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Thumb arthritis surgery showdown: which operation offers faster relief?

NCT ID NCT07552831

Symptom relief Sponsor: Sahlgrenska University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical treatments for thumb arthritis: a prosthetic joint replacement (arthroplasty) versus removal of a small bone at the thumb base (trapeziectomy). Researchers will enroll 64 adults aged 18-69 with thumb arthritis that hasn't improved with non-surgical treatments. Participants will be randomly assigned to one of the two surgeries and followed for up to 10 years to track pain, function, and implant durability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgery (prosthetic joint replacement or bone removal)
What this could lead to
If successful, this could show that prosthetic joint replacement offers faster pain relief and better function than the standard bone-removal surgery for thumb osteoarthritis.
What could go wrong
This is a small, early-stage trial with only 64 participants, so results may not apply to everyone. Prosthetic implants can loosen or fail over time, requiring additional surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2038

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pain at the base of the thumb affecting activities of daily living and insufficient response to at least 3 months of non-operative treatment (orthosis, non-steroidal anti-inflammatory drugs, and/or corticosteroid injections). * Radiographic thumb carpometacarpal osteoarthritis, Eaton grade 2-3. * For Eaton grade 2, age ≥50 years. * Age 18-69 years. * Provision of written informed consent. Exclusion Criteria: * Symptomatic osteoarthritis of adjacent joints (e.g., scaphotrapeziotrapezoid joint, STT-joint). * Need for concurrent surgery in the metacarpophalangeal joint (e.g. arthrodesis or capsulodesis). * Post-traumatic thumb carpometacarpal osteoarthritis. * Previous surgery for thumb carpometacarpal osteoarthritis in the contralateral hand. * Inflammatory arthritis (e.g., rheumatoid arthritis or systemic lupus erythematosus). * Osteoporosis/osteopenia of such severity that secure cup placement in the trapezium is not possible (for arthroplasty). * Ongoing systemic corticosteroid treatment. * Other hand surgical condition in the same hand that could confound outcomes (e.g., carpal tunnel syndrome or de Quervain tenosynovitis). * Cognitive impairment preventing reliable participation. * Ongoing, or suspected ongoing, alcohol or drug misuse. * Insufficient Swedish language proficiency to complete the questionnaires.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hand

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thumb osteoarthritis

How to take part

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  1. The official record

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    Open the record ↗

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More trials for these conditions

Other studies related to the condition(s) this trial covers.