Could a simple breath test spot liver cirrhosis early?

NCT ID NCT07035158

Completed Diagnosis Sponsor: Owlstone Ltd Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study is testing whether a special drink (EVOC probe) can help detect liver cirrhosis by measuring chemicals in a person's breath. Researchers will compare breath samples from 240 people with and without cirrhosis to build a risk model. The goal is to develop a simple, non-invasive test that could be used in doctor's offices to screen for cirrhosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Libra Oral Solution (EVOC Probe)
What this could lead to: If successful, this could lead to a simple, non-invasive breath test to screen for liver cirrhosis in primary care, reducing the need for more invasive procedures.
What could go wrong: This is an early-stage case-control study (240 participants) to develop a risk model, not a validation trial. The test may not perform well in broader populations or different settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS, LIVER

Contacts and locations

Locations

Arizona Liver Health

Chandler, Arizona, 85224, United States
Hospital Padre Hurtrado

Santiago, Chile
Norfolk and Norwich Hospital

Norwich, NR4 7UQ, United Kingdom
Peterborough City Hospital

Peterborough, PE3 9GZ, United Kingdom

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