, 2023, Philippines
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Atea Study Site
Bucharest, BUC, 022328, Romania
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Atea Study Site
Bucharest, BUC, 30303, Romania
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Atea Study Site
Constanța, CON, 900709, Romania
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Atea Study Site
Craiova, DOL, 200073, Romania
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Atea Study Site
Bucharest, 21105, Romania
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Atea Study Site
Bloemfontein, Free State, 9301, South Africa
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Atea Study Site
Johannesburg, Gauteng, 2193, South Africa
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Atea Study Site
Randburg, Gauteng, 2087, South Africa
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Atea Study Site
Somerset West, Western Cap, 7130, South Africa
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Atea Study Site
Seoul, Gyeonggi-do, 120-752, South Korea
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Atea Study Site
Yangsan, Gyeongsangnam, 626-770, South Korea
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Atea Study Site
Busan, 47392, South Korea
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Atea Study Site
Busan, 49241, South Korea
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Atea Study Site
Seoul, 5505, South Korea
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Atea Study Site
Seoul, 6351, South Korea
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Atea Study Site
Adana, 1130, Turkey (Türkiye)
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Atea Study Site
Ankara, 6100, Turkey (Türkiye)
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Atea Study Site
Ankara, 6230, Turkey (Türkiye)
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Atea Study Site
Ankara, 6800, Turkey (Türkiye)
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Atea Study Site
Denizli, 20070, Turkey (Türkiye)
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Atea Study Site
Izmir, 35100, Turkey (Türkiye)
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Atea Study Site
Kayseri, 38010, Turkey (Türkiye)