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Can early radiation stop cancer bone breaks?

NCT ID NCT07540650

Disease control Sponsor: Institute of Oncology Ljubljana Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving radiation early to bone spots where cancer has spread can prevent complications like fractures or spinal cord pressure. About 90 adults with solid cancers that have spread to up to five bones will either get standard care or standard care plus radiation. The goal is to see if early radiation reduces bone-related events within one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
External beam radiotherapy
What this could lead to
If it works, this could reduce the risk of painful bone fractures and other serious bone complications in patients with cancer that has spread to the bones.
What could go wrong
This is a small, early-phase trial with only 90 participants, so results may not apply to everyone. Radiotherapy itself can cause side effects like fatigue or skin irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Histologically confirmed solid malignancy * Metastatic disease confirmed by imaging (CT, MRI, or PET-CT) * Presence of up to five high-risk bone metastases * High-risk bone metastases defined according to protocol criteria * Asymptomatic or minimally symptomatic bone metastases (not requiring opioid analgesics) * ECOG performance status 0-2 * Ability to provide written informed consent Exclusion Criteria: * Prior radiotherapy to the index bone metastases preventing safe treatment planning * Symptomatic bone metastases requiring immediate palliative radiotherapy * Evidence of spinal cord compression * Bone metastases causing significant pain requiring opioid analgesics * Oligometastatic disease suitable for radical treatment * Leptomeningeal disease * ECOG performance status ≥3 * Life expectancy less than 3 months * Any condition that, in the investigator's opinion, would interfere with study participation or assessment

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Conditions

The condition(s) this trial relates to.

metastatic carcinoma in the bone metastatic malignant neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone metastases Metastatic solid tumor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Institute of Oncology Ljubljana

    Ljubljana, 1000, Slovenia

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