Skeletal system disorder

Researchers test a one-time gene therapy infusion in children and adults with Sanfilippo syndrome (MPS IIIB), a rare inherited disease that damages the brain and body. The therapy delivers a working copy of the NAGLU gene to help the body make an enzyme that is missing or faulty.…

This study tests whether bone marrow from deceased donors can be used to treat people with blood cancers like leukemia and lymphoma. Participants receive a transplant of cryopreserved marrow from a deceased donor or standard cells from a living donor. The goal is to see if the de…

This trial is testing whether a new conditioning regimen, called VABu, can improve outcomes for adults with acute myeloid leukemia (AML) who are in first remission but are too frail for standard transplant prep. The regimen combines venetoclax, azacitidine (or decitabine), and bu…

This trial tests a combination of two drugs, azacitidine and venetoclax, as the first treatment for young, fit adults (ages 18-50) with newly diagnosed acute myeloid leukemia (AML). The goal is to see how many patients achieve complete remission after one or two cycles of this th…

This trial is testing whether adding venetoclax to standard intensive chemotherapy plus midostaurin can improve outcomes for adults with a type of acute myeloid leukemia that has a FLT3 mutation. The study enrolls people aged 18 to 70 with newly diagnosed disease who are healthy …

Researchers are testing a three-drug regimen called VAM for older or unfit adults with newly diagnosed acute myeloid leukemia (AML). The regimen combines liposomal mitoxantrone, azacitidine, and venetoclax. The trial aims to find the safest and most tolerable dose of liposomal mi…

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This study compares two FDA-approved drugs, momelotinib and ruxolitinib, in people with myelofibrosis who also have low blood cell counts. The main goal is to see which drug does a better job at shrinking the spleen and reducing the need for blood transfusions. About 268 particip…

When children lose bone to injury, infection, or surgery, doctors can rebuild the limb in different ways. This French study compares two established techniques: the induced membrane method and the vascularized fibula flap, which moves a piece of the calf bone with its blood suppl…

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

Researchers compare two ways to treat deep defects in the gums of people with advanced periodontitis. One approach cleans the pockets with minimally invasive non-surgical therapy, while the other uses a single flap surgical procedure. The trial measures gum attachment gain and us…

This study tests a digital health program designed to support people with psoriatic arthritis in managing their condition. Participants use a mobile app for symptom tracking and lifestyle tips, plus tools for sleep, stress, and physical activity, along with a smartwatch. The goal…

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of …

This phase 3 trial compares adding doxorubicin and ifosfamide (AIM chemotherapy) before standard treatment with pembrolizumab, radiation therapy, and surgery versus standard treatment alone in patients with high-risk soft-tissue sarcomas that can be removed by surgery. Participan…

This trial tests whether screening older adults for sarcopenia (loss of muscle strength and mass) before hip replacement surgery, followed by a structured exercise program after surgery, can improve recovery. Participants aged 65 and older with advanced hip osteoarthritis will be…

This trial tests whether adding an experimental drug called DT-7012 to standard chemotherapy (doxorubicin) helps people with advanced soft tissue sarcoma, specifically two subtypes: undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. Participants receive either…

This trial tests an experimental drug called PF-08154225 in people with autoimmune diseases like lupus, rheumatoid arthritis, myositis, or scleroderma. The drug aims to calm the immune system, which mistakenly attacks healthy cells in these conditions. Participants receive the dr…

This phase 2 trial tests a three-part treatment for people with high-risk undifferentiated pleomorphic sarcoma (UPS), a rare cancer of soft tissue. Participants receive focused radiation (SBRT), the immunotherapy drug toripalimab, and a lower dose of the chemotherapy drug liposom…

This Phase 2 trial tests a combination of two drugs—blinatumomab (given as a shot under the skin) and olverembatinib (a pill)—in 60 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see if this combo can control the disease safely. Pa…

This pilot study tests whether a home-based device that stimulates the vagus nerve through the ear can reduce pain and inflammation in veterans with knee osteoarthritis. Researchers will compare two different daily doses of this nerve stimulation against a standard steroid inject…

Researchers are testing whether a toothpaste containing isopropyl methyl phenol reduces plaque buildup and gum bleeding better than a regular fluoride toothpaste. The 12-week study enrolls 120 Chinese adults with plaque-induced gingivitis. Dentists measure gum bleeding at weeks 2…

This trial tests whether adding nicorandil, a drug that widens blood vessels, to standard rheumatoid arthritis (RA) treatment can reduce the buildup of plaque in arteries. People with RA have a higher risk of atherosclerosis, which can lead to heart attacks and strokes. Researche…

This phase II trial tests an investigational drug called TST002 in postmenopausal women aged 45 to 80 who have osteoporosis or low bone mass. The study compares three different doses of TST002 against a placebo and an existing osteoporosis drug, denosumab. The main goal is to see…

This early-phase trial is testing an experimental therapy called GT737 for adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatment. GT737 uses specially engineered immune cells (iNKT cells) that are made in large batches and can be given…

This study tests whether adding the experimental drug IPN60340 to standard medicines (azacitidine and venetoclax) helps more people with newly diagnosed acute myeloid leukemia (AML) achieve complete remission. About 450 adults who cannot have intensive chemotherapy will take part…

This trial tests whether adding laser therapy to standard gum surgery improves treatment of advanced periodontitis. Adults with stage I to III periodontitis who still have deep pockets after initial non-surgical care will receive open flap debridement, a procedure that lifts the …

Researchers are testing whether a 2% melatonin gel placed directly into gum pockets can improve outcomes when added to standard non-surgical periodontal therapy. The trial enrolls 23 systemically healthy adults with Stage II Grade B periodontitis. Each participant receives standa…

Researchers are testing whether adding hydroxychloroquine to oral decitabine and venetoclax helps adults with acute myeloid leukemia (AML) that has relapsed or stopped responding to similar treatment. The study enrolls about 18 people with relapsed or refractory AML, or newly dia…

This study tests a new combination of three drugs—revumenib, azacitidine, and venetoclax—in people newly diagnosed with a specific, hard-to-treat leukemia called KMT2A-rearranged AML. The goal is to see if this cocktail can help more patients achieve remission with fewer side eff…

Researchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…

Dentists often replace a failed filling in a baby tooth by drilling it out and starting over. This trial tests a gentler option: repairing just the broken part and leaving the healthy filling in place. Researchers will assign 824 baby molars from children aged 4 to 8 to either re…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This phase II trial tests whether adding venetoclax to standard chemotherapy and stem cell transplant, followed by venetoclax maintenance, helps adults with acute myeloid leukemia (AML) stay in remission longer. About 244 participants will receive either venetoclax or a placebo a…

This trial tests two different types of drugs—an IL-17 inhibitor (secukinumab) and a JAK inhibitor (upadacitinib)—in people with axial spondyloarthritis who have not improved with a TNF inhibitor. The goal is to see which approach is more effective at reducing disease activity ov…

This phase 2 trial tests whether adding olutasidenib to standard treatments helps people with IDH1-mutated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). For AML, the standard is a chemotherapy pill plus venetoclax; for higher-risk MDS, it's the chemotherapy pill…

Researchers are testing an experimental drug called ORM-1153 in adults whose acute myeloid leukemia (AML) or other blood cancer has returned or stopped responding to treatment. The drug targets CD123, a protein found on the surface of these cancer cells. Participants receive ORM-…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This trial tests whether postural correction exercises can improve pelvic floor muscle function in postmenopausal women aged 55 to 65 who have osteoporosis and mild to moderate pelvic floor dysfunction. Participants receive estrogen replacement therapy and general posture advice,…

This early-stage trial tests a new drug called JR-446 in 12 children under 6 with MPS IIIB, a rare genetic disorder that damages the brain and body. The main goal is to see if the drug is safe and tolerable. Researchers will also measure changes in certain substances in the body …

This trial tests whether a one-bottle or a two-bottle HEMA-free dental adhesive works better for filling cavities on the front surfaces of teeth. About 50 adults with early to moderate cavities will receive a filling using one of the two adhesives. Researchers will check how well…

This study compares two treatment combinations for adults with psoriatic arthritis who did not get enough relief from methotrexate alone. One group will receive apremilast plus methotrexate, the other adalimumab plus methotrexate. Researchers will measure joint and skin disease a…

This trial tests whether adding injectable platelet-rich fibrin (i-PRF) or hyaluronic acid gel to standard free gingival graft surgery improves healing and reduces graft shrinkage. Adults with gum recession and insufficient keratinized tissue will be randomly assigned to one of t…

This study tests whether using an electric flosser along with a manual toothbrush and fluoride toothpaste reduces plaque and gum inflammation more than brushing alone. About 80 adults with mild gum disease will follow one of two routines for 30 days. Researchers will measure chan…

