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Can your own blood ease nerve pain after disc surgery?
NCT ID NCT07770750
First seen Aug 18, 2026 · Last updated Aug 21, 2026 · Updated 3 times
Summary
This study tests whether injecting platelet-rich plasma (PRP) into the epidural space during endoscopic disc herniation surgery can reduce nerve pain in the leg. PRP is made from the patient's own blood and may help healing and reduce inflammation. The trial will enroll 50 adults with a single-level lumbar disc herniation who have not improved with conservative treatment. Participants will receive the PRP injection during surgery and complete questionnaires to assess neuropathic pain over six months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Platelet-rich plasma (PRP) injected into the epidural space during endoscopic disc removal
- What this could lead to
- If it works, this could point toward a way to reduce lingering nerve pain and improve recovery after disc herniation surgery.
- What could go wrong
- This is a small exploratory study, so results may not apply broadly. PRP is generally safe, but there is a small risk of infection or increased pain at the injection site.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients, male or female, aged ≥ 18 and ≤ 55 * Patients with a diagnosis of a single-level lumbar disc herniation confirmed by MRI * Patients in whom conservative treatment has failed for at least 6 weeks * Patients for whom monoportal endoscopic lumbar disc herniation excision is indicated * Patients with lower-limb radicular pain of an intensity ≥ 3/10 on the Numerical Pain Scale * Patients affiliated with or covered by a social security scheme * French-speaking patients who have signed an informed consent form Exclusion Criteria: * Patients with a history of lumbar spine surgery or epidural injection * Patients with progressive neurological deficits or cauda equina syndrome * Patients with coagulopathy or systemic hematological disorders * Patients with an active infection or autoimmune disease * Patients with multilevel disc herniation or concomitant cervical spine pathology * Patients with scoliosis \> 40°. * Patients already enrolled in another clinical study * Protected patients: adults under guardianship, curatorship, or other legal protection measures; patients deprived of liberty by judicial or administrative decision * Patients hospitalized without consent * Patients receiving psychiatric care * Patients unable to provide informed consent. * Pregnant or breastfeeding women, including parturient women
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hôpital Privé Jean Mermoz
Lyon, 69008, France
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