New infusion drug targets MASH cirrhosis in small safety trial

NCT ID NCT06675929

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called BI 770371 in 28 people with compensated cirrhosis caused by MASH, a liver disease linked to metabolism. Participants received either the drug or a placebo as an infusion every 3 weeks for 12 weeks. The main goal was to see how well the drug is tolerated and to check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BI 770371 (given as an infusion into a vein)
What this could lead to: If it works, this could point toward a treatment to slow or manage liver damage in people with MASH-related cirrhosis.
What could go wrong: This is a small, early-phase trial focused on safety, not effectiveness. The drug may not improve liver health or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COMPENSATED LIVER CIRRHOSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cirrhosis of liver metabolic dysfunction-associated steatohepatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPENSATED LIVER CIRRHOSIS METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH)

Contacts and locations

Locations

American Research Corporation at the Texas Liver Institute

San Antonio, Texas, 78215, United States
Blessed Health Care

Miami, Florida, 33174-3245, United States
Catalina Research Institute, LLC-Montclair-49051

Montclair, California, 91763, United States
Evolution Clinical Trials

Miami, Florida, 33122, United States
Houston Research Institute

Houston, Texas, 77079, United States
Inland Empire Clinical Trials, LLC

Rialto, California, 92377, United States
Knowledge Research Center

Orange, California, 92868, United States
Peak Gastroenterology Associates-Colorado Springs-67762

Colorado Springs, Colorado, 80907, United States
Pinnacle Clinical Research, LLC

San Antonio, Texas, 78229, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
Southern California Research Center

Coronado, California, 92118, United States
The Institute for Liver Health II dba Arizona Clinical Trials

Chandler, Arizona, 85225, United States
The Liver Institute at Methodist Dallas

Dallas, Texas, 75203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.