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin, improves the results of regenerative surgery for severe gum disease. Adults with stage III periodontitis and deep bone defects will receive standard surgery with a bone gra…

This trial compares two ways to treat tooth decay at the gum line in elderly cancer patients. One method uses a silver solution to stop decay without drilling, then places a filling. The other uses the traditional approach of drilling out the decay before filling. The study will …

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This phase II trial tests asciminib as the first treatment for adults newly diagnosed with chronic myeloid leukemia in chronic phase. Patients with unfavorable risk factors also receive dasatinib starting four weeks later. The study measures how many patients achieve a major mole…

This trial gives deucravacitinib, an oral drug that calms the immune system, to adults with lupus or Sjögren's disease and to children with psoriasis or psoriatic arthritis. Participants join after finishing an earlier study of the same drug, and the goal is to see how safe and t…

This Phase 3 trial tests whether a multi-component oral hygiene regimen, including specific mouthwashes and toothpaste, improves outcomes in adults with stage II periodontitis undergoing non-surgical periodontal treatment. Participants will use either an active regimen or a place…

This trial tests whether adding a procedure called expansile duraplasty — opening and expanding the tough membrane around the spinal cord — to standard spinal surgery can improve neurological recovery in adults with acute severe spinal cord injury. Participants are randomly assig…

This trial is testing an experimental drug called S243249, which blocks a protein called menin, in people whose acute leukemia has come back or not responded to standard treatment. The study focuses on patients with specific genetic changes (KMT2A or NUP98 translocations, or NPM1…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This trial tests whether a modified gum graft technique, called a vertically coronally advanced flap, covers exposed tooth roots better than the standard coronally advanced flap. Both methods use a connective tissue graft to thicken the gum. Researchers will measure how much the …

This trial tests whether an 8-week upper-limb resistance training program can improve cardiovascular autonomic function in adults with chronic spinal cord injury. Participants are randomly assigned to either supervised arm exercises three times per week or a control group. Resear…

This trial tests two resin infiltration systems, ICON and I-Mate, to see which better masks white spot lesions on front teeth and matches the natural tooth color. Researchers will enroll 50 people aged 16 to 35 who have non-cavitated white spots, often from previous braces. Parti…

This trial tests whether adding a nasal spray made from pistacia lentiscus oil can help people with chronic rhinosinusitis control their symptoms while using a lower dose of a standard corticosteroid spray. Adults with the condition will be randomly assigned to either the oil spr…

This trial tests whether NVG-291, an investigational peptide, can improve hand function and daily activities in adults with chronic cervical spinal cord injury. Participants receive either NVG-291 or a placebo by daily injection under the skin for 12 weeks. Researchers measure ch…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This trial tests whether daily seated cycling, started within two days of spinal surgery, can improve recovery in people with a mild spinal cord injury. Researchers will compare 107 participants who cycle for 30 minutes each day during their hospital stay with a similar group who…

This study investigates whether a patient's own platelet concentrate, called A-PRF, can improve early wound healing after tooth extraction in people at high risk for medication-related osteonecrosis of the jaw (MRONJ). Participants are adults who have taken or are taking bone-str…

This trial looks at people who have both periodontitis (gum disease around natural teeth) and peri-implantitis (inflammation around dental implants). Researchers will measure three proteins in the fluid around teeth and implants before and after routine non-surgical therapy, whic…

This early-stage trial tests giving a gene therapy to unborn babies diagnosed with GM1 gangliosidosis, a severe genetic disorder that damages the brain and body. The therapy uses a harmless virus to deliver a working copy of the missing enzyme gene. The main goal is to see if the…

This study tests whether one or two applications of 38% silver fluoride can stop cavities in the baby teeth of children aged 4 to 6 years. Researchers compare a single treatment against two treatments given three months apart, and also measure how the children's oral health affec…

This trial tests whether a single oral dose of ondansetron, a drug that curbs vomiting, can help children with cholera keep down oral rehydration solution (ORS). About 120 children aged 6 months to 17 years with suspected or confirmed cholera and active vomiting will receive eith…

This trial tests whether adding a gel made from a patient's own blood, called albumin platelet-rich fibrin (Alb-PRF), to standard nonsurgical gum treatment improves healing of deep gum pockets in adults with periodontitis. Each participant has matched gum sites randomly assigned …

This study looks at how well children regain their chewing strength after getting a crown on a decayed baby molar. It compares two types of crowns: a newer BioFlx crown and the standard stainless-steel crown. Thirty children aged 5 to 8 with tooth decay will receive one of these …

This trial compares two minimally invasive ways to treat cavities in children's back baby teeth. The standard Hall Technique seals the cavity with a stainless steel crown, without drilling or numbing. The SMART Hall technique adds a silver diamine fluoride (SDF) coating before se…

This trial tests whether adding inspiratory muscle training (IMT) — breathing exercises using a resistance device — to usual care can improve cardiopulmonary endurance and functional mobility in people with knee osteoarthritis. Adults aged 40-65 with bilateral knee osteoarthritis…

This trial tests whether combining traditional Ayurvedic treatments with standard medical care can better ease knee osteoarthritis symptoms than either approach alone. It enrolls 300 adults aged 30-65 with mild to moderate knee osteoarthritis, randomly assigning them to receive s…

This trial tests whether a gel made from a patient's own blood, called injectable platelet-rich fibrin (I-PRF), can improve the results of a minimally invasive non-surgical treatment for advanced gum disease. Researchers will compare three approaches: the standard deep-cleaning p…

This trial compares two surgical techniques used when a dental implant is placed immediately after removing a tooth in the upper front of the mouth. The goal is to see which technique better preserves the thin bone in front of the socket and the gum around the implant, which ofte…

This study tests whether a special collagen matrix can replace tissue taken from the roof of the mouth to fix receding gums. Forty adults with at least two areas of gum recession will receive either the collagen matrix or a standard palate graft. The main goal is to see how much …

This pilot trial is testing a digital health program called CHALAANE, which means 'walk' in Hindi and Urdu, for South Asian adults with knee osteoarthritis and obesity. The program combines a smartband, an AI-powered mobile app for tracking diet and activity, and a 12-week superv…

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This phase 3 trial tests whether the experimental drug felcorekibart, added to standard care, can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a…

This phase 3 trial tests whether an experimental drug called felcorekibart can reduce nasal polyps and improve symptoms like nasal blockage and loss of smell in adults with chronic rhinosinusitis with nasal polyps. Participants receive either felcorekibart or a placebo on top of …

This early-stage trial tests an investigational drug called CBX-663 in adults with certain advanced cancers that have not responded to standard treatment or have returned. The study includes people with blood cancers (like AML, MDS, or CMML), advanced solid tumors, or a type of b…

This trial tests whether two oral antibiotic combinations—doxycycline with levofloxacin or moxifloxacin—can treat brucellosis as effectively as the standard doxycycline-rifampicin regimen. Brucellosis is a bacterial infection from animals that can cause fever and joint pain, and …

This study is following people who receive a Tornier Perform™ Reversed MonoPost shoulder replacement to see how well it works and how safe it is. The implant is designed for patients with severe shoulder damage, such as from arthritis, fractures, or failed previous surgeries. Res…

This trial asks whether GLP-1 receptor agonists, a class of drugs used for weight management, can improve gum health and boost the response to standard deep-cleaning treatment in people with obesity and periodontitis. Adults with both conditions will be split into two groups: tho…

This trial tests whether a short course of romosozumab followed by denosumab can increase bone density more than the standard treatment zoledronic acid in postmenopausal women with osteoporosis and high fracture risk. Participants receive either the romosozumab-denosumab sequence…

This trial is testing whether adding hydroxyurea to a standard chemotherapy combination can improve outcomes for adults with acute myeloid leukemia (AML) that has returned or not responded to treatment. The study is conducted in two parts: first to find the safest dose of hydroxy…

This trial is testing whether a minimally invasive technique for robotic knee replacement, which uses a smaller incision and less tissue disruption, can improve scar appearance and recovery compared to the standard approach. The study will involve 100 adults with knee osteoarthri…

This phase 2 trial is testing whether combining two immunotherapy drugs—vilastobart and retifanlimab—can shrink tumors in people with metastatic pancreatic cancer that has a BRCA1, BRCA2, or PALB2 gene mutation. Participants receive both drugs by IV infusion over several months. …

This study follows about 1,020 people who receive the oneKNEE total knee prosthesis during knee replacement surgery. Researchers track safety and how well the implant works by measuring changes in knee pain and function using the Oxford Knee Score two years after surgery. The goa…

