Papillon-Lefevre disease
MONDO:0009490Papillon-Lefevre syndrome (PLS) is a rare ectodermal dysplasia characterized by palmoplantar keratoderma associated with early-onset periodontitis.
Also known as: PLS, Papillon Lefèvre Syndrome, keratosis palmoplantar-periodontopathy syndrome, Keratoris palmoplantaris with periodontopathia, PALS, PAPILLON-Lefevre syndrome, Papillon-LEFèvre syndrome, Pls
26 clinical trials for this condition and its sub-types, 5 tagged with Papillon-Lefevre disease itself.
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Baking soda toothpaste may keep gum disease at bay
Disease control Recruiting nowThis study tests whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo for six months, whil…
Sponsor: University of Plymouth • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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AI vs dentist: which gives better oral hygiene tips for prediabetes?
Disease control Recruiting nowThis study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…
Sponsor: The University of Hong Kong • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Can advanced imaging reveal hidden swallowing muscle damage in IBM?
Diagnosis Recruiting nowResearchers at Johns Hopkins University are studying whether neuromuscular ultrasound and MRI can serve as reliable markers of swallowing muscle problems in people with inclusion body myositis (IBM). The study compares imaging and clinical findings in 30 participants, including p…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Sep 18, 2026 00:00 UTC
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New online tool could help you spot gum disease risk at home
Diagnosis Recruiting nowThis study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …
Sponsor: Universiti Sains Malaysia • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Gum surgery showdown: which stitch heals best?
Symptom relief Recruiting nowThis study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…
Sponsor: Aesculap AG • Aim: Symptom relief
Last updated Aug 15, 2026 00:00 UTC
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Could your gums be causing your neck pain? scientists investigate
Knowledge-focused Recruiting nowThis study examines a possible connection between gum disease and chronic neck pain. Researchers will compare neck pain intensity and daily disability among adults aged 30-55 with healthy gums, gingivitis, or periodontitis. Participants complete pain scales and questionnaires to …
Sponsor: Nigde Omer Halisdemir University • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC
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Massive data bank launched to unlock secrets of ALS and motor neuron diseases
Knowledge-focused Recruiting nowThis study is building a large database of health information from 5,000 people with ALS and other motor neuron diseases. Participants share details like symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then shared with resea…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC