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Knee pain relief: targeted exercises show promise in small trial

NCT ID NCT06893289

Symptom relief Sponsor: Universidade do Porto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 18, 2026 · Updated 5 times

Summary

This study tests two types of exercise for people with a common knee condition called patellofemoral pain. One group does neuromuscular control exercises (like balance and coordination), the other does muscle strengthening. Researchers will measure pain, function, and movement in 24 adults over 6 weeks. The goal is to see if matching the right exercise to the right patient leads to better results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise (neuromuscular control exercises and muscle strengthening)
What this could lead to
If successful, this could point toward more targeted exercise treatments for specific types of knee pain.
What could go wrong
This is a very small, early-stage study with only 24 participants, so results may not apply to everyone. It also compares two exercise types, not a drug or device, so the benefit may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Men and women aged 18-40 years old that can give informed written consent. Clinical diagnosis of unilateral or bilateral PFP longer than 3 months (exemplified in the following sections). Anterior or retropatellar pain reported on at least two of the following activities: prolonged sitting, ascending or descending stairs, running, kneeling and hopping/jumping. At least two of the three following clinical examination findings: * Pain during resisted isometric quadriceps contraction * Pain with palpation of the posterior borders of the patella * Pain during squatting Classified as being within the strong subgroup of PFP (exemplified in the following sections). Exclusion Criteria * Individuals who are not part of a PFP group * Previous knee surgery and participants awaiting surgery for another lower limb joint problems * Ligamentous instability and/or internal pathology * History of patella subluxation or dislocation * Joint effusion when the midpatellar girth is 5% or more than the non-involved knee * True knee joint locking and/or giving way * Coexistent acute illness or chronic disease * Bursitis, patella or iliotibial tract tendinopathy, Osgood-Schlatter's disease, -Sinding-Larsen-Johansson Syndrome, muscle tears or symptomatic knee plicae * Pregnancy or breast feeding

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Conditions

The condition(s) this trial relates to.

patellofemoral pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Patellofemoral pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Sport of University of Porto

    Porto, 4200-450, Portugal

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