This study looks at how well the drug asciminib works and how safe it is for young adults with chronic myeloid leukemia (CML) in the Gulf region. Researchers will collect information from medical records of about 80 people aged 18 and older who have taken asciminib. The main goal…

This trial tests whether adding gilteritinib to the standard drugs azacitidine and venetoclax can help adults with a type of acute myeloid leukemia (AML) that has returned or stopped responding to prior treatment. Participants receive the three-drug combination in repeated 28-day…

This phase 2 trial is testing whether an oral drug called flonoltinib maleate can help adults with myelofibrosis, a rare bone marrow disorder that often causes an enlarged spleen and severe symptoms. The study compares three different daily doses (50 mg, 75 mg, and 100 mg) to see…

This trial tests whether extra follow-up—via phone calls, digital messages, or both—helps people recover better after a tooth extraction. Adults having a tooth pulled will get standard instructions, and some will also receive structured phone or digital check-ins during the first…

This trial tests two methods for sealing the socket left after a tooth is removed, with the goal of preserving the gum and bone for a future replacement. One method uses a fixed, 3D-printed temporary tooth that supports the gum tissue, while the other uses a removable plastic gua…

This trial tests whether a one-time injection of a person's own concentrated fat can reduce pain and improve function in adults with chronic tendinopathy—tendon pain lasting more than three months that hasn't improved with usual treatments. Participants undergo a same-day procedu…

This trial tests whether cold atmospheric plasma can match standard sodium hypochlorite irrigation for disinfecting root canals in teeth with dead nerves. Sixty adults with a single necrotic tooth will receive one of the two treatments. Researchers will compare post-treatment pai…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This trial tests a new surgical technique that avoids cutting the gum tissue between teeth to repair deep bone defects caused by gum disease. The procedure uses a synthetic bone graft and a special gel to help the bone regenerate. The study includes 60 adults aged 35 to 65 with a…

This early-stage trial is testing whether combining a robotic exoskeleton with spinal cord stimulation can help people with chronic spinal cord injury walk more easily. The study will include a small group of adults who already have a spinal stimulator implanted and have complete…

This phase 2 trial is testing whether lifileucel, a therapy made from a patient's own tumor-infiltrating lymphocytes (immune cells), can shrink tumors in adults with advanced soft tissue sarcoma. Participants will have their tumor removed to create the personalized therapy, then …

This trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…

This phase 3 trial tests a drug called tralesinidase alfa in 14 children aged 1-5 with Sanfilippo syndrome type B, a rare genetic disease that causes severe brain damage. The drug is given directly into the brain fluid to replace a missing enzyme. The goal is to see if it can slo…

This phase 2 trial tests whether using a comprehensive geriatric assessment to guide treatment selection can reduce side effects and improve outcomes in adults aged 60 and older with newly diagnosed acute myeloid leukemia. Participants are classified as fit, vulnerable, or frail,…

This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The …

This phase 3 trial tests whether giving radiation therapy early — before symptoms appear — can reduce the risk of bone complications (like fractures or spinal cord pressure) in people with solid tumors that have spread to the bone. Participants have bone lesions that are consider…

This trial investigates whether revumenib, a menin inhibitor, can safely and effectively treat myelofibrosis, a type of bone marrow cancer. The study first tests revumenib alone in patients who have already tried a JAK inhibitor, then tests it in combination with a JAK inhibitor.…

This study tests an experimental drug called dibotatug (DR-01) in adults with bone marrow failure syndromes, including severe aplastic anemia. The goal is to see if the drug is safe and can improve blood cell counts. Participants receive dibotatug by IV infusion, and researchers …

This trial tests whether adding a posterior cervical fusion (using the CORUS PCSS 3D device) to the standard anterior cervical discectomy and fusion (ACDF) improves bone fusion success for people with two-level degenerative disc disease in the neck. About 225 adults with neck or …

This trial compares two types of platelet-rich plasma (PRP) injections for people with tennis elbow that hasn't improved with standard treatments. One injection uses PRP made from the patient's own bone marrow, while the other uses PRP from their blood. The study aims to see if t…

This study investigates whether a daily probiotic lozenge containing Limosilactobacillus reuteri can reduce inflammation and improve gum health in adults with severe periodontal disease. Researchers will also analyze participants' oral and gut bacteria to identify who is most lik…

This trial compares robotic-assisted total knee replacement to the conventional manual approach in adults with knee osteoarthritis. All participants follow the same structured home-based rehabilitation program before and after surgery. The study measures knee pain, function, and …

This clinical trial tests whether injecting a person's own purified blood cells into the knee can reduce pain and improve movement in people with knee osteoarthritis. The study compares two doses of these cells against a standard steroid injection. Participants are adults aged 40…

This trial investigates whether taking pimicotinib—a drug that blocks a protein driving tumor growth—for 12 weeks before surgery can improve outcomes for people with diffuse tenosynovial giant cell tumor (D-TGCT), a rare but aggressive joint tumor with a high recurrence rate. Par…

This trial compares a standardized siwak (chewing stick) oral hygiene program to conventional toothbrushing for improving gum health in young adults with gingivitis. Participants are dental students aged 18–24 who will follow either the siwak module or toothbrushing for 21 days. …

This trial tests whether a device that uses alternating magnetic fields to heat metal knee implants can help treat infections without removing the implant. Adults with a knee implant infection receive surgery, antibiotics, and either active or sham magnetic treatment. The study m…

This trial investigates whether adding bacteriophages—viruses that specifically target and kill bacteria—to standard surgery and antibiotics can improve outcomes for people with infected hip or knee replacements. The study enrolls adults with an infection caused by Staphylococcus…

This study looks at how well the chemotherapy drug temozolomide works for people with aggressive pituitary tumors or pituitary cancer that hasn't responded to standard treatments like surgery or radiation. Researchers are collecting data from medical records across multiple hospi…

This early-phase trial tests a single injection of PID23, a gene therapy that instructs a patient's own immune cells to attack leukemia cells. It targets three markers (CD19, BCMA, and CD70) on cancer cells. The study enrolls up to 18 people aged 3 to 75 with relapsed or refracto…

This trial tests a new toothpaste containing a Bio-Descaling Powder (BDP) to see if it can reduce hardened dental plaque (calculus) and gum inflammation. It includes 100 adults with gum disease or who are in a gum maintenance program. Participants brush with either the BDP toothp…

This trial investigates whether surgically removing the primary breast tumor, followed by standard systemic therapy, improves survival compared to systemic therapy alone in women with stage IV breast cancer that has spread only to a single bone site. The study enrolls women aged …

This study tests an experimental oral drug called JAB-8263 in adults with active rheumatoid arthritis. The goal is to see if it is safe and can reduce joint inflammation and pain. Participants take the drug or a placebo every other day for 28 days. The trial is small and early-st…

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula o…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This study tests whether taking a daily antibiotic (levofloxacin) can safely reduce infections in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) who are receiving chemotherapy as outpatients. The trial will randomly assign 75 participants to either lev…

This study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers. About 450 adults with myeloid cancers who have signs of disease before transplant will be assigned to treatment …

This study tests a new medicine called CBT005, a healing protein injected directly into damaged spinal discs. The goal is to see if it is safe and can reduce long-term back pain in 60 adults with disc degeneration. Participants get one injection and are followed for up to 3 years…

This study will compare two materials used for the caps that attach dentures to dental implants: acetal resin and nylon. The goal is to see which one causes less bone loss around the implants and keeps gums healthier. Twenty-two people with no teeth in their lower jaw will be enr…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This trial tests a highly targeted radiation technique called stereotactic body radiotherapy (SBRT) against standard radiotherapy for people whose cancer has spread to the spine but has not yet compressed the spinal cord. The goal is to see if SBRT can better prevent tumor growth…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This study looks at whether a higher dose of the blood thinner clopidogrel works better for people with essential thrombocythemia (ET), a rare blood disorder that raises the risk of dangerous blood clots. The standard dose may not work well for many ET patients, so researchers wi…

This study tests whether a supervised resistance exercise program, done for 2 weeks before and 12 weeks after total hip replacement, improves muscle mass and strength in adults aged 60 and older with severe hip osteoarthritis. Participants are randomly assigned to either the exer…

This study will follow about 98 adults with chronic myeloid leukemia who are taking asciminib after other treatments have stopped working. Researchers want to see how many patients achieve a major molecular response (a key sign of disease control) after two years. The goal is to …

This study compares two ways of making dental crowns for back teeth that have had root canals: 3D-printing from a ceramic-filled resin versus milling from a ceramic block. Sixty adults will receive one of these crowns and be checked for fractures, fit, and color over two years. T…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study tests whether giving a combination of anlotinib (a targeted therapy) and epirubicin (chemotherapy) before surgery can improve outcomes for people with advanced sinonasal adenoid cystic carcinoma, a rare and aggressive cancer of the nasal cavity and sinuses. About 76 pa…

