Dental detectives: scientists analyze tooth pulp to improve diagnosis of toothaches
NCT ID NCT07533396
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagnostic methods accurately reflect the true state of the pulp, and to find biomarkers that could help dentists make better treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could lead to better diagnostic tools for dentists to decide when to preserve or remove tooth pulp, improving treatment outcomes.
- What could go wrong
- This is an observational study, not a treatment trial. It may not directly change clinical practice, and results may not apply to all patients.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients (≥18 years old) whose pulp tissue must be removed during routine dental care, either through endodontic treatment or tooth extraction for orthodontic, surgical, prosthetic, or periodontal reasons. \- Patients who have been informed about the study and have not expressed opposition to participation
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \- Adult patients (≥18 years old) whose pulp tissue must be removed during routine dental care, either through endodontic treatment or tooth extraction for orthodontic, surgical, prosthetic, or periodontal reasons. * Patients who have been informed about the study and have not expressed opposition to participation Exclusion Criteria: * \- Patients who have taken anti-inflammatory medication within 12 hours prior to the dental procedure. * Patients under legal protection measures (e.g., guardianship or curatorship).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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