Could a bone drug ease pain in kids with rare inflammatory disease?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged ≥4 and \<17 years for whom: * Physician-confirmed diagnosis of CRMO according to Jansson's criteria, with compatible MRI findings. Having lesions on MRI within 12 weeks prior to inclusion and clinically active disease defined by at least one of 2 criteria: patient/parent VAS (pain) superior or equal to 30/100 and/or physician VAS superior or equal to 30/100 after failure of at least 4 weeks of NSAIDs at a stable dose * Written informed consent signed by the parents (the child may sign the consent if they wish, but their signature is not mandatory) * Having had a dental review within 3 months prior to inclusion, with completion of any necessary invasive dental work before the first dose of zoledronate. Exclusion Criteria: * History of malignancy or current tumour * History of seizure * Current infectious osteomyelitis * Contraindication to the study drug * Hypersensitivity to the active substance, to other bisphosphonates, or to any excipient (sodium hydroxide, hydrochloric acid for pH adjustment, water for injection) ; * Hypocalcemia ; * Severe renal impairment with creatinine clearance \< 35 ml/min ; * Prior treatment with bisphosphonates and/or biotherapy within 6 months prior to inclusion. * History of HIV, HBV, or HCV infection. * Congenital or acquired prolonged QT interval (\>0.44 seconds) on ECG. * Clinically significant vertebral deformities, including vertebral fracture and/or angular kyphosis with risk of spinal cord compression. * Suspected or confirmed tuberculosis. * History of renal or hepatic insufficiency. * Already enrolled in another interventional study. * Pregnant or breastfeeding participants * Not affiliated with the French social security system. * Patient or legal guardians with limited understanding of the French language * Serum 25-hydroxy vitamin D level \<30 ng/mL at screening. Participants may be re-screened after correction of vitamin D deficiency.