This early-stage study tests a new tablet, FXS0683, in 228 adults with blood cancers like lymphoma or leukemia that returned or didn't respond to standard therapy. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will be clo…

This study tests a reduced-intensity chemotherapy combination (fludarabine and treosulfan) before a half-matched stem cell transplant in 77 older or frail adults with AML. The goal is to see if this gentler regimen can control the leukemia long-term while being safe enough for pa…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers wi…

This study compares two treatments for repairing bone damage from advanced gum disease. About 40 adults with deep gum pockets will receive either a combination of hyaluronic acid and polynucleotides (Regenfast) or enamel matrix proteins (Emdogain), both with a bone graft material…

This trial looks at whether children with cancer who develop a fever and low white blood cells can safely stop antibiotics earlier than usual. About 136 children will be randomly assigned to either stop antibiotics within 24 hours or continue standard treatment. The goal is to se…

This study looks at how much denture teeth wear down over two years in people who have no natural teeth. It compares three types of teeth made with modern digital methods: 3D-printed, milled from a block, and standard prefabricated ones. The goal is to see which type resists wear…

This study follows 150 people who received a BDyn spine implant for degenerative disc disease to see how many need additional surgery at the level above the implant over at least 4 years. Participants will complete surveys, undergo imaging, and report any side effects. The goal i…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This study looks at whether patients with a rare nasal cancer (sinonasal adenoid cystic carcinoma) can safely avoid radiation after surgery if the tumor was completely removed. About 200 patients will choose either surgery alone or surgery plus radiation, and researchers will tra…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This study tests whether a combination of three chemotherapy drugs (thiotepa, busulfan, and fludarabine) given before a stem cell transplant can help older adults with acute myeloid leukemia stay in remission longer. About 93 patients aged 55 to 75 who are in their first remissio…

This study will test a new injectable tooth filling material against a standard one for fixing cavities between baby molars in children aged 3 to 8. Fifty kids will get one of the two fillings, and dentists will check how well they hold up over a year. The goal is to see which fi…

This study tests a stem cell transplant from a matched sibling donor combined with special immune cells (regulatory and conventional T cells) for people with high-risk acute myeloid leukemia (AML). The goal is to prevent the cancer from coming back. About 28 participants will rec…

This study compares mustard gel, made from black mustard seeds, to a standard dental material (MTA) for treating deep cavities in baby molars. 72 children aged 6-8 will receive one of the two treatments after the damaged nerve is removed. The goal is to see if mustard gel can kee…

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This study tests whether giving radiation early to bone spots where cancer has spread can prevent complications like fractures or spinal cord pressure. About 90 adults with solid cancers that have spread to up to five bones will either get standard care or standard care plus radi…

This small study tests a dental implant technique that leaves a piece of the natural tooth root (socket shield) and uses a mix of growth factors and bone graft material to support the implant. Seven adults needing a front tooth implant will be followed for 6 months to check bone …

This study will compare Bioflx crowns (a newer, tooth-colored material) with standard stainless steel crowns for children aged 6 to 9 who have had pulp treatment on their back baby teeth. The goal is to see how each crown affects bite force and the space between teeth, and how sa…

This study tests a dental implant procedure for people with thin jawbone. Surgeons will place the implant and use the patient's own bone chips and special growth factor membranes to rebuild the bone around it. The study will check bone density and gum thickness before, right afte…

This study tests a new way to place dental implants by combining a technique called socket shield (which saves a piece of the tooth root) with concentrated growth factors made from the patient's own blood. The goal is to see if this helps preserve bone and improve implant stabili…

This study tests whether a combination of three drugs (chidamide, venetoclax, and azacitidine) can help prevent acute myeloid leukemia (AML) from coming back in patients who have already achieved remission. About 104 adults aged 18 to 80 will receive up to 12 cycles of treatment.…

This early-phase trial tests a new cell therapy called ThINKK in 12 children aged 2–12 who have had a stem cell transplant for leukemia or neuroblastoma. The therapy is designed to boost the body's natural killer (NK) cells to better fight cancer. The main goals are to check if t…

This study tests a new bone graft putty (MagnetOs Putty) against the standard method of using the patient's own bone to help the spine fuse after scoliosis surgery. About 140 teens and young adults with idiopathic scoliosis will take part. The goal is to see if the putty leads to…

This study tests a dental implant technique that keeps a small piece of the natural tooth root to help preserve bone. It combines this with a special blood-derived growth factor and a bone graft material. Seven adults needing a front tooth implant will be followed for 6 months to…

This study tests whether a treatment using special viruses (called phages) can safely and effectively treat infections in hip or knee replacements caused by Staphylococcus aureus bacteria. About 100 adults will receive either the phage therapy or a placebo during a standard surge…

This study tests a combination of three drugs (venetoclax, homoharringtonine, and azacitidine) plus a growth factor (G-CSF) in 61 older or frail adults with newly diagnosed acute myeloid leukemia (AML) who cannot tolerate standard intensive chemotherapy. The goal is to see if thi…

This study tests whether an antibiotic paste (LSTR) works as well as the standard filling (ZOE) for treating infected baby molars in children aged 4 to 10. 180 kids will be randomly assigned to one treatment and checked after 6 months for healing. The goal is to find a simpler, e…

Researchers at Assiut University are testing whether a specialized MRI technique called multi-echo fast field echo (mFFE) can detect cortical bone changes in knee osteoarthritis as accurately as CT scans. The study enrolls 80 adults aged 40 and older with suspected or confirmed k…

Doctors often wait days for genetic tests to classify acute myeloid leukaemia (AML) and guide treatment. This trial tests whether breath analysis can detect metabolic products from leukaemia and classify the disease faster. Participants give breath samples and extra blood tests d…

This study will test a 4D virtual simulator called Modjaw to see if it helps doctors diagnose temporomandibular joint (TMJ) disorders more accurately. About 20 adults with suspected disc displacement will use the device, and the results will be compared to MRI scans. The goal is …

Researchers are testing whether a smartphone app called DETECTRA can help doctors diagnose rheumatoid arthritis earlier in adults who have joint symptoms and a positive ACPA blood test. Participants are randomly assigned to receive standard care alone or standard care plus the ap…

Researchers are testing a device called BlueCheck to see if it can reliably find early enamel lesions and track how they change over 12 weeks. Participants aged 13 and older with active enamel lesions but no cavities needing immediate fillings receive high-fluoride toothpaste and…

This study investigates whether triphasic bone scans combined with SPECT/CT can accurately diagnose osteoarthritis in the foot and ankle, using MRI as the gold standard. Researchers will compare the imaging results from 40 adults with chronic foot or ankle pain to see how well th…

This study aims to develop a new blood test that could replace the invasive bone marrow biopsy currently used to diagnose myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will collect blood samples from 500 adults with suspected or confirmed MPN and anal…

This pilot study tests a handheld, AI-powered ultrasound device to screen newborns for developmental dysplasia of the hip, a condition where the hip joint doesn't form properly. Researchers will scan babies before they leave the hospital and compare those results with a standard …

This study tests whether a newer ultrasound technique, shear wave elastography, can better detect inflammation at tendon and ligament attachment sites (entheses) in people with psoriatic arthritis compared to standard ultrasound. Researchers will compare imaging results from 60 p…

This trial is testing a new wireless, non-invasive device that measures muscle activity on the back to monitor scoliosis in adolescents. The device uses skin electrodes to detect imbalances in muscle activation on each side of the spine during sitting and movement. The goal is to…

This study tests whether combining two screening questionnaires with a musculoskeletal ultrasound can detect spondyloarthritis—a type of inflammatory arthritis—in people who already have inflammatory bowel disease (IBD) but have not been diagnosed with arthritis. Two hundred adul…

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study explores using millimeter-wave radar and artificial intelligence to detect early signs of scoliosis by analyzing a person's gait. About 200 children and adults with suspected scoliosis will walk in front of a radar sensor, and the AI will compare its findings to standa…

This study tests whether a special MRI sequence, called 'pseudo-scanner,' can accurately map bone tumors and guide surgery, potentially replacing CT scans. About 122 people with bone sarcoma who need surgery will participate. If successful, this approach could reduce patients' ex…

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

Researchers are testing whether removing a specific type of immune cell, called CD45RA-positive naive T cells, from donor stem cells can prevent graft-versus-host disease in older adults undergoing stem cell transplants for acute leukemia or myelodysplastic syndrome. The trial en…

Researchers in Suzhou, China, are testing whether a comprehensive oral health program in preschools and primary schools can reduce tooth decay. The program includes lessons on oral hygiene, guided toothbrushing and rinsing practice, and support from teachers and parents. About 2,…

