Electric belly zaps may help spinal cord injury patients cough better
NCT ID NCT07626931
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucus and reduces lung infections like pneumonia.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Respiratory Muscle Stimulator (device)
- What this could lead to
- If it works, this could provide a non-drug way to strengthen cough and reduce pneumonia risk in people with spinal cord injury.
- What could go wrong
- This is an early-stage trial with 150 participants, so results may not apply to everyone. The device may not improve cough enough to prevent complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults (≥ 22 years of age) admitted to rehabilitation with a new SCI. 2. New non-progressive SCI occurring in the past 3 to 8 weeks. 3. Neurological level of injury of C1-T5. 4. American Spinal Injuries Association Impairment Scale A to C. 5. CPF of \<160 L/min (Note: A CPF of \<270 L/min has been shown to be associated with decreased secretion clearance and increased respiratory complications, while a CPF of \<160 L/min has been shown to lead to an ineffective cough). 6. Not dependent on mechanical ventilation (people dependent on mechanical ventilation are at greatly increased risk of respiratory complications and are excluded due to this heterogeneity). 7. Able to sit upright. 8. Expected to remain in rehabilitation for at least another 3 weeks. Exclusion Criteria: 1. Respiratory complications in previous 24 hours (screening out iatrogenic complications). 2. Chronic respiratory disease. 3. No contraction of the abdominal wall muscles in response to abdominal NMES. 4. Open abdominal surgery ≤ 4 weeks prior to enrollment. 5. Have yet to undergo spinal surgery to stabilize injury, where required. 6. Body mass index \>40 kg/m2. 7. Pacemaker (external or internal) or implanted electronic device (e.g., a defibrillator). 8. Known or expected to be pregnant. 9. Placed on a palliative/supportive care only pathway. 10. Receiving any of the following as standard of care: * Abdominal FES * Inspiratory or Expiratory muscle training * Transcutaneous or implanted thoracolumbar spinal stimulation 11. Participating in any of the following: * A study with the same or similar primary endpoint * A study investigating electrical stimulation or respiratory muscle therapy * Any study in which the investigator determines may interfere with the results of this study 12. Unable or unwilling to comply with protocol requirements, including assessments, tests, and follow-up visits including facial or dental trauma. 13. Any other medical condition which in the opinion of the Investigator will make participation medically unsafe or interfere with the study results. 14. Unable to provide informed consent. 15. Unwilling to provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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