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Running with knee arthritis: friend or foe? new study investigates

NCT ID NCT07528885

Knowledge-focused Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether running is safe and beneficial for people with knee arthritis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gradual running program
What this could lead to
If successful, this study could clarify whether running is safe for people with knee osteoarthritis, helping guide exercise recommendations.
What could go wrong
This is a small, early-stage observational study with only 80 participants. It measures cartilage changes on MRI, not clinical outcomes like pain or function, so results may not directly translate to real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria (all): * have been running consistently for no more than six months at time of enrolment, with a cumulative weekly volume of less than 5 kilometres OR have yet to take up recreational running consistently * are comfortable running and walking on a treadmill for at least 30 minutes Inclusion criteria (knee osteoarthritis (OA) group): * have definitive knee OA as diagnosed using x-rays * report having experienced frequent knee pain over the past 3 months Inclusion criteria (Control group): * have no evidence of knee OA based on x-rays * have had pain-free knees for at least the past 3 months Exclusion Criteria (all): * have an inflammatory arthritic condition (e.g. gout or rheumatoid arthritis) * have a presence of any health condition (other than OA in the knee OA group) affecting normal movement or that precludes engaging in moderate to high impact activities such as running Additionally, exclusion criteria based on MRI safety: * cannot safely fit into the MRI scanner * presence of metallic implants (including pace makers, brain aneurysm clips, stents, cochlear implants, artificial heart valves, and prostheses) * recent surgery or tattoos within the past 6 weeks * current or possible pregnancy * electrical stimulator for nerves or bones * infusion pumps * shrapnel or other metallic fragments * non-removable metallic jewellry

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Conditions

The condition(s) this trial relates to.

Motor Activity osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis (OA) of the knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Motion Analysis and Biofeedback Laboratory, The University of British Columbia

    Vancouver, British Columbia, V6T 1Z3, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.