Researchers are studying whether aloe vera mouthwash can prevent or reduce the severity of oral mucositis, a painful mouth sore that often affects people receiving chemotherapy for acute leukemia. The trial compares aloe vera mouthwash plus usual care against usual care alone in …

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This trial tests whether a silver nanoparticle mouthwash can reduce cavity-causing bacteria in children as effectively as chlorhexidine, but without the staining and taste issues. About 96 children aged 6–12 at high risk for cavities will rinse twice daily for 14 days. The study …

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. T…

Researchers test whether a combination of orofacial myofunctional therapy and cervical stabilization exercises can reduce jaw pain and improve function in adults with anterior disc displacement with reduction, a common temporomandibular disorder. The trial enrolls 80 adults aged …

Researchers compare how people with paraplegia perform and feel about four daily tasks when using a self-balancing exoskeleton versus a manual wheelchair. Five participants attend daily sessions where they do tasks like making coffee or brushing teeth with each device. The study …

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This study tests two types of exercise for people with a common knee condition called patellofemoral pain. One group does neuromuscular control exercises (like balance and coordination), the other does muscle strengthening. Researchers will measure pain, function, and movement in…

Researchers are testing whether tranexamic acid, a drug that helps prevent bleeding, reduces blood loss and wound complications during high tibial osteotomy. This surgery realigns bow-legged knees to ease osteoarthritis pain and slow joint damage. The trial enrolls 200 adults wit…

Researchers compare two methods for replacing a missing front upper tooth with an implant right after extraction. One method, the Socket-Shield technique, leaves a thin piece of the tooth root in place to help protect the jawbone and gums. The other method uses the standard appro…

Researchers compare two ways to perform knee surgery for simple problems like meniscal tears, cartilage damage, and loose bodies. One method uses a needle arthroscopy with a 1.9mm camera through tiny openings, and the other uses standard arthroscopy. Adults aged 18 to 65 join the…

This study compares two ways to give steroid medicine to people with chronic sinusitis who have lost their sense of smell due to blocked nasal passages. One group will get standard steroid spray, while the other gets steroid drops placed directly where smell happens. The goal is …

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

Researchers are testing whether a single high dose of psilocybin, given alongside a structured talking therapy called PEARL, reduces depressive symptoms in adults with advanced cancer. The trial enrolls 46 people in Ontario with stage IV solid tumors, sarcoma, melanoma, endocrine…

Researchers are testing whether a single injection of a hyaluronic acid solution into the knee can reduce pain and improve stiffness and function in people with knee osteoarthritis. The trial enrolls about 700 adults aged 40 to 80 who have had knee osteoarthritis symptoms for at …

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

People with spinal cord injuries often rely on a bowel program to manage neurogenic bowel, a condition that makes it hard to control bowel movements. This trial compares three tools used during those programs: a bisacodyl suppository, a mini enema called Enemeez, and a transanal …

Researchers compare three fluoroscopy-guided epidural steroid injection techniques for adults with leg pain from a herniated disc. Ninety-nine participants receive either a high-volume interlaminar injection, a low-volume interlaminar injection, or a transforaminal injection. The…

This study looks at whether using different root canal tools (TruNatomy vs ProTaper Gold) and different sealers (AH Plus vs TotalFill BC) can reduce pain after a root canal. About 144 adults with a tooth infection will take part. They will rate their pain at several times over a …

Anterior cervical discectomy and fusion is a common neck surgery that can leave people with swallowing trouble, weaker breathing muscles, neck pain, and reduced quality of life. This trial tests whether a structured rehabilitation program improves those problems. Sixty adults who…

Researchers are testing whether a wrist nerve block, which uses a local steroid injection to interrupt pain signals, can reduce wrist pain in adults with rheumatoid arthritis. The trial enrolls 180 people with oligoarticular rheumatoid arthritis that affects the wrist. Participan…

Researchers are testing whether EEG brain wave patterns can track how the sedative dexmedetomidine eases pain during total hip replacement surgery. Twenty patients with hip osteoarthritis receive a dexmedetomidine infusion before their spinal anesthesia. The team records brain ac…

Researchers at the University of Iowa are studying people with thin gum tissue who need a gum graft to cover exposed tooth roots. The trial compares two ways of preparing the gum bed before placing a graft: removing all tissue down to the bone, or leaving a thin layer of tissue o…

This trial tests whether adding Mulligan mobilization, a type of hands-on therapy applied to the foot or the pelvis, to a standard hip-knee exercise program can reduce pain and improve function in people with patellofemoral pain and flat feet. Researchers will compare three group…

This trial tests whether adding a nerve block at the back of the knee to the standard adductor canal block reduces pain and opioid use after total knee replacement. Adults scheduled for knee replacement under spinal anesthesia will receive either the standard block alone or the s…

This trial tests whether a home-based strength training program combined with self-management education can reduce symptoms and improve quality of life for people with knee osteoarthritis. Participants aged 45 and older are randomly assigned to either the exercise and education p…

This trial tests whether a toothpaste with calcium sodium phosphosilicate reduces tooth sensitivity better than a regular fluoride toothpaste. About 192 adults with sensitive teeth will brush twice daily for 8 weeks. Researchers measure how teeth respond to a puff of air and a ge…

This trial tests whether colchicine, an anti-inflammatory drug used for gout, can reduce pain after total knee replacement surgery. Adults having knee replacement for osteoarthritis will take colchicine or a placebo for a few days after surgery. Researchers will track pain scores…

This trial tests whether adding pulsed electromagnetic field therapy (PEMF) to standard shock wave therapy eases pain and improves function in adults with tennis elbow, a condition causing pain on the outer side of the elbow. About 70 people with symptoms lasting at least 3 month…

This trial tests whether adding thoracic spine manipulation and instrument-assisted soft tissue mobilization to standard physical therapy helps people with shoulder impingement syndrome. Participants, aged 18 to 55, will receive either conventional therapy alone or conventional t…

This trial tests whether two different collagen supplements can reduce pain, stiffness, and disability in adults with knee osteoarthritis. Adults aged 35 to 65 with moderate knee osteoarthritis will take either a 10-gram hydrolyzed collagen, a 5-gram bioactive collagen peptide, o…

This trial compares two non-invasive treatments for myofascial pain disorder, a common cause of chronic jaw and facial pain. Researchers will give one group low-level laser therapy and another group therapeutic ultrasound, both applied to the masseter muscle. The goal is to see w…

Researchers are testing whether a daily drink containing hyaluronic acid can ease knee pain and improve joint function in adults aged 45 to 80 with mild knee osteoarthritis. Participants will drink either the active beverage or a placebo each day and report their pain levels usin…

This trial tests whether adding virtual reality to Schroth exercises, a standard physiotherapy for scoliosis, improves trunk movement and quality of life in adolescents with moderate curves. Researchers will compare traditional supervised Schroth exercises with two VR-enhanced ve…

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This trial tests whether a single 2-hour online pain skills session, called Empowered Relief, can help adults with subacromial shoulder pain who are following a 12-week exercise program. Researchers want to know if the session reduces unhelpful thoughts and fears about pain, and …

This trial tests whether a daily oral cannabis extract with a 5:1 CBD-to-THC ratio can reduce chronic pain in women aged 45 to 80 who haven't found relief from standard treatments. Participants will receive either the cannabis extract or a placebo in a crossover design, allowing …

This trial investigates whether a single injection of dexamethasone, a steroid, given before a root canal can lower pain during the procedure. It includes adults with severe tooth pain from symptomatic irreversible pulpitis. Participants receive either dexamethasone or a placebo,…

This trial tests whether an 8-week virtual reality-based cognitive behavioral therapy (VR-CBT) program, done at home before elective spine surgery, can improve recovery and quality of life. Adults scheduled for spinal fusion will be randomly assigned to receive VR-CBT plus usual …

This trial tests a method called Active Default to improve supportive care for adults 60 and older starting venetoclax-based therapy for acute myeloid leukemia (AML). Participants complete a geriatric assessment covering mobility, nutrition, mood, memory, and medications. If the …

This study tests whether injecting platelet-rich plasma (PRP) into the epidural space during endoscopic disc herniation surgery can reduce nerve pain in the leg. PRP is made from the patient's own blood and may help healing and reduce inflammation. The trial will enroll 50 adults…

This trial is testing whether a single, higher dose of radiation (8 Gy) can relieve pain from bone metastases as effectively as a standard course of five smaller doses (20 Gy total). The study includes adults with cancer that has spread to the bones and who have significant pain.…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This trial tests whether a structured 12-week physiotherapy exercise program can improve balance, posture, and reduce fall risk in people with osteoporosis. Participants, aged 50 and older, will be randomly assigned to either the exercise program or a control group. The program f…

