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Could a simple paste replace drilling for Kids' tooth infections?

NCT ID NCT07542639

Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save the tooth. Researchers will follow 110 children for one year to see if the paste controls pain and infection as well as the standard method, potentially making treatment faster and more accessible in public health clinics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CTZ paste (chloramphenicol, tetracycline, zinc oxide, eugenol)
What this could lead to
If it works, this could offer a faster, simpler treatment option for infected baby teeth, making dental care more accessible in public health settings.
What could go wrong
This is a very early (Phase 1) trial with only 110 children at one center. The CTZ paste may not be as effective as the standard procedure, and long-term results are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 11 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pediatric patients presenting with: * Irreversible pulpitis in primary molars; * Pulp necrosis, with or without abscess, in primary molars. * Primary molars with sufficient remaining tooth structure to allow endodontic treatment. * Primary teeth in which the permanent successor tooth germ presents developmental stages compatible with Nolla stages 1 to 7, defined as: Stage 1: Presence of bony crypt with no evidence of calcification; Stage 2: Initial calcification, with appearance of radiopaque points in the crown region; Stage 3: Approximately one-third of crown formation; Stage 4: Approximately two-thirds of crown formation; Stage 5: Crown almost complete, without full calcification; Stage 6: Crown completely formed, without initiation of root formation; Stage 7: Initial root formation. * Clinical and radiographic conditions indicating feasibility of tooth maintenance through endodontic treatment, including: * Permanent successor in developmental stages prior to Nolla Stage 8; * Preservation of the bony crypt. Exclusion Criteria: * Pediatric patients presenting with: * Reversible pulpitis; * Indication for endodontic treatment in permanent teeth. * History of allergy or hypersensitivity to any components of the obturation materials (e.g., CTZ paste or zinc oxide-eugenol). * Clinical conditions that prevent adequate management in an outpatient setting. * Primary teeth in which the permanent successor: * Is in advanced developmental stages (Nolla Stage 8 or higher), and/or * Presents disruption of the bony crypt, contraindicating endodontic treatment. * Teeth presenting internal root resorption that compromises the feasibility of endodontic treatment.

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Conditions

The condition(s) this trial relates to.

dental pulp disorder dental pulp necrosis Fistula pulpitis suppurative periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental care for children Endodontics Health services accessibility Primary teeth Pulp disease, dental Pulp necrosis Pulp therapy in primary molars Pulpectomy Quality of life Treatment outcome

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.