This trial tests whether duloxetine, an FDA-approved osteoarthritis drug, can improve walking ability and physical activity in people with chronic knee osteoarthritis pain. Participants take duloxetine or a placebo for six weeks, then complete surveys, physical tasks, brain imagi…

This study looks at two ultrasound-guided nerve blocks used to manage pain after lumbar spine surgery: the classic TLIP block and the QIP block. Adults aged 18-65 having elective lumbar discectomy will receive one of these blocks as part of their routine care. Researchers will tr…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This pilot study tests whether playing a collaborative virtual reality game during the first walk after scoliosis surgery can reduce pain and anxiety in teens aged 10 to 17. Half of the participants will use a VR headset to explore a magical jungle with a physiotherapist, while t…

This trial tests whether washing out the jaw joint (arthrocentesis) works as well as Botox injections for treating painful temporomandibular joint (TMJ) disorders. Adults with TMJ pain that hasn't improved with standard care will be randomly assigned to one of the two procedures.…

This trial tests whether flushing the inside of a tooth with cold saline (about 2.5°C) after root canal retreatment can lower pain and inflammation. One hundred adults needing retreatment on a lower premolar will be randomly assigned to receive either cold or room-temperature sal…

This pilot trial tests whether a web-based conversational assistant can help people recovering from total knee replacement. About 60 adults who have had knee replacement surgery will either receive standard care alone or standard care plus access to the online assistant for 6 wee…

Pseudo-angina is chest pain that feels like a heart attack but comes from muscle knots, not the heart. This trial tests whether two hands-on treatments—Graston Technique (using a stainless-steel tool to massage muscles) and local ischemic compression (sustained finger pressure on…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This trial tests whether adding a hands-on technique called manual traction to standard physical therapy can reduce pain and improve function in women recovering from total knee replacement. Forty-eight women aged 50 to 75 with knee osteoarthritis will be randomly assigned to rec…

This study compares two physical therapy approaches for patellofemoral pain syndrome, a common cause of front knee pain. One group performs the Mikhled Knee Exercise Program alone, while the other adds Stecco fascial manipulation, a manual therapy technique. Researchers will meas…

This study tests whether applying myofascial release—a manual therapy that relaxes tight muscles—to the arms can improve sprint speed in wheelchair rugby players with spinal cord injury. Twelve athletes will complete a 20-meter sprint test with and without the therapy on separate…

This study tests whether using a virtual reality (VR) headset during hip replacement surgery can lower anxiety and prevent post-surgery confusion in older adults. Half of the participants will watch calming nature scenes through VR while under regional anesthesia, while the other…

This trial tests whether an injection of tergase (berahyaluronidase alfa) can reduce swelling after total knee replacement surgery. The study involves 30 older adults with severe knee osteoarthritis who are having both knees replaced at the same time. One knee receives the inject…

This study tests whether a 3% hypertonic saline (saltwater) rinse, used at the end of a root canal procedure, can reduce pain and inflammation better than the standard 0.9% saline rinse. Forty adults with painful tooth inflammation will receive one of the two rinses, and their pa…

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This study compares two hands-on physical therapy techniques—popliteus muscle release and patellofemoral mobilization—for treating patellofemoral pain syndrome, a common cause of knee pain. Researchers will measure changes in pain intensity, knee function, and quadriceps strength…

This study compares two treatments for frozen shoulder (retractile capsulitis): a standard steroid injection into the shoulder joint versus that same injection plus a nerve block near the shoulder blade. The nerve block uses a numbing medicine and a steroid to calm the nerve that…

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This study tests whether adding a manual foot massage (plantar fascia release) to standard foot exercises can immediately improve movement quality in young adults with flat feet. Twenty-nine physically active participants aged 18-35 will try both exercise-only and exercise-plus-m…

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests whether the drug zoledronate can reduce pain in children aged 4 to 17 with chronic recurrent multifocal osteomyelitis (CRMO), a rare auto-inflammatory bone disease. The 30 participants have not responded to standard anti-inflammatory drugs. They will receive eith…

This study compares core stability exercises versus proprioceptive (balance) training in 63 adults aged 18-40 with patellofemoral pain syndrome (runner's knee). Participants will be assigned to one of two exercise programs to see which better reduces pain and improves knee functi…

This study will test whether an 8-week yoga program done live over Zoom can improve balance, endurance, and well-being in 32 children aged 8-12 with juvenile idiopathic arthritis (JIA). The yoga sessions are led by certified physiotherapists and include breathing, poses, and medi…

This study tests whether a 12-week program of core and breathing exercises can improve spine curvature, breathing, and appearance in teens aged 10-17 with mild scoliosis (Cobb angle 10-25°). 32 participants will be split into two groups: one doing the special exercises, the other…

This study compares two non-surgical treatments—shockwave therapy and high-power laser—for chronic tennis elbow (lateral epicondylitis) that has lasted over 3 months. Seventy-two adults aged 40-50 will receive one of the treatments plus standard physical therapy. Researchers will…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study tests whether adding neck-strengthening exercises to standard physical therapy can reduce pain and improve shoulder function in people with shoulder impingement syndrome. Forty-two adults with shoulder pain will be split into two groups: one gets standard therapy alone…

This study will follow 300 adults aged 50 and older with knee osteoarthritis who are scheduled for a 3-week thermal spa treatment. Researchers will use wearable sensors to measure knee movement fluidity before and after the spa program, and at 3 and 12 months later. They will als…

This study looks at two ways to help people recover after surgery for a slipped disc in the lower back. One group will start moving early, and the other will do the same plus get mild electrical stimulation on their muscles. The goal is to see which approach reduces pain and impr…

This study tests two simple treatments for tooth sensitivity caused by worn enamel: a blue diode laser and a bioactive glass powder. Thirty adults with two similarly sensitive teeth will each receive both treatments (one per tooth) to see which works better. The goal is to find a…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study compares two physical therapy techniques for athletes with tightness in the back of the shoulder, a common issue in overhead sports like cricket. 34 athletes will receive either Kaltenborn joint mobilization or a specific stretch for 4 weeks. Researchers will measure p…

This study compares two spinal anesthetics, ropivacaine and bupivacaine, in 176 people having hip replacement surgery. The goal is to see which one allows faster return of feeling and movement while still controlling pain well enough for same-day discharge.

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study will test a 16% carbamide peroxide gel used at home in custom trays for 90 minutes daily over six weeks. Ten adults with healthy gums and no prior whitening will have their tooth color measured by a special device and report how their quality of life changes. The goal …

This study tests whether a roller device that delivers essential oils during self-massage can reduce pain and improve function in people with chronic tennis elbow (lasting over 3 months). Eighty adults will use the roller twice daily for 3 months. Researchers will measure pain an…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study looks at whether using a gentle pulling force (mechanical traction) on the knee before or after exercise works better for easing pain and improving movement in people with knee osteoarthritis. Researchers will compare three groups: traction before exercise, traction af…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study compares two types of nerve blocks (thoracolumbar interfascial plane block and retrolaminar block) to see which one helps patients recover better after lumbar spine fusion surgery. 70 adults scheduled for surgery will receive one of the two blocks before the procedure.…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study tests whether a newer bioceramic filling material reduces pain after root canal treatment better than the standard calcium hydroxide filling. Twenty-eight adults with painful lower molar infections will receive one of the two fillings during their root canal. Pain leve…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

This study tests whether a gel made from hyaluronan (HA35) can safely reduce gum pain and swelling after dental procedures. About 30 adults will chew on gel-soaked cotton balls for 30 minutes. Researchers will measure pain and swelling changes at 1, 30, and 60 minutes after appli…

This study looks at three different ways to manage pain during and after hip replacement surgery in people aged 60 and older. All participants will get spinal anesthesia, but some will also get a nerve block around the hip joint, with or without an extra anti-inflammatory drug. T…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This study tests two ways to numb the knee after total knee replacement. One method uses a low-dose anesthetic on three main nerves, while the other uses a higher dose on two smaller nerves. The goal is to see which provides better pain relief with less muscle weakness, so patien…

This study tests whether wearing a custom-made back brace, along with standard care like physical therapy, can reduce low back pain in adults with degenerative scoliosis (a curved spine that causes pain). About 130 people aged 40 to 75 with moderate to severe pain will be randoml…

This study compares two surgical treatments for thumb arthritis: a prosthetic joint replacement (arthroplasty) versus removal of a small bone at the thumb base (trapeziectomy). Researchers will enroll 64 adults aged 18-69 with thumb arthritis that hasn't improved with non-surgica…

This study compares a specialized posture-correction exercise program (Mirror Image Spine Correction) with standard physiotherapy for adults with sciatica. Over 12 weeks, 64 participants will receive supervised sessions three times per week. The main goal is to see if the new exe…

This study tests whether gently rocking in a chair three times a day for 30 minutes helps people aged 65 and older recover after hip replacement surgery. Sixty participants will be randomly assigned to either rock or sit still in a chair. Researchers will measure how many people …

This pilot study will test whether a device that sends magnetic pulses to the arm can reduce pain in people with tennis elbow, golfer's elbow, or carpal tunnel syndrome. About 40 adults will receive either real or fake (sham) stimulation over two days. Researchers will measure pa…

This study looks at whether a specific hip stretching technique can reduce back disability and pain in people with spondylolisthesis, a condition where a spine bone slips forward. Researchers will measure disability, pain, and how well the lower back bends. The study plans to inc…

This study tests whether applying a dipotassium oxalate gel before placing a filling can reduce tooth sensitivity afterward. 64 adults with sensitive tooth cavities will be randomly assigned to get the gel or standard treatment. Pain is measured at 24 hours, 7 days, and 30 days u…

This study tests whether a special glass-based bone cement, used with ultrasound during surgery, can safely stabilize bones and reduce pain in people with advanced cancer that has spread to the pelvis. Eight adults aged 18 to 80 with painful pelvic bone tumors will receive the tr…

This study compares two minimally invasive procedures to relieve long-term knee pain from osteoarthritis. One uses radiofrequency (heat) to block pain nerves, the other uses a small amount of alcohol. About 50 adults aged 45-85 with moderate to severe knee pain will be randomly a…

This study looks at whether doing physical therapy in the daytime or evening helps people with a herniated disc in their lower back sleep better and feel less sleepy during the day. It includes 60 adults who also have a high risk for obstructive sleep apnea. Participants will be …

This study tests whether a 12-week personalized exercise program can reduce fatigue and improve physical function in people with myeloproliferative neoplasms (MPN) and chronic myeloid leukemia (CML). Participants will do supervised aerobic and resistance training twice a week plu…

Researchers at Marmara University are studying whether alexithymia, a trait where people struggle to identify and describe their feelings, relates to pain intensity, quality of life, anxiety, depression, and childhood trauma in adults with chronic coccydynia. Participants have ha…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…

Researchers want to know whether caffeine consumption is linked to irregular heartbeats and daily physical activity in adults with heart failure, reduced left ventricular ejection fraction, and an implantable cardioverter-defibrillator (ICD). About 170 participants fill out a one…

Many older adults with knee osteoarthritis believe their pain comes mainly from joint wear and tear, which can lead to fear of movement and less activity. Researchers at McMaster University are comparing two web-based education programs: one that explains pain as a mix of biologi…

Researchers at the University of Minnesota are studying why chronic pain varies so much from person to person. The study enrolls 400 adults with chronic low back pain or spinal cord injury-related neuropathic pain. Participants answer brief surveys four times a day for at least t…

This observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…

Researchers at the University of Reading are studying how sleep and pain relate in adults with hip or knee osteoarthritis. Participants wear a wrist sleep monitor for seven days and nights while answering daily questions about sleep, pain, and mood. The team compares reported sle…

This pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…

This study looks at three different ways to clean infected root canals in 66 men aged 18-35. The goal is to see which method best reduces signs of inflammation and infection. Researchers will measure certain proteins in the fluid around the tooth root before and after treatment.

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

Researchers are comparing two common types of total shoulder replacement, anatomic and reverse, in adults who already had the surgery. The study tracks patient-reported pain and function scores, complications, and revision surgeries for three years. They also check how often the …

Researchers at Assiut University are studying whether metabolic syndrome, a cluster of conditions like high blood pressure and high blood sugar, relates to the clinical course of chronic Philadelphia-negative myeloproliferative neoplasms. These are rare blood cancers where the bo…

Researchers at Sohag University are following 50 children under 18 who have systemic juvenile idiopathic arthritis, a rare inflammatory disease that affects the whole body. The study records each child's symptoms, lab results, complications, and the treatments they receive, inclu…

Researchers want to understand how people with patellofemoral pain respond to resistance training taken to muscular failure. About 30 participants aged 15 to 35 with pain in one knee will perform a knee exercise until they cannot continue or their pain reaches a moderate level. T…

Researchers are taking a blood sample from one child with Hutchinson-Gilford progeria syndrome, a rare condition that causes rapid premature aging. They plan to turn those blood cells into stem cells and then into disease-relevant cells like muscle and nerve cells. This lab model…

Researchers are testing whether people with rheumatoid arthritis have early, symptom-free kidney problems more often than healthy people of the same age and sex. The study compares kidney function and urine protein levels between 120 participants, including those with rheumatoid …

Researchers at Assiut University are studying whether rheumatic diseases such as rheumatoid arthritis, lupus, and Sjogren's syndrome harm the meibomian glands, the tiny eyelid glands that keep tears from evaporating. The study compares 120 people with these conditions to 30 healt…

Researchers at Assiut University Hospitals are studying whether three blood measures predict survival in adults newly diagnosed with non-M3 acute myeloid leukemia. The measures are the ratio of C-reactive protein to albumin, the ratio of albumin to fibrinogen, and the level of fe…

Researchers are observing patients in China who have both a tumor in the sellar region of the brain and an unruptured intracranial aneurysm. The study compares three approaches: removing the tumor before treating the aneurysm, treating the aneurysm before removing the tumor, or r…

This study aims to understand why some teeth fail to erupt (come in) properly. Researchers will look at dental records and test for changes in the PTH1R gene in 50 patients with eruption problems. The goal is to improve diagnosis and distinguish between different causes, such as …

Researchers at Akdeniz University are studying how adolescent idiopathic scoliosis, a sideways spine curve, affects the muscles along the spine and overall posture. They will compare teens with scoliosis who wear a back brace, those who do not, and healthy teens. Using surface el…

This study looks at how levels of immune-signaling molecules called cytokines change in the blood just before and after a stem cell transplant. Researchers want to see if these patterns differ based on the patient's disease, such as myelofibrosis or acute leukemia, and the type o…

This study looks at blood cancer patients who carry drug-resistant bacteria in their gut. Researchers want to find out who is most likely to get a serious infection from these bacteria. They will collect rectal swabs and track patients for 90 days to build a prediction tool. The …

Researchers at Sohag University are studying 150 people with rheumatoid arthritis to see whether the Rheumatoid Arthritis Impact of Disease (RAID) questionnaire can reliably detect disease flares. They will compare the questionnaire's performance with other standard disease activ…

This study explores whether patients with acute myeloid leukemia can receive intravenous cytarabine chemotherapy at home instead of in the hospital. Researchers will track how many patients complete the planned home treatment, how often doses are given at home versus the hospital…

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This study looks at how often nociplastic pain, a type of pain caused by altered nerve processing rather than tissue damage, occurs in people with subacromial pain syndrome (SAPS). Researchers will examine 400 adults aged 18 to 70 with shoulder pain lasting at least 3 months. Par…

This study follows 134 adults with subacromial pain syndrome, a common cause of shoulder pain. All receive a routine corticosteroid injection into the shoulder as part of usual care. Researchers test whether people with a nociplastic pain phenotype, a type of pain processing that…

Researchers at Sohag University are comparing levels of a long non-coding RNA called GAS5 and a blood protein called IL-6 in people with rheumatoid arthritis versus healthy individuals. The study will measure GAS5 expression in blood samples using a technique called qRT-PCR and c…

This study looks at whether a blood protein called asprosin is linked to metabolic syndrome and heart risk in people with rheumatoid arthritis. Researchers will compare asprosin levels in three groups: rheumatoid arthritis patients with metabolic syndrome, those without it, and h…

Researchers at Assiut University are studying how psoriatic arthritis affects patients' daily lives and whether that impact matches clinical signs of disease activity. Adults with psoriatic arthritis will complete the Arabic version of the PsAID-12 questionnaire, which covers pai…

This study explores the communication challenges faced by healthcare providers when caring for non-verbal patients in intensive care, such as those with spinal cord injury or a tracheostomy. Researchers will interview nurses and speech-language pathologists, then survey a larger …

Researchers are measuring how often subclinical hypothyroidism, a mild form of underactive thyroid, occurs in people with rheumatoid arthritis compared to healthy people. They will also check whether this thyroid condition relates to higher disease activity or more severe joint i…

This early-phase study at St. Jude Children's Research Hospital will test whether it is safe and possible to collect blood stem cells from 12 young adults with inherited bone marrow failure syndromes. Participants will receive two drugs (filgrastim and plerixafor) to move stem ce…

This trial tests whether an extra consultation using a predictive tool, called Dialogue Support, helps adults scheduled for lumbar spine surgery understand their likely outcomes. The tool estimates how a patient may fare one year after surgery and presents that information visual…

This study looks at whether changes in regulatory T cells (a type of immune cell) after facial reconstruction surgery can predict how quickly patients heal and how long they stay in the hospital. Researchers will collect blood samples from about 60 adults before, during, and afte…

This study uses ultrasound to examine the joints of adults with mild hemophilia, a group that often goes understudied. Researchers will scan six joints (ankles, knees, elbows) to look for early signs of damage that may not cause symptoms yet. The goal is to see how common joint p…

This study compares sleep quality between adolescents with idiopathic scoliosis and healthy peers of similar age and sex. Researchers will use questionnaires to assess sleep, and in the scoliosis group, they will also look at curve severity, pain, body image, and brace use. The g…

This study investigates whether the thickness of fat over the shin bone, measured on a standard knee X-ray, is a better predictor of infection after total knee replacement than Body Mass Index (BMI). Researchers will review data from 400 adults who had knee replacement surgery, c…

This study explores whether a digital tool can help monitor adults with chronic myeloid leukemia who have stopped treatment for up to two years. Over 12 months, researchers will track how often patients use the tool, aiming for a usage rate of at least 60%. The goal is to see if …

This study will test two different levels of positive pressure (PEEP) on a breathing machine during lumbar spine surgery performed face-down. The goal is to see which setting helps patients breathe better and maintain good oxygen levels. Sixty adults aged 18-65 having elective ba…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study is translating and testing an Italian version of a questionnaire that measures kinesiophobia—the fear of movement—in people with temporomandibular disorders (TMDs), which affect the jaw joint and muscles. Researchers will ask 250 adults diagnosed with TMD to complete t…

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This study investigates how to engineer T cells to more effectively target acute myeloid leukemia (AML). Researchers will analyze samples from healthy donors and AML patients to identify T-cell receptors that recognize leukemia cells. The goal is to create next-generation enginee…

This study looks at how a procedure called temporomandibular joint arthrocentesis—a washout of the jaw joint—affects the masseter muscle, a key chewing muscle. Researchers will use ultrasound and strain elastography to measure the muscle's thickness and elasticity before and afte…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This quality improvement initiative tests whether a standardized electronic medical record template for progress notes, combined with a pharmacist-led medication titration service, can improve the management of polycythemia vera (PV). The study enrolls hematologists and oncologis…

This study investigates what factors — such as pain intensity, fear of movement, and confidence in managing pain — influence how adults with chronic tennis elbow perceive their illness and what they expect from treatment. Researchers will survey 137 participants and analyze the d…

This study compares two approaches for runners with flat feet (pes planus): custom foot orthoses versus an eight-week foot-core strengthening program. Researchers will measure how each intervention affects hip, knee, and ankle motion during a prolonged run. The goal is to underst…

This study tracks how Sanfilippo syndrome type C, a rare genetic disorder that affects the brain, progresses over time. Caregivers of children and young adults aged 1 to 25 will record videos of daily activities and answer questionnaires using a smartphone app every six months fo…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study looks at how aerobic exercise influences pain processing in people with chronic jaw pain (TMD). Researchers will compare pain responses among three groups: patients with jaw pain, inactive healthy people, and healthy endurance athletes. The goal is to understand if exe…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This study looks at people who had treatment for peri-implantitis—an infection around dental implants—between 5 and 23 years ago. Researchers will check gum health, bone levels, and other signs to see which surgical or non-surgical approaches worked best over the long term. The g…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study is testing whether a blood test can locate where colorectal cancer has returned or spread after surgery. Researchers are analyzing genetic markers in the blood to build a model that predicts whether a recurrence is local or distant. The goal is to improve early detecti…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study will test whether artificial intelligence programs like ChatGPT can interpret brain monitoring data (BIS) as accurately as experienced clinicians during spine surgery. Researchers will compare AI responses to those of two doctors in 63 patients. The goal is to see if A…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study looks at how to safely place a breathing tube in people with acromegaly, a condition that can cause changes in the face and airway. It compares two methods: direct laryngoscopy and video laryngoscopy. The goal is to find which method gives a better view of the airway a…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study will observe 10 adults with acute myeloid leukemia who are receiving the drug gilteritinib after a stem cell transplant. Researchers want to understand how gilteritinib affects the behavior, metabolism, and function of immune cells like T-cells and monocytes. The goal …

This study aims to create a score that uses a special blood test to predict bleeding risk in people with blood cancers and very low platelet counts. Researchers will take an extra blood sample from 410 participants and analyze it with viscoelastometric tests. The goal is to ident…

This study looks at skull bone samples from 80 infants aged 3 to 12 months who have craniosynostosis, a condition where skull bones fuse too early. Researchers will measure the bone's strength, structure, and tissue makeup both near and far from the fused area. The goal is to bet…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study will look at whether SPECT scans taken after Lu-PSMA therapy can help predict how well patients with metastatic castration-resistant prostate cancer (mCRPC) are doing. Researchers will measure tumor activity and volume on the scans and compare them to standard PET-base…

This study looks at 80 people having hip or knee replacement surgery to compare two ways of giving a drug called tranexamic acid, which helps reduce bleeding. Half will get the drug through a standard IV, and the other half will get it injected into the bone. Researchers will mea…

This study looks at how knee pain intensity relates to the knee's ability to sense its own position (proprioception) in people with patellofemoral pain syndrome. Researchers will measure pain and joint position error during a single-leg squat in 82 adults aged 18–35. The goal is …

This study looks at how often muscle weakness and loss (sarcopenia) happens in people aged 15 to 40 with juvenile idiopathic arthritis. Researchers will measure grip strength, do body scans, and use questionnaires to check muscle health. The goal is to find out how common this pr…

This study tests how well three different toothpastes repair early tooth damage (enamel lesions) in 30 healthy adults aged 18-70. Participants wear a removable mouth device with human enamel pieces for 14 days per toothpaste, with breaks in between. Researchers measure mineral ga…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study is testing a new blood test called AlloHeme that looks for tiny traces of a patient's own cells after a stem cell transplant. The goal is to see if the test can predict whether leukemia or MDS will come back before it happens. About 400 adults who have had or will have…

This study will explore if menopause and blood sugar levels are linked to frozen shoulder in women. Researchers will survey women who have had frozen shoulder and closely monitor a smaller group of perimenopausal women with and without the condition. The goal is to understand why…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This study translates the Foot Posture Index (FPI-6), a tool that checks foot shape while standing, into Spanish and tests if it works well. About 100 people aged 6 to 89 will take part. The goal is to give Spanish-speaking doctors and researchers a reliable way to assess foot po…

This study will look at how jaw bone quality changes over time in patients with medication-related osteonecrosis of the jaw (MRONJ), a side effect of drugs like bisphosphonates. Researchers will analyze existing CBCT scans from 25 adults to measure bone density and structure at d…

This study will track sleep patterns in 20 people before and after reverse shoulder replacement surgery. Participants will wear a MotionWatch 8 sleep tracker for a week before surgery and again 6 months after. The goal is to see if better sleep is linked to better recovery and sh…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study looks at whether a specially trained physical therapist can diagnose jaw disorders (like TMJ) as accurately as an oral surgeon. 70 people with jaw pain will be checked by both a physical therapist and a surgeon, and their diagnoses will be compared. The goal is to see …

This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagn…

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether …

This study looks at chronic sinusitis with nasal polyps, a condition causing long-term nasal congestion and breathing problems. Researchers will measure inflammation markers and examine nasal tissue from 10 adults using a steroid spray (budesonide). The goal is to better understa…

This observational study will measure two substances in the blood—COMP and MMP-3—in 60 people with knee osteoarthritis and healthy controls. Researchers want to see if these markers relate to pain, function, and X-ray findings. No treatment is given; the goal is to better underst…

This study follows 60 adults with hand or upper limb injuries to see if improvements in the first weeks of rehab can predict function months later. A digital tool created by a therapist tracks progress and patient feedback. The goal is to help clinicians make better, data-driven …

This study will follow 100 adults with knee arthritis who are scheduled for knee replacement surgery. Researchers will measure how changes in the shape of the knee bones after surgery affect how well the knee bends and how much pain patients feel. The goal is to find the best ali…

This study will measure two proteins (myostatin and irisin) in the blood of 60 postmenopausal women aged 50-65. Researchers will group participants by bone density (normal, low, or very low) and test their muscle strength. The goal is to see if these proteins are linked to bone a…

This study looks at how many days of bed rest are best after a specific type of brain surgery done through the nose. About 316 adults having this surgery will be placed into groups with different bed rest times (0, 1, 2, or 3 days). The goal is to see which rest period leads to